Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"hematopoietic progenitors"”.
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The Role of Meis1 in Hematopoietic Development
… has been established, its function in hematopoietic development is still unclear. Previous lineage tracing demonstrated that <italic>Mesp1</italic> activity labeled endothelial cells of embryonic dorsal aorta, which recently was shown to give rise to definitive hematopoietic …
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Molecular Functions of MLL PHD3 Binding to Its Ligands Cyp33 and H3K4Me3
… H3K4Me3 resulted in decreased expansion of mouse hematopoietic progenitors in a methyl cellulose colony formation assay when compared to wt MLL-N. This indicates that the MLL PHD3 binding to H3K4Me3 contributes to histone H3K4 trimethylation, for the transcriptional activation of MLL target genes …
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Cold Shock Domain Proteins in Normal and Leukemic Hematopoiesis
… YBX1 and MSY4 are highly expressed in normal hematopoietic progenitors, and both are downregulated with terminal myeloid differentiation; both genes are highly expressed in virtually all cases of acute myeloid leukemia (AML). These two genes are functionally redundant as well: Msy4 has been …
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Dietary regulation of myelopoiesis and stromal cell isolation
… both diets reduced the presence of proliferating hematopoietic progenitors in the spleen, while neither diet influence hematopoietic progenitor proliferation in the bone marrow. In contrast to some reports, high salt did not influence myelopoiesis in normocholesteremic mice. Chapter 2 Stromal …
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Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System
… STAT5 phosphorylation and proliferation of hematopoietic progenitor cells. Furthermore, trFLT3 promoted de novo development of CNS-disseminating B-ALL from hematopoietic progenitors. Thus, a novel mutational mechanism involving ERV-mediated FLT3 activation can drive the development of B-ALL …
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A SEARCH FOR EPIGENETIC VULNERABILITIES OF AML CELLS PERFORMED BY A CDK INHIBITOR¿BASED CRISPR SCREENING
… proliferation and impaired differentiation of hematopoietic progenitors. Epigenetic dysregulation plays a central role in AML pathogenesis, and targeting chromatin-modifying enzymes has emerged as a promising therapeutic strategy. Among these, the histone demethylase LSD1/KDM1A has been …
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Humanized mice to test vaccination against influenza virus via dendritic cells.
… mice which, when engrafted with human CD34⁺ hematopoietic progenitors, develop all subsets of human dendritic cells(DCs) and B cells. T cells and their subsets were reconstituted by adoptive transfer. We found myeloid DCs, plasmacytoid DCs and monocytes in the bone marrow, spleen, and …
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… determined that lineage-negative (lin-) hematopoietic progenitors expressing E2A-PBX1 expression fail to repopulate the B-lymphoid lineage when transplanted into irradiated recipient mice. Furthermore, E2A-PBX1 expressing, lin- fetal liver progenitors (FLPs) fail to differentiate into …
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Runx1 in Primitive Hematopoiesis and Characterization of Hematopoietic Stem Cells in a Mouse Chronic Inflammatory Arthritis Model
Hematopoietic cells are essential for growth and survival throughout adult life. Two different aspects of hematopoiesis are addressed in this dissertation. I. <underline>The regulation of primitive hematopoiesis by Runx1 and TGF-beta signaling.<underline> Primitive hematopoiesis, occurring …
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Implications of a CALM-derived Nuclear Export Signal for CALM-AF10-mediated Leukemogenesis
… patients with aggressive and difficult-to-treat hematopoietic malignancies. <italic>CALM-AF10</italic>-driven leukemias are characterized by a perturbed epigenetic and transcriptional state. Specifically, the <italic>HOXA</italic> cluster genes are hypermethylated on Histone H3 lysine 79 (H3K79), …
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… tumors has shown that ZNF384 fusions arise in hematopoietic stem cells and that expression of the fusion, but not the concomitant genetic alterations, results in lineage aberrancy, however, the mechanistic role of ZNF384 rearrangements has not been formally studied. The goal of this project was …
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Pregnancy associated progenitor cells migrate, integrate and contribute to maternal hematopoietic compartments in the murine model
… in the lamina propria, PAPCs were mainly of a hematopoietic phenotype as judged by the expression of B- and T- cell markers such as CD19, IgA, CD4, and CD8 and the myeloid marker CD11b. Furthermore, intestinal PAPCs expressed the intestinal specific marker IgA which signifies that they could …
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Significance of Protein Interactions in Mediating AF9 Function
… HOXA9 and MEIS1, and enhanced proliferation of hematopoietic progenitors. MLL chimeras do not retain the histone methyltransferase activity of wild type MLL and it is unclear how they deregulate the expression of MLL target genes.</p><p>AF9 is one of the most common MLL fusion partners …
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Natural and Exogenous Genome Editing In Wiskott-Aldrich Syndrome Patient Cells
… the WAS protein (WASp), exclusively expressed in hematopoietic cells and required for proper platelet production and lymphoid cell function. Approximately 11% of patients with WAS exhibit a phenomenon called Somatic Revertant Mosaicism which is characterized by the presence of lymphocytes which …