Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"helical peptides"”.
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Characterization of short template-nucleated helical peptides
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Investigating K-Ras inhibition by α-helical peptides
… into alternative methods to target K-Ras. α-helical peptides present an effective method to inhibit protein-protein interactions such as those between K-Ras and its effectors. So far, K-Ras-targeting α-helical peptides have been resticted to SOS1 mimetics. This work aimed to investigate …
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Adsorption and conformation change of short helical peptides on silica and aluminosilicate surfaces
… protein adsorption, the interactions between (-helical peptides and a carefully selected set of model surfaces were studied. The peptide sequences contained three blocks of two to five residues each, with the side chains of the N-terminal and C-terminal blocks having negative and positive …
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Anticancer a-helical peptides and their structure / function relationships underpinning their interactions with tumour cell membranes
… agents has led to the discovery of toxic peptides with cancer cell specificity. Extensive research is therefore required to determine how these anticancer peptides (ACPs) function and how their structural characteristics relate to both specificity and efficacy. An ACP database comprising …
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Synthesis and conformation of peptides : I. stability of short templated alpha-helical peptides ; II. new templates for intramolecular acyl transfer
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.
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DE NOVO DESIGN OF ANTIMICROBIAL PEPTIDES FOR APPLICATION AS ANTI-INFECTIVE AGENTS
Antimicrobial peptides (AMPs) have gathered considerable interest as a new source of antibiotics to tackle the escalating threat of antimicrobial resistance. Adopting a de novo approach enables the rational design of short synthetic AMPs, whilst mitigating concerns of resistance development to …
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Identification and bioactivity evaluation of a novel peptide from the skin secretion of Pelophylax kl. esculentus
… in their skin or skin secretions. Among these, peptides are found with broad-spectrum antibacterial and antifungal activities, as well as anticancer properties. It is generally assumed that these cationic, amphipathic and α-helical peptides constitute a part of the innate immune system that …
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Expanding the Spiroligomers Toolbox as Protein-Protein Interaction Inhibitors
… functionalized spiroligomers that mimic the helical domain of p53 was undertaken before each molecule was tested for binding to HDM2, a natural binding partner of p53. A library of molecules was synthesized on solid support that altered the stereochemistry along the spiroligomer as well as …
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Experimental characterization of polyalanine helices in short and long contexts
… helicity in order to determine the intrinsic helical propensity of an alanine residue, free from the hydrophobic packing within proteins. Constructed cross checks between these methods add rigor to propensity assignments and present the opportunity to resolve controversies regarding helical …
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Copper-catalyzed arylation of 1,2-amino alcohols. Synthesis of N-terminal, peptide helix initiators, and characterization of highly helical, capped polyalanine peptides
… were combined to synthesize a series of highly helical, water-soluble polyalanine peptides permitting straightforward context-free investigation of this most common helix- forming [alpha]-amino acid. Three types of peptides incorporating this helical polyalanine region were made, each for a …
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Experimental and theoretical investigation of the electronic structures of ferrocene-peptide conjugates
… electronic structures of a number of modified helical peptides, specifically ferrocene-(proline)x-benzyl ester (referred to as Fc-Proₓ-OBz), is presented. Soft X-ray absorption (XAS) and emission (XES) spectroscopy using synchrotron radiation are used to probe the unoccupied and occupied …
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Design and synthesis of molecular tools for the ubiquitin proteasome system
… by the α-helix 9 of E2-25K. Creating a short helical peptide analogous to α-9 of E2-25K with the technique of peptide stapling could potentially block the action of Ubb+1 and provide a tool to investigate the role of the UPS in AD.Following synthesis of the requisite alkenyl amino acids for …
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Dose-Dependent Effects of Salmon Calcitonin on Bone Turnover in Ovariectomized Rats.
… were noted between groups for levels of urinary helical peptides or serum pyridinoline [ELISA], indicators of bone resorption. Urinary calcium excretion [capillary ion electrophoresis] was significantly higher in subjects receiving 50 IU/kg of calcitonin than other ovariectomized subjects …
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Model Membranes Study the Lipid-Reactivity of HIV-1 Antibodies and Vaccine Antigen
… SLB formation technique that uses amphipathic, α-helical peptides as a catalyst to generate complex SLBs that have a high cholesterol content and contain multiple lipid types. For all SLB surfaces we used atomic force microscopy (AFM) to visualize membrane domains, antigen presentation, and …
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Materials and biological approach to gene delivery in human embryonic stem cells
… contained a membrane-disruptive, cationic, helical polypeptide block (PVBLG-8) for complexing with DNA and a hydrophilic PEG block to improve the biocompatibility of the gene delivery vehicle. PEG-b-PVBLG-8 diblock polymers with a high degree of polymerization have a greater transfection …
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Structural investigation of lanthipeptides involved in substrate controlled pathways and methods for leader peptide removal
… synthesized and post-translationally modified peptides are a family of natural products with diverse activities, with lanthipeptides as one of the most prominent classes. The diverse ring topology of lanthipeptides is formed by four classes of enzymes with substrate tolerance that holds …
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Materials and biological approach to gene delivery in human embryonic stem cells
… contained a membrane-disruptive, cationic, helical polypeptide block (PVBLG-8) for complexing with DNA and a hydrophilic PEG block to improve the biocompatibility of the gene delivery vehicle. PEG-b-PVBLG-8 diblock polymers with a high degree of polymerization have a greater transfection …