Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"hematopoietic system"”.
-
Genomic architecture of the aging hematopoietic system
Hematopoiesis is a dynamic, yet tightly regulated process continuously replenishing populations of cells, including those with immune functions, that circulate in peripheral blood. Aging is associated with changes in hematopoiesis, resulting in altered composition and reduced function of immune …
-
Preclinical evaluation of a novel telomerase inhibitor in malignant cells of the hematopoietic system
… cytotoxic effect on malignant cells of the hematopoietic system which appears to be induce rapid sequestration of individual telomeres, the rate of proliferation plays also a crucial role in cells with longer telomeres.
-
Analysis of Minocycline as a Radioprotectant
… procedures and radiotherapy. Cells of the hematopoietic system, such as white blood cells (WBC), are especially sensitive to radiation and their decline can result in Acute Radiation Syndrome (ARS). Radiotherapy is often used for cancers of the central nervous system (CNS), but includes the …
-
The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency
… to make a rat-mouse chimera with an endothelium/hematopoietic system from a rat genetic background and the other tissues and organs from a mouse genetic background. The first series of experiments of this thesis work were designed to test the feasibility for the interspecific chimeras (mouse-rat …
-
Transposable elements and the regulatory logic of hematopoietic differentiation
… vitro for translational applications. The human hematopoietic system has long been a model system and an important source for adoptive cell therapies, yet, our understanding of the regulatory mechanisms that elicit commitment toward distinct hematopoietic lineages is continuously evolving. In …
-
Molecular Mechanisms in Hematopoietic Stem Cell Aging
… tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to ensure the existence of the HSC pool that is paramount to …
-
ZFP36L2 in Development and Adulthood: A Critical Regulator of Hematopoietic Stem Cell Homeostasis
… ZFP36L2 plays a pivotal role in maintaining hematopoietic stem cells (HSC) during development. ZFP36L2-deficient mice exhibit severely impaired definitive hematopoiesis and die approximately two weeks after birth due to severe anemia, thrombocytopenia, and internal hemorrhage. Recent …
-
Examining the effects of reactive oxygen species on functional potential of HSCS during aging
The role of ROS in the hematopoietic system has been a subject that has received little investigation due to the hypoxic environment inherent in the bone marrow niche. Furthermore, it is not known whether or not oxidative damage accumulations play a role in the functional decline of HSCs associated …
-
Feedback Regulation of Human Hematopoietic Stem Cell Fate
Hematopoietic stem cell (HSC) fate decisions at least in part determine cellular composition of the hematopoietic system. It is known that differentiated blood cells produce ligands that act on HSCs to influence HSC fate. However, fundamentals underlying the feedback regulation of HSC fate are …
-
MULTI-ORGAN FAILURE DRIVEN BY TELOMERE UNCAPPING
… outcomes in different cell types, however the systemic effects of acute TRF2 loss have remained poorly characterized. In this work, we adopted an inducible Trf2 knockout mouse model to investigate the consequences of telomere uncapping at the organismal level. Trf2 deletion was rapidly achieved …
-
The Role of Kit and Thrombopoietin in Regulation of Hematopoietic Stem Cells
The hematopoietic stem cell (HSC) is postulated to be the ultimate hematopoietic precursor providing production of mature blood cells, and is characterized by a life long capacity for self-renewal and multilineage differentiation. In a healthy human, the HSC produces 1,000,000,000,000 cells per …
-
Effects of acetyl salicyclic acid on Drosophila models of cancer-inflammation
… immune signaling causes overproliferation of the hematopoietic system leading to the production of inflammatory blood tumors. In mutant animals, hematopoietic cells divide uncontrollably and exhibit pre-mature differentiation giving rise to large sticky cells. Some mutant cells infiltrate and …
-
An in vivo evaluation of aneuploid hematopoietic stem cell fitness
… has yet to be elucidated, in part due to lack of systematic in vivo model systems. Furthermore, evaluation of aneuploidy-associated phenotypes in vivo has been difficult because autosomal trisomy is generally embryonic lethal in mice. Here, I have evaluated hematopoietic stem cells (HSCs) derived …
-
New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… dividing cells, and are extremely toxic to the hematopoietic system. The replication-dependent Fanconi anemia (FA) pathway defends against ICL toxicity in rapidly dividing cells. However, while it is critical for protecting the bone marrow, the FA pathway is ineffective in the less-proliferative …
-
Identification of Unique Hematopoietic Stem Cell Properties
Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and …
-
MICROGRAVITY NEGATIVELY AFFECTS DNA DAMAGE REPAIR AND THE ANTI-LEUKEMIC FUNCTION OF HUMAN NATURAL KILLER CELLS
… particles (SEPs) not present on Earth. The hematopoietic system constitutes one of the most radiosensitive tissues of the body and leukemias represent one of the most frequent radiogenic cancers with short latency periods. Therefore, leukemias may pose a distinct threat to astronauts during …
-
Genetic modeling of the Hippo pathway in hematopoietic stem cells
… of blood formation from a limited pool of hematopoietic stem cells (HSCs). These rare stem cells can both self-renew to maintain the HSC pool, and differentiate to continuously replenish lost blood cells. The mechanisms of HSC regulation are not fully known. The aim of this thesis was to …
-
Integrin α2 and Akt in early hematopoiesis
… is a tightly regulated process in which hematopoietic stem cells reside at the apex of the hierarchy, and produce all kinds of mature blood cells by differentiation to replenish the cell loss in homeostasis and acute injury. In past few decades, much effort has been made to purify …
-
Improving Leukocyte Recovery Through Physiologically Relevant Oxygen Expansion after Hematopoietic Stem Cell Transplantation
Rapid recovery of lymphocytes post hematopoietic stem cell transplantation (HCT) is correlated with positive patient outcome in treatments of hematologic disease. Few effective clinical therapies exist to enhance lymphocyte recovery, indicating a clear unmet need. Ex vivo expansion of umbilical …
-
Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia
The development and function of hematopoietic stem cells (HSCs) is regulated by numerous signaling pathways including Akt-mechanistic target of rapamycin complex1 (mTORC1) pathway. Dysregulation of this pathway results in impaired HSC function and contributes to the development of hematologic …
Page 1 of 2