Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"heart valve"”.
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NOVEL NANOFIBER-BASED GRAFT FOR HEART VALVE REPLACEMENT
Creating a functional heart valve graft that lasts a lifetime is one of the main targets of cardiovascular tissue engineering. While processed conventional collagen-based heart valves have been used for many years, they eventually fail because of inadequate cell infiltration and insufficient …
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The Green Lane Valve: a Novel Decellularised Heart Valve
… routine surgical use. Thus, tissue-engineered heart valves have been explored as alternative conduits. Unfortunately, early models have proceeded to clinical use with catastrophic outcomes. The clinical performance of contemporary decellularised heart valves remains unknown. A novel, …
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A novel polymeric prosthetic heart valve: design, manufacture, and testing
… a flexible leaflet polymeric prosthetic aortic heart valve was designed, manufactured, and tested. The prosthesis was designed with the aim of overcoming the need for anticoagulant therapy, which is required for current mechanical prostheses; while also having lifelong durability, which current …
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Material selection and manufacture for a polymer heart valve application
… selection, manufacture and testing of a polymer heart valve made entirely from block copolymer. Selection based on Ashby diagrams pointed towards styrene-based and polyurethane-based block copolymers as candidate materials for study. Styrene-based block copolymers had been well studied in their …
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Non-linear finite element analyses of the aortic heart valve
Finite element models of the aortic heart valve have been successfully used in the past to gain insight into the mechanics of the valve and to aid in understanding of valve failure. Moreover such models are indispensable tools for further developments in heart valve prosthetic design. In previous …
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The tricuspid artificial heart valve : an analysis of opening characteristics
Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1960.
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A comparison of hemodynamic performance in mehcanical and biological heart valve prostheses
Heart valve prostheses are used to replace heart valves in patients afflicted with valvular heart disease. The malfunctioning heart valve adversely affects the fluid mechanical performance. While the choice of mechanical VS biological valve prostheses is dependent on the patient, the biological …
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Development of a Tubular Biological Tissue-Engineered Heart Valve with Growth Potential
… their immunogenicity. An allogeneic tubular heart valve was fabricated by inserting one engineered tube inside of another and attaching them together using degradable sutures. Extensive hemodynamic testing was performed in order to optimize and verify valve design. The growth potential and in …
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Fluid¿Structure Interaction Modelling for the Biomechanical Study of Heart Valve Prostheses
L'abstract è presente nell'allegato / the abstract is in the attachment
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Multiscale simulations of the aortic heart valve : applications in disease and surgery
… the mechanical behavior of the human aortic heart valve over a range of length and time scales. In the human heart, the valves perform the vital function of controlling the direction of blood flow. Each valve is an intricate mechanical structure, with distinct features and functions at …
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Development, testing, and evaluation of the central-flow, double- leaflet heart valve
… the literature revealed that 1) all prosthetic heart valves to date are plagued by certain problems, 2) all prosthetic valves in current clinical use are central-occlusion valves which do not effectively simulate natural valve action, and 3) the development of a true central-flow valve with the …
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Design and development of an electrospun polymeric transcatheter heart valve for tissue engineering
The growing global burden of valvular heart disease (VHD) remains a significant challenge to overcome. Despite the advancements in heart valve replacements and the ground-breaking introduction of transcatheter valve technologies, current solutions offer suboptimal therapy as they either require …
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Development of a fatigue tester and material model for flexible heart valve applications
The leaflet material in heart valve prostheses is required to be both flexible and durable to eliminate the need for chronic anticoagulation medication and accommodate younger patients with longer life expectancies. This investigation aims to provide two of the necessary tools to design and test …
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Fatigue life modelling of anisotropic styrenic block copolymers for a prosthetic heart valve application
… tested for a flexible leaflet aortic prosthetic heart valve, designed to mimic the native structure of the aortic leaflet. Polymeric valves have the potential to overcome the limit of current available prosthesis, however no such valve is available clinically at present. Durability and …
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Mitigation of the inflammatory response to bioprosthetic heart valve tissue through antigen-directed masking
… the immune response to bioprosthetic heart valves in patients as well as in animal models. The study further demonstrated that the glutaraldehyde concentration applied to commercial heart valves is insufficient to mask the antigenicity of the tissue, therefore an method of masking …
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Some investigations to compare the durability and performance of mechanical and porcine heart valve prostheses
… to assess the performance and durability of heart valve prostheses. Frcm 1975 to 1979 540 patients undergoing heart valve replacement in Edinburgh Royal Infirmary were entered into a randomised trial and received either a mechanical (Bjork-Shiley), or porcine heterograft (Hancock or …
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