Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"hematologic malignancy"”.
-
Assessing Patient Attitudes to ward Genetic Testing For Hereditary Hematologic Malignancy
… have been identified to predispose to hereditary hematologic malignancy (HHM). Although the diagnostic yield of germline analysis for leukemia is similar to solid tumors, referral for genetic evaluation in adults with leukemia is underperformed. Identifying HHM is important for prognostication, …
-
An Explanatory Model on Quality of Life in Patients with Hematologic Malignancy
본 연구는 혈액암 환자의 삶의 질을 설명하는 요인을 규명하고 요인들 간의 영향력을 확인하여 설명모형을 제안함으로서 혈액암 환자의 삶의 질을 예측하는 요인을 제시하고자 시도되었다. 본 연구의 가설적 모형 구축을 위하여 Wilson과 Cleary (1995)의 건강관련 삶의 질 모델과 혈액암 환자의 삶의 질에 대한 선행연구를 분석한 결과, 자기효능감, 진단 후 기간, 사회적 지지는 외생변수로 증상, 자가간호행위, 지각된 건강상태, 삶의 질은 내생변수로 선정하였다. 자료 수집은 경기도 소재 2개 병원과 한국 혈액암 협회에서 치료 과정에 …
-
Critical Illness in Patients with Hematologic Malignancies
Introduction: Patients with hematologic malignancy are at increased risk of developing life-threatening complications that can lead to admission to an Intensive Care Unit (ICU). Acute respiratory failure is the most frequent reason for ICU admission in these patients. Existing knowledge gaps in the …
-
The Regulation Of Myeloid Inflammatory Responses By Runx1: Roles In Normal And Malignant Hematopoiesis
… mutated in sporadic and inherited forms of hematologic malignancies, but the mechanism underlying it role in leukemogenesis remains poorly defined. In the first part of this work, we describe a novel role for RUNX1 in regulating TLR1/2 and TLR4 signaling and inflammatory cytokine production …
-
Ex Vivo Expanded Cord Blood Natural Killer Cells As A Novel Therapeutic For Multiple Myeloma
… myeloma (MM) is the second most common hematologic malignancy in adults and, to date, is incurable. Allogeneic natural killer (NK) cells are active in various hematologic malignancies and may have a role against MM. Umbilical cord blood is a potential source for allogeneic NK cells and …
-
Spectrum and Incidence of Primary and Therapy-Related Hematologic Malignancies In Individuals With Brca1 and Brca2 Pathogenic Variants
… myeloid neoplasms (t-MN) are rare and deadly hematologic malignancies that develop following exposure to cytotoxic therapies such as radiation, chemotherapy, and poly (adenosine diphosphate-ribose)-ADP polymerase (PARP) inhibitors. Preliminary evidence suggests that germline <em>BRCA1</em> and …
-
The Role of Pag1 In The Activated B-Cell Subtype of Diffuse Large B-Cell Lymphoma
… Lymphoma (DLBCL) is the most common aggressive hematologic malignancy in adults, but despite recent advances in treatment, many patients today still face poor outcomes. Of the two types of DLBCL, activated B-cell (ABC) and germinal center B-cell (GCB), patients diagnosed with the ABC subtype …
-
Donor lymphocyte infusion after allogeneic stem cell transplantation in children
… curative therapy for relapse or persistence of hematologic malignancy and bone marrow failure syndrome following allogeneic hematopoietic stem cell transplantation (allo HSCT). However, DLI is limited by the development of graft-versus-host disease (GVHD)and marrow aplasia, and the efficacy of …
-
A SEARCH FOR EPIGENETIC VULNERABILITIES OF AML CELLS PERFORMED BY A CDK INHIBITOR¿BASED CRISPR SCREENING
Acute myeloid leukemia is an aggressive hematologic malignancy characterized by uncontrolled proliferation and impaired differentiation of hematopoietic progenitors. Epigenetic dysregulation plays a central role in AML pathogenesis, and targeting chromatin-modifying enzymes has emerged as a …
-
Orthogonal Comparison of Nuclear and Mitochondrial Clonal Architectures in Hematologic Malignancies
<p>Acute myeloid leukemia (AML) is a hematologic malignancy characterized by accumulation of mutations that disrupt hematopoietic differentiation and promote clonal expansion. Understanding how these mutations arise and evolve is essential for improving diagnosis, prognosis, and treatment …
-
Heterogeneous Nuclear Ribonucleoprotein K (Hnrnp K) Overexpression and Its Interaction With Runx1 Rna In Acute Myeloid Leukemia
… myeloid leukemia (AML) is an often devastating hematologic malignancy with 5-year overall survival lingering near 20%. Acquiring a deeper understanding of molecular underpinnings of leukemogenesis will provide a basis for developing more effective therapeutic strategies for patients with …
-
Symptom Burden and Health-Related Quality of Life in Adults with Multiple Myeloma
… of the plasma cells, is the second most common hematologic malignancy in the United States with an estimated 34,920 new cases and 12,410 deaths in 2021. Though still considered incurable, treatment advances in the last 20 years have dramatically extended survival for many with MM. Overall median …