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Showing 1 to 20 of 114 for “"hematopoietic stem cell"”.
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Identification of Unique Hematopoietic Stem Cell Properties
Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and …
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Molecular Mechanisms in Hematopoietic Stem Cell Aging
The blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to …
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Feedback Regulation of Human Hematopoietic Stem Cell Fate
Hematopoietic stem cell (HSC) fate decisions at least in part determine cellular composition of the hematopoietic system. It is known that differentiated blood cells produce ligands that act on HSCs to influence HSC fate. However, fundamentals underlying the feedback regulation of HSC fate are …
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Targeting the hematopoietic stem cell to correct osteopetrosis
This thesis focuses on developing stem cell targeted gene therapy for the severe hereditary disorder Infantile Malignant Osteopetrosis (IMO) as well as increasing the understanding of how the genetic defect present in IMO affects the hematopoietic stem cells and hematopoiesis in general. IMO is a …
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Role of epigenetics in hematopoietic stem cell development
… treatments, such as molecules which stimulate hematopoietic stem cell (HSC) formation without the need for a donor. Therefore, a study was initiated to use human-induced pluripotent stem cell (hiPSC) technology to make a patient-derived, personalized HSC. Epigenetic regulators are divided into …
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A microfluidic platform for hematopoietic stem cell separation
… due to the complexity of the biological system can be overcome by introducing new engineering elements and performing systematic device optimization. In this work, a microfluidic immunoaffinity based silicon micropost device for hematopoietic stem cell enrichment is discussed, which …
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Refining Our Understanding of the Hematopoietic Stem Cell Niche
… major therapeutic goal of studying blood-forming hematopoietic stem cells (HSCs) is to understand the mechanisms by which HSCs are maintained in the bone marrow, so that they can be grown outside of the body and used in lieu of or in combination with bone marrow transplantation to treat …
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Saliva and oral mucositis after hematopoietic stem cell transplantation
Contains fulltext : 225513.pdf (Publisher’s version ) (Open Access)
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Activation of developmental signaling pathways in hematopoietic stem cell regeneration
<p>The homeostatic hematopoietic stem cell compartment is comprised of quiescent long term self renewing stem cells and cycling short term stem cells with finite renewal potential. To study the molecular mechanisms governing self renewal of hematopoietic cells we must force them to enter the cell …
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An in vivo evaluation of aneuploid hematopoietic stem cell fitness
Aneuploidy is an unbalanced cell state associated with developmental conditions such as Down syndrome (DS) as well as cancer, a disease of rapid proliferation. Studies of yeast, mouse and human cells harboring one extra chromosome have demonstrated that aneuploid cells show a number of common …
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Loss of Mismatch Repair in the Aging Human Hematopoietic Stem Cell
… result of failed DNA damage repair, in the adult stem cell (ASC) population. The hematopoietic stem/progenitor cell (HPC) is a well characterized example of ASCs. In second and third chapters I show evidence of age related accumulated genetic instability and epigenetic loss of the DNA mismatch …
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Role of Polycomb Group Protein Mel18 in Hematopoietic Stem Cell Maintenance
… gene silencers that have been implicated in stem cell maintenance and cancer development. Genetic and biochemical studies indicate that Polycomb group proteins exist in at least two protein complexes, Polycomb repressive complex 2 (PRC2) and Polycomb repressive complex 1 (PRC1). PRC2 complex …
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Multigradient hydrogels to decode extrinsic regulation of hematopoietic stem cell fate
… for the generation of all the blood and immune cells of the body. The cells responsible for this process are the hematopoietic stem cells (HSCs), primarily located within the bone marrow. They are housed in specific microenvironments (niches) that provide stochastically and temporally mutable …
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Factors That Influence Monocyte Differentiation and Hematopoietic Stem Cell Recruitment In Atherogenesis
… Studies have also shown that both the cell surface and intracellular expression pattern alterations occur in monocytes during these processes. Understanding how these early steps in atherogenesis occur is a prerequisite to the development of therapeutic agents that reduce inflammation …
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Single-cell approaches to assess hematopoietic stem cell response to matrix cues
Hematopoietic stem cells (HSC) are adult stem cells responsible for life-long hematopoiesis, the production of the full complement of blood and immune cells for hematological and immune systems. HSCs reside in the bone marrow within specialized microenvironments known as niches, comprised of …
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Improving Leukocyte Recovery Through Physiologically Relevant Oxygen Expansion after Hematopoietic Stem Cell Transplantation
Rapid recovery of lymphocytes post hematopoietic stem cell transplantation (HCT) is correlated with positive patient outcome in treatments of hematologic disease. Few effective clinical therapies exist to enhance lymphocyte recovery, indicating a clear unmet need. Ex vivo expansion of umbilical …
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Protein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem Cell Self-Renewal
<p>Hematopoietic stem cell (HSC) self-renewal, proliferation and differentiation are regulated by signaling through protein tyrosine kinases (PTK) such as c-kit, Flt-3 and Tie2. PTKs work in concert with receptor protein tyrosine phosphatases (PTPs) to maintain cellular equilibrium. The functions …
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ZFP36L2 in Development and Adulthood: A Critical Regulator of Hematopoietic Stem Cell Homeostasis
… ZFP36L2 plays a pivotal role in maintaining hematopoietic stem cells (HSC) during development. ZFP36L2-deficient mice exhibit severely impaired definitive hematopoiesis and die approximately two weeks after birth due to severe anemia, thrombocytopenia, and internal hemorrhage. Recent …
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Investigation of Bone Marrow Hematopoietic Stem Cell Migration during Inflammation in BALB/c Mice /
… anti-inflammatory effect of murine bone marrow hematopoietic stem cells and their migration in the BALB/c mouse contact hypersensitivity model in vivo. It was found that isolated hematopoietic cell populations had a significant anti-inflammatory effect and inhibited the edema. The studies showed …
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The diversity of participants in clinical trials involving allogeneic hematopoietic stem cell transplant recipients
… in clinical trials involving allogeneic stem cell transplant recipients matched the diversity of the actual allogeneic recipient population overall. It is important that clinical trials study new therapies in a population that represents characteristics of the overall treatment population …
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