Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"heavy-chain antibody"”.
-
From detection of proteasomal degradation to targeted control of protein depletion
… antigen-binding fragment from the Camelidae sp. heavy-chain antibody engineered to mediate degradation through the proteasome. Guided by predictive modeling, I show that customizing the NanoDeg rate of synthesis, rate of degradation, or mode of degradation allows to achieve quantitatively …
-
Developing nanobodies to stabilise the tumour suppressor protein p16INK4a
… leading to unfolding or aggregation. Heavy-chain antibodies are a unique form of antibody devoid of light chains found in the serum of the Camelid family (camels and llamas). Despite the absence of light chains, heavy-chain antibodies have evolved to complement traditional antibodies …