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Showing 1 to 3 of 3 for “"helicase mechanisms"”.
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Single molecule studies of helicase mechanisms
Bloom helicase (BLM) is a member of the RecQ helicase family, a group of 3’ to 5’ helicases which are homologs of the RecQ protein found in E. coli. Besides the canonical helicase function of unwinding duplex DNA, the RecQ family of helicases is known to preferentially bind to non-canonical DNA …
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Exploration of helicase mechanisms at single molecule level: answering decades old questions and bioengineering super proteins
… often averaged out and lost in ensemble assays. Helicases form a ubiquitous class of enzymes that function in many aspects of nucleic acid metabolism which is central to life. We used single molecule Förster resonance energy transfer (FRET) and optical tweezers force spectroscopy to study …
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Exploration of helicase mechanisms at single molecule level: answering decades old questions and bioengineering super proteins
… often averaged out and lost in ensemble assays. Helicases form a ubiquitous class of enzymes that function in many aspects of nucleic acid metabolism which is central to life. We used single molecule Förster resonance energy transfer (FRET) and optical tweezers force spectroscopy to study …