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Showing 1 to 20 of 129 for “"hematopoietic stem cells"”.
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Regulation of Hematopoietic Stem Cells
This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate …
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
Large numbers of blood cells need to be continuously replaced in order to sustain the crucial functions of the immune system, oxygen transport and blood clotting. The large diversity of cell types required to maintain the integrity of the blood system are all produced from blood forming or …
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Hematopoietic Stem Cells and Progenitors in Murine Autoimmune Arthritis
<p>Although the physiological role of stem cells in generating and maintaining a functional biological system is widely appreciated, very little is known about the behavior of these cells in pathological conditions. If and how these primitive cells are affected by a disease process or may …
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Deciphering ARAP3 Functions in Hematopoiesis and Hematopoietic Stem Cells
… remains largely unstudied in hematopoiesis and hematopoietic stem cells (HSCs). In this thesis, we aim to elucidate the potential cell-autonomous and non-cell-autonomous roles of ARAP3 in hematopoiesis and HSCs using several conditional knockout (CKO) transgenic mouse models in addition to the …
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Genetic modeling of the Hippo pathway in hematopoietic stem cells
… of blood formation from a limited pool of hematopoietic stem cells (HSCs). These rare stem cells can both self-renew to maintain the HSC pool, and differentiate to continuously replenish lost blood cells. The mechanisms of HSC regulation are not fully known. The aim of this thesis was to …
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Self-renewal of human bone marrow-derived hematopoietic stem cells in vitro.
Self-renewal of human bone marrow-derived hematopoietic stem cells in vitro.
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The Role of Kit and Thrombopoietin in Regulation of Hematopoietic Stem Cells
The hematopoietic stem cell (HSC) is postulated to be the ultimate hematopoietic precursor providing production of mature blood cells, and is characterized by a life long capacity for self-renewal and multilineage differentiation. In a healthy human, the HSC produces 1,000,000,000,000 cells per …
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Transcriptional targeting of lentiviral vectors to the erythroblastic progeny of hematopoietic stem cells
… permanent gene transfer into self renewing, hematopoietic stem cells (HSC), and regulation of transgene expression in specific cell lineages. HIV-derived lentiviral vectors are very effective in transducing rare, non-dividing stem cell populations without altering their long-term repopulation …
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Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia
The development and function of hematopoietic stem cells (HSCs) is regulated by numerous signaling pathways including Akt-mechanistic target of rapamycin complex1 (mTORC1) pathway. Dysregulation of this pathway results in impaired HSC function and contributes to the development of hematologic …
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Development of a Human Immune System from Hematopoietic Stem Cells in a Human/Mouse Xenogeneic Model
T cells play a central role in the development of immune responses. Patients lacking T cells due to genetic defects such as DiGeorge or Nezelof's syndrome and individuals infected with the human immunodeficiency virus are highly susceptible to infections and cancers. The lack of adequate in vivo …
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Runx1 in Primitive Hematopoiesis and Characterization of Hematopoietic Stem Cells in a Mouse Chronic Inflammatory Arthritis Model
Hematopoietic cells are essential for growth and survival throughout adult life. Two different aspects of hematopoiesis are addressed in this dissertation. I. <underline>The regulation of primitive hematopoiesis by Runx1 and TGF-beta signaling.<underline> Primitive hematopoiesis, occurring …
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Developing a biomaterial model of the bone marrow perivascular niche for the study of hematopoietic stem cells
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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PTEN regulates the BMI1-mediated self-renewal of long-term hematopoietic stem cells in developmental and stress conditions
In the hematopoietic system, self-renewing long-term hematopoietic stem cells (LT-HSCs) maintain stem cell pools and differentiate into hematopoietic progeny. In addition to its critical role in the daily production of blood cells, LT-HSCs are able to resist the threats posed by various types of …
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Investigation of a suppression of asymmetric cell kinetics (SACK) approach for ex vivo expansion of human hematopoietic stem cells
Ex vivo expansion of hematopoietic stem cells (HSCs) is a long-standing challenge faced by both researchers and clinicians. To date, no robust, efficient method for the pure, ex vivo expansion of human HSCs has been demonstrated. Previous methods primarily induced the expansion of committed …
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The Rational Design and Use of Novel Small-Molecule Ice Recrystallization Inhibitors for the Cryopreservation of Hematopoietic Stem Cells and Red Blood Cells
… requiring transfusion and transplantation of cells has resulted in a need to preserve these cellular therapy products. Cryopreservation is the only currently used method for the long-term storage of cells. The most commonly used cryoprotectants are 10% dimethyl sulfoxide (DMSO) for …
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Advancing techniques for engineered tissue models of the bone marrow
Hematopoietic stem cells give rise to the blood and immune systems in organisms. These rare cells reside within the bone marrow and are the functional units of hematopoietic stem cell transplants, also known as bone marrow transplants. Methods to model the bone marrow and expand hematopoietic stem …
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Mobilisation, Isolation and Coculture of Haematopoietic Stem Cells
Since decades, hematopoietic stem cell transplantation (HSCT) has become a well established treatment modality for hematological malignancies and non-malignant disorders. Autologous and allogeneic hematopoietic stem cells (HSCs) mobilized into the peripheral blood (PB) have been used as a preferred …
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Single-cell analysis of hematopoietic cell fate on niche-mimetic platforms using Raman microspectroscopy
… achieve controlled and reproducible expansion of stem cells ex vivo. Hematopoietic stem cells (HSCs) are the best-studied class of tissue-restricted stem cells and their microenvironment in vivo has also been the subject of considerable research. Although a host of cellular, molecular and physical …
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