Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 136 for “"hedgehog"”.
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Studies of Smoothened in Hedgehog Signaling Pathway
The Hedgehog (Hh) family of morphogens controls cell growth and patterning in both vertebrates and invertebrates. Malfunction of Hh signaling has been implicated in numerous human disorders. As the Hh signal transducer, the seven-transmembrane protein Smoothened (Smo) is highly regulated. It is …
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Targeting c-met in sonic hedgehog medulloblastomas
… four molecular subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 and Group 4. Although the 70-75% of MB patients survive the disease, the current therapeutic regimen, which comprises surgical resection, chemotherapy and cranial irradiation, is worryingly associated with severe side effects …
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HEDGEHOG SIGNAL TRANSDUCTION IN EFFECTOR IMMUNE CELLS
Hedgehog (Hh) signalling is a classical morphogen pathway that regulates key processes in embryonic development, adult tissue homeostasis, and tumorigenesis. Recently, the Hh pathway has also been shown to be critical for CD8+ and CD4+ effector functions, acting in a cell-autonomous manner and …
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Hedgehog signalling in CD8+ T cell memory
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The Role of Sonic Hedgehog in the Hypothalamus
ABSTRACT THE REQUIREMENT OF SONIC HEDGEHOG IN THE HYPOTHALAMUS Solsire E. Zevallos Douglas J. Epstein Sonic hedgehog (Shh) is a morphogen secreted during early development that is required for the formation of the ventral neural tube, including the ventral forebrain. The prechordal source of Shh …
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Astrocytic Sonic Hedgehog signalling in development and disease
Sonic hedgehog (Shh) signalling is a critical pathway in embryonic development, with known roles in cell differentiation, tissue patterning, and the establishment of body axes (Rowitch et al., 1999; Echelard et al., 1993; Ericson et al., 1997; Jessel and Lumsden, 1997). Beyond these canonical …
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Sonic hedgehog signaling pathway in normal and adenomatous pituitary
… first time the expression and the role of Sonic hedgehog signaling pathway in adult pituitary and in pituitary tumors. Shh is a signaling protein, important in regulating patterning and proliferation in the embryo and the adult. It has a crucial role in pituitary development and Shh deficient …
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The Role of Sonic Hedgehog in Outflow Tract Development
… pathways. One of these pathways is the Sonic hedgehog pathway. This thesis tests the hypothesis that Sonic hedgehog induces secondary heart field proliferation, which is necessary for normal outflow tract development. To address this hypothesis, I took advantage of small chemical antagonists …
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The Misexpression of Sonic Hedgehog Leads to Digit Duplication
… activity (ZPA). The secreted molecule, sonic hedgehog (Shh) is produced by the cells of the ZPA and has been shown to play an important role in this process of pattern formation. Grafting the cells of the ZPA onto developing host tissue induces mirrorimage limb duplication. In addition to …
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Hedgehog Signaling Modulates Cholesterol Homeostasis in Chondrocytes and in Osteoarthritis
… cartilage, and subchondral bone changes. Hedgehog (Hh) signaling is known to be activated in human and murine OA. Since Hh signaling regulates Gli-mediated gene expression, we identified Hh target genes that are expressed in chondrocytes. Microarray analyses were performed to detect …
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Hedgehog Signaling Plays a Conserved Role in Inhibiting Fat Formation
The involvement of hedgehog (Hh) signaling in cell determination and differentiation in a wide variety of tissues in both invertebrates and vertebrate has been well established. However, relative little is known about its function in formation of adipose tissues. To address this question, …
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Single-cell Transcriptome Profiling Reveals Hedgehog Critically Regulates Hepatocyte Resiliency
… In the work presented here I focused on Hedgehog, a lipid-sensing developmental morphogenic pathway, and uncovered how its regulation mediates multiple hepatocyte functions in adult livers, including metabolic homeostasis and the regenerative response to liver injury. These findings not …
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Dissecting the Role of Hedgehog Pathway in Murine Gonadal Development
"The main hypothesis of this dissertation was that gonadal Hh signaling, through the putative mammalian GLI proteins, is alone essential and sufficient to induce FLC differentiation. My objective was to address three main questions concerning the role of Hh signaling in gonadal development. In …
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The role of Hedgehog signalling in T cell effector function
… of challenges such as infection and cancer. The Hedgehog (Hh) signalling pathway has long been known to play a critical role in embryonic development and adult tissue maintenance. Recently, Hh signalling has been shown to be important for CD8+ T cell function downstream of T cell receptor (TCR) …
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Ο ρόλος του σηματοδοτικού μονοπατιού Sonic Hedgehog στον καρκίνο του πνεύμονα
… έγινε μελέτη του σηματοδοτικού μονοπατιού Sonic Hedgehog σε 96 περιστατικά καρκίνου πνεύμονα με τη μέθοδο της ανοσοϊστοχημείας. Επίσης μελετήσαμε την πιθανή συμμετοχή του μεταγραφικού παράγοντα FoxM1 στο καρκίνωμα του πνεύμονα και την πιθανή συσχέτισή του με το μονπάτι του Hedgehog. Έγινε μελέτη …
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Investigating the Role of Dispatched in Hedgehog Ligand Transport and Delivery
<p>During the development of all metazoans, the Hedgehog (Hh) signaling pathway provides instructional cues influencing a variety of cellular processes. The pathway ligand, Hh, is dually lipidated by cholesterol and palmitate, which effectively anchors the molecule to the lipid bilayer of the …
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Role of Sonic Hedgehog in Development of the Central Nervous System
Sonic hedgehog (Shh) functions as a morphogen to induce early dorso-ventral patterning of the central nervous system (CNS) and specifies cell fates of spinal motor neurons. Shh has also been known to promote cell cycle progression of embryonic stem cells as well as adult neural stem/progenitor …
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Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
Sonic hedgehog (Shh) is a member of the hedgehog family of signalling molecules and secreted from two signalling centers, the notochord and the floor plate, where it functions as a morphogen to induce early dorso-ventral patterning of the cenral nervous system (CNS). More recently, multiple actions …
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Hedgehog signaling: a potential therapeutic target for non-small cell lung cancer
… (A549-M cells) led to the up-regulation of sonic hedgehog (Shh) both at the mRNA and protein levels causing activation of hedgehog signaling. These results were also reproduced in another NSCLC cell line (H2030), and these results were further associated with the induction of EMT phenotype. …
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