Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"helicase domain"”.
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Context Dependent Regulation of Dicer Function During Oocyte-to-Embryo Transition
… including the revelation that the Dicer helicase domain has an exclusive regulatory effect on developmental endo-siRNAs. Despite this revelation, the mechanisms regulating Dicer helicase domain activity and subsequent endo-siRNA biogenesis are enigmatic due to the responsibility of …
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SWI/SNF-NUCLEOSOME INTERACTIONS AND DISASSEMBLY OF NUCLEOSOMES: NOVEL METHODOLOGIES FOR MAPPING PROTEIN-PROTEIN AND PROTEIN-DNA INTERACTION
… octamer as a probe, was applied to identify the domains and motifs of SWI/SNF subunits that interact with DNA and nucleosome. It was found that motifs in the N-terminal lobe of ATPase/helicase domain of Sw2/Snf2 are in close contact with both DNA and histone octamer. Crosslinking and peptide …
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MIR-122 and DDX6 facilitate hepatitis C virus replication via independent mechanisms
… HCV replication such as miR-122 and DEAD-box RNA helicase, DDX6 may facilitate development of novel therapies. miR-122 is a liver-specific microRNA that is required for efficient replication of HCV in hepatocytes. Mutational analyses of the genotype 1a/2a chimeric HCV (HJ3-5) genomes indicated …
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Hepatitis C Virus NS3/4A Protease and the Intracellular Antiviral Response: Mapping Complex Virus-Host Interactions
… serine protease and a carboxy-terminal RNA helicase. A structure-function analysis of NS3/4A truncation and deletion mutations was conducted. Mutants lacking the helicase domain retained the ability to control RIG-I signaling, but this regulation was abrogated by truncation of the protease …