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Showing 1 to 20 of 131 for “"hematopoiesis"”.
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Intercellular Feedback in Hematopoiesis
… disparate features of both normal and malignant hematopoiesis, relating internal parameters and microenvironmental variables to measurable cell fate outcomes. Through integrated in silico and experimental analyses we show blood stem and progenitor cell fate is regulated by cell-cell feedback, and …
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Nicotinic regulation of hematopoiesis
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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Trim24 In Normal & Malignant Hematopoiesis
… while having no observed effects on normal hematopoiesis. These results lay the groundwork for future investigations of the role of <em>TRIM24</em> in AML, which has the potential to aid development of novel therapeutic strategies.</p>
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The roll of integrins in hematopoiesis
Hematopoietic stem cells (HSCs) hold great promise for the treatment of disease. The rare frequency at which HSCs occur in the bone marrow under homeostatic conditions is a limiting factor in both their study and clinical use. ex vivo expansion of these cells is therefore a necessary step to …
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Integrin α2 and Akt in early hematopoiesis
Hematopoiesis is a tightly regulated process in which hematopoietic stem cells reside at the apex of the hierarchy, and produce all kinds of mature blood cells by differentiation to replenish the cell loss in homeostasis and acute injury. In past few decades, much effort has been made to purify …
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Hematopoiesis: Functional Insights by Cell Fate Conversion
Blood cell formation, or hematopoiesis, is maintained by rare hematopoietic stem cells (HSCs) residing in the bone marrow (BM). HSCs may self-renew (the process whereby HSCs replicate to produce new HSCs) to preserve their own numbers, as well as initiate a highly coordinated hierarchical …
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Investigating clonal hematopoiesis in rhesus macaque and human
Introduction <br>Clonal hematopoiesis (CH) describes the expansion of blood cell output from one HSPC linked to an acquired somatic mutation conferring a competitive advantage. While clonality is a feature of hematological malignancies, recent large deep sequencing studies have revealed that …
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Cold Shock Domain Proteins in Normal and Leukemic Hematopoiesis
… In mice deficient for either Ybx1 or Msy4, hematopoiesis is not altered. However, the loss of both proteins leads to a reduced ability for MLL-AF9 (a potent leukemia-initiating gene) expressing bone marrow cells to proliferate and serially replate in vitro, suggesting that Ybx1 and Msy4 have …
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The Characterization of Hematopoiesis in Murine Fetal Bone Marrow
… of cells that are indispensable for lifelong hematopoiesis and are often utilized in the clinic for the treatment of hematologic maladies via hematopoietic stem cell transplantation (HSCT). Over several decades, it has been discovered that HSCs arise in the dorsal aorta of the developing …
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Deciphering ARAP3 Functions in Hematopoiesis and Hematopoietic Stem Cells
… leukocytes, it remains largely unstudied in hematopoiesis and hematopoietic stem cells (HSCs). In this thesis, we aim to elucidate the potential cell-autonomous and non-cell-autonomous roles of ARAP3 in hematopoiesis and HSCs using several conditional knockout (CKO) transgenic mouse models in …
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Maternal β-Glucosylceramides Alter Neonate Hematopoiesis and Lung Microbiota
… we show that maternal β-Glucosylceramides alter hematopoiesis in the neonate by signaling through Mincle in hematopoietic precursors. This causes the expansion of IRF4+ dendritic cells, which are known to induce allergy. Furthermore, we show that the lung microbiota is altered in mouse pups born …
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The Consequences of Disrupting The Mdm2-P53 Balance In Hematopoiesis
… postnatal day 13 due to hematopoietic failure. Hematopoiesis progresses normally during embryogenesis until it moves to the bone marrow in late development. Increased oxidative stress in the bone marrow compartment postnatally is the impediment for normal hematopoiesis via activation of p53. p53 …
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Analyses of hematopoiesis and lineage commitment from ES and iPS cells
Die Kultivierung embryonaler Stammzellen (ES Zellen) und ihre Differenzierung zu verschiedenen Arten hämatopoietischer Zellen in vitro wurde optimiert und standardisiert, um eine zeitlich definierte, quantitativ auswertbare zelluläre Entwicklung zu verfolgen.Diese standardisierten in …
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The role of the leukemia-associated ETO homologue repressors in hematopoiesis
… to investigate the role of the ETO-homologues in hematopoiesis and leukemia. First, the finding of physical interactions between ETO homologues suggested a possible cooperation. Second, a ubiquitous expression was observed for MTGR1 and MTG16 in hematopoietic lineages. We also discovered that the …
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THE ROLE OF BMP SIGNALING AND ENDOGLIN IN REGULATION OF HEMATOPOIESIS
Hematopoiesis, the formation of blood cells, ultimately depends on a rare population of hematopoietic stem cells (HSCs), which can both self-renew to maintain the HSC pool, and differentiate into all mature blood lineages. HSC fate decisions are governed by a complex combination of numerous …
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The Role of Hspa9 in Mouse Hematopoiesis and IL-7 Receptor Signaling
… In order to understand the role of HSPA9 in hematopoiesis and disease development, we created an Hspa9 knockout mouse model. We characterized hematopoiesis of heterozygous mice (Hspa9+/-), which have a 50% reduction in Hspa9 expression, modeling the heterozygous loss of HSPA9 and 50% …
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Cell-Type Specific Requirement for Pyruvate Dehydrogenase in Hematopoiesis and Leukemia Development
Pages i-xii are misnumbered as pages ii-xiii, and page 142 is misnumbered as page 121.
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The Role of Cleavage and Polyadenylation Spcific Factor 6 (CPSF6) in Hematopoiesis
… types of blood diseases associated with abnormal hematopoiesis. CPSF6 is a subunit of the Cleavage Factor I mammalian (CFIm) complex, which regulates post-transcriptional alternative polyadenylation (APA) of pre-mRNAs. Previous research indicated that <em>Cpsf6</em> plays an essential role in …
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Insights into the clonal inventory of gene corrected human SCID-XI hematopoiesis
… to study the clonal composition of in vivo hematopoiesis after hematopoietic stem cell transplantation. <br>In the present study, a highly sensitive and specific LAM-PCR method was employed to characterize the in vivo hematopoiesis on DNA material from patient No. 4 of the French SCID-X1 …
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The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis
<p>The AF9 protein is one of the most common chromosomal translocation partners of the MLL gene in MLL leukemia. Wild-type AF9 is a member of the pTEFb transcription elongation complex, and interacts with gene regulatory proteins such as AF4/AF5q31, DOT1L, Pc3/CBX8 and BCoR. These interactions are …
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