Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"helical structure"”.
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Structure and conformations of heteropolysaccharides
… by Xray diffraction techniques. A four-fold helical structure having a fibre repeat of 3.39 nm is the more readily obtained form. Initial computer model building studies showed that a double helical structure was one interpretation of the data. Subsequent calculations by colleagues have shovn …
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Solvophobically-Driven Folding of Non-Biological Oligomers and the Solid Phase Synthesis of Phenylacetylene Oligomers
… can serve as a repeating motif to produce helical structures in solution which posses a tubular cavity. Calculations with modest size oligomers show stable helical conformations with as few as 8 monomer units. Oligomers with triglyme monomethyl ether benzoate functionalized monomers (R = …
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Host-defence peptides from frog skin secretions: identification and bioactivity evaluation and optimisation
… analogues were designed based on the secondary structure. Results revealed that the helical structure is critical for antimicrobial activity and haemolytic activity of peptides. The kink structure is important in antimicrobial activity against Gram-negative bacteria. A novel AMP, brevinin-1W …
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Investigation into the membrane interactive properties of the escherichia coli low molecular weight penicillin-binding proteins
… interactive protein molecules. Whether such helical structure features in the membrane associations of PBP4 or indeed if this protein is membrane bound or soluble, are, as yet, open questions. The focus of this research has been to investigate the lipid and membrane interactions of PBP4, PBP5 …
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Structural basis of membrane targeting and regulation of the innate immunity adaptor TIRAP by its phosphoinositide-binding motif
… approaches. I show that TIRAP PBM adopts helical structural in dodecylphosphocholine (DPC) micelles and other membrane mimics. NMR studies reveal that TIRAP PBM binds PIPs following a fast exchange regime with a moderate affinity through two conserved basic termini. Mutation of these two …
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Molecular genetics and functions of Kaposi's sarcoma-associated herpesvirus glycoproteins in viral entry and virus-induced cell fusion
… that fully or partially truncated a predicted a-helical structure of the gB carboxyl terminus known to be involved in virus-induced cell fusion from studies with the herpes simplex virus type 1 (HSV-1) gB. Initial experiments suggested that disruption of the predicted a-helical structure gBtH2 …
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Design and Synthesis of Hyaluronan:RHAMM Interaction Inhibitors
… domains is predicted to lose their natural α-helical structure. The goal of this project is to explore the effects cyclizing each binding domain has on helicity and its biological effect. Eighteen peptides were synthesized and cyclized using lactam bridges. The peptides were analyzed by …
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Folding-Promoted Reactivity and Tunable Structure of Pyridine-Containing M-Phenylene Ethynylene Helical Cavitands
… through noncovalent interactions in the folded helical structure. When the pyridine ring bears a N,N-dimethylamino substituent, the folded structure of the oligomer is shown to promote methylation of the pyridine nitrogen. The lowered energy barrier for this reaction results from binding of the …
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Folding-Driven, Nucleation -Elongation Polymerization of Phenylene Ethynylene Imines
As a result of the helical structure of the polymeric product, the polymerization of oligo(m-phenylene ethynylene) imines in solution should inherently show nucleation-elongation in chain growth. The evidence for this behavior was obtained from polymerizations conducted under conditions of …
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Model membrane interactions with ions and peptides at the air/water interface
… viral fusion processes. Alteration of peptide structure could be a cause of many diseases. Biological membranes are complex systems, therefore simplified models may be introduced in order to understand processes occurring in nature. The lipid monolayers at the air/water interface are suitable …
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\(Pyrococcus\) \( furiosus\) amylase as a Candidate Sterilisation Time-Temperature Integrator
… by first order kinetics from a \(\alpha\)-helical structure, through \(\alpha\)-sheet structure to aggregation of the enzyme.
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Assessing bioactivity of a peptide from the skin secretion of the central American red-eyed leaf Frog, Agalychnis callidryas
… antimicrobial peptides with positive charge, α-helical structure and strong amphiphilicity. In this study, QUB-2428, a peptide related to the plasticins from the dermaseptin superfamily, was isolated from the skin secretion of the Central American Red-eyed Leaf Frog, Agalychnis callidryas. A …
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Electromagnetic-thermal Characteristics of Conductor on Round Core (CORC) Cables
… consisting of a cylindrical former and multiple helically bent HTS-CCs, exhibit more significant current-carrying capacity while reducing alternating current (AC) losses. They are promising candidates for low-loss power transmission and low-inductance high-field magnets. This thesis carries out …
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Exploring induced secondary structure and unmethylated DNA binding domains of methyl CpG binding protein 2 (MeCP2)
… of Methyl CpG binding protein 2 (MeCP2) structure and function has changed and expanded considerably over the last two decades. Mutations along the entirety of the human MeCP2 gene product lead to a disease state - Rett syndrome. The clinical connection of this protein has continued to …
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Structural and Biochemical Investigation of the Pan2-Pan3 Deadenylase Complex
… deadenylases recognise the intrinsic stacked, helical structure of single-stranded poly(A) RNA. Recognition of this conformation in different biological contexts, enabled by the unique physicochemical properties of adenine, suggests a possible reason for poly(A) conservation. Chapter 3 examines …
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The Influence of the Cellular Environment on Z-DNA Formation
… Distinct from the familiar right-handed BDNA helical conformation, Z-DNA is a left-handed double helical structure with its phosphodiester backbone arranged in a zig-zag pattern that is unique to Z-DNA. Moreover, due to the correlation between Z-DNA formation potential and regions of active …
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The Influence of Osmolytes on Nucleic Acid Helical Conformations
… cosolutes were observed on the transition of helical conformation from B-DNA to Z-DNA. Distinct from the familiar, right-handed B-DNA, Z-DNA is a left-handed double helical structure with its phosphodiester backbone arranged in a pronounced zig-zag pattern. This pattern, unique to Z-DNA is …
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Investigating the orientational order in smectic liquid crystals.
… appears between the SmC∗ #11; phase having a helical structure and the SmC∗d4 phase with four-layer periodicity. The SmC∗ d6 phase shows a distorted clock structure. Three theoretical models have predicted the existence of a six-layer phase. However, our experimental findings are not …
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Identification and evaluation of bioactive peptides from amphibian skin and rational design of new analogues
… Temporin-LTd is a linear cationic short alpha-helical peptide with strong antimicrobial activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. In chapter 5, three analogues of DRP-AC4 were designed to employ the influence of cationicity, hydrophobicity and …
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The Engineering and Development of pH-Responsive Biopolymers for Drug Delivery Applications
… describes experimental studies to understand the structure of biocompatible pH responsive polymers and their interaction with the biological system in order to design more effective entities for biomedical applications. A systemic approach was used to study the structure and biological interaction …
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