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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"hemagglutinin"”.
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Influenza hemagglutinin expression in Nicotiana tabacum and Nicotiana benthamiana.
Influenza infects millions of people each year. Hemagglutinin (HA) is the major surface protein of the influenza virus and the best target as a vaccine candidate. Transgenic plants have significant potential for proper expression of HA to serve as an influenza vaccine. An HA3 DNA construct for …
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Glycan receptor binding determinants of Influenza A virus hemagglutinin
… of mutations in the viral coat glycoprotein, hemagglutinin (HA), which changes its binding specificity towards glycan receptors in the human upper respiratory epithelia (referred to as human receptors). In this thesis, determinants that mediate changes in HA-glycan receptor binding specificity …
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Engineering and targeting glycan receptor binding of influenza A virus hemagglutinin
… is the binding of the viral surface glycoprotein hemagglutinin (HA) to the sialylated glycan receptors terminated by N-acetyineuraminic acid (Neu5Ac) expressed on the host cell surface. Glycans terminating in Neu5Ac that is a2-6 and a2-3 linked to the penultimate galactose serve as receptors for …
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Variation in influenza virus neuraminidase activity influences the evolutionary trajectory of hemagglutinin
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Intracellular Trafficking of Influenza Hemagglutinin and Members of the Low Density Lipoprotein Receptor Family
… biosynthetic and endocytic pathways. Influenza hemagglutinin is sorted to the apical membrane in polarized epithelial cells by a mechanism mediated by an association with lipid microdomains known as lipid rafts. Lipid rafts and their associated proteins are operationally defined by their …
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Cloning, sequencing and physicochemical characterization of a hemagglutinin from Escherichia coli 09:H10:K99
… cloned from Escherichia coli 09:H10:K99. This hemagglutinin was determined to be different from the two mannose-resistant hemagglutinins that this strain was known to possess, F41 and K99, and was named Heat Resistant Agglutinin 1 (HRA1) on the basis of one of its physical properties. The HRA1 …
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Anatomy of the coiled coil and its role in the conformational change of influenza hemagglutinin
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Determinants in the pandemic H3N2 influenza A virus hemagglutinin that affect receptor binding and transmission in the pig
… met 2 (R2-HK) of 5 (R5-HK) mutaties in het hemagglutinine.
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Glycan Shielding of the Influenza Virus Hemagglutinin Elicits Evasion of the Adaptive Immune Response and T-Cell-Driven Pathology
… glycosylation sites on the globular head of the hemagglutinin protein. In contrast, recent non-pandemic isolates have acquired such sites. Here we constructed isogenic viruses containing differing numbers of additional N-linked glycosylation sites to assess the impact on the host immune response. …
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On the role of conformational flexibility in viral fusion mechanisms - fusion by disorder
… time evolution. We first analyze Influenza A Hemagglutinin, where we show that Hemagglutinin can transition by two dominant pathways. Both pathways are characterized by an early order-disorder transition in a characteristic hairpin region and breaking of the threefold symmetry present in the …
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The Role of Bps Polysaccharide in Bordetella Resistance to Host Innate Defenses
… mediate binding to the host such as filamentous hemagglutinin and pertactin. A crucial component of successful colonization is evasion of host defenses. Biofilms have been proposed to promote bacterial persistence by suppressing the effectiveness of host responses. A hallmark of mature biofilms …
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Decoding structure-function relationships of glycans
… glycans and GBPs in two areas: i) the role of hemagglutinin-glycan receptor specificity in human adaptation and pathogenesis of influenza and ii) the function of glycan regulation of cell-microenvironment interaction in cancer progression. Section 1: Influenza poses a significant public health …
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Chaperoning viral protein evolution
… tolerance of influenza nucleoprotein and hemagglutinin in modulated cytosolic and endoplasmic reticulum (ER) folding environments, respectively. The nucleoprotein work provides the first experimental evidence that host chaperones can enhance the accessibility of biophysically deleterious, …
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Can Plant Plastid Produce a Candidate Influenza Vaccine?
… a large scale. The influenza virus coat protein hemagglutinin (HA) is a major surface antigen and has emerged as a good candidate antigen for subunit vaccine development. Previous attempts to express HA from the A/Sichuan/2/87 H3N2 influenza subtype in plastids achieved HA gene transcription but …
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The Effect Of Maternal Antibodies On Anti-Viral Immunity In Infant Mice
… nanoparticles (mRNA-LNP) encoding influenza hemagglutinin, overcomes maternal antibody inhibition by prolonged establishment of germinal centers. mRNA-LNP vaccination offers a promising means of eliciting protective immune responses in infants in the presence of maternal antibodies. These …
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Atomic-level characterization of protein-lipid interactions using molecular dynamics simulations
… the metabolism of a wide range of molecules, the hemagglutinin fusion peptide (HAfp), a small peptide that mediates the fusion process of the influenza virus to a host cell, and the T-cell immunoglobulin and mucin domain (Tim) proteins, involved in the mechanism of lipid recognition by T-cells.
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Glycans in host-pathogen interactions : an integrated biochemical investigation
… between sialylated glycan-receptors and viral hemagglutinin (HA). The study puts forth the concept that the topology or shape (going beyond the chemical c2-3 versus a2-6 sialic acid linkage) adopted by the sialylated glycans is the critical determinant for efficient human adaptation of these …
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