Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"heart structure"”.
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The Role of STIM1 in Hypertrophy-Related Contractile Dysfunction
… by disease conditions results in remodeling of heart structure by hypertrophy and alterations in the molecular regulation of contractile performance. These adaptations can be regulated by various Ca2+-dependent signaling processes. STIM1 is an important regulator of Ca2+ signaling in different …
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Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy
… that contact between TF and blood within the heart can exacerbates the hypertrophic response.Moderate concentrations of TF were found to induce proliferation In H9c2 cardiomyocytes, while high concentrations of TF resulted in increased cellular apoptosis as detected by caspase-3 activation but …
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Backscatter and Attenuation Characterization of Ventricular Myocardium
… measurements of the myocardium in fetal hearts and adult human hearts with the goal of studying the physics of sound waves incident upon anisotropic and inhomogeneous materials. Ultrasound has been used as a clinical tool to assess heart structure and function for several decades. The …
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Defining a role for the cystic fibrosis transmembrane conductance regulator in the heart
… and systems throughout the body. Concerning the heart, right ventricular dysfunction secondary to pulmonary abnormalities has long been recognized. However, the issue as to whether loss of CFTR function causes primary disturbances in the heart has remained an unsolved and often debated question. …
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Chronic Treatment of TMAO Undermines Mouse Cardiac Structure and Function in a Sex-specific Manner
… of mortality and morbidity worldwide, often with heart failure as the terminal stage. Clinical studies have associated elevated levels of trimethylamine N-oxide (TMAO), a gut-derived metabolite, with adverse outcomes of CVD. As of today, TMAO's effects on cardiac structure and function are not …
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A multi-lineage in vitro mouse embryo model derived exclusively from mouse embryonic stem cells
… effectively replace TSCs to form embryo-like structures. The resulting ‘EiTiX-embryoids’ underwent development from pre-gastrulation stages to neurulation stages, developing headfolds, a beating heart structure, and extraembryonic tissues, including a yolk sac and chorion. Further single-cell …
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Later Life Consequences of Subteratogenic Exposure to a Complex PAH Mixture in the Atlantic Killifish (Fundulus heteroclitus)
… certain individual PAHs and PAH mixtures cause heart alterations with decreased swimming capacity in adult fish. Consequently, the heart and cardiorespiratory system are thought to be targets of PAH mixture exposure. While many studies have investigated acute, teratogenic PAH exposures, few …
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Exploring the sex-specific programming of cardiovascular disease by maternal obesity and assessing potential interventions to the mother
… phenotypes of the 8-week-old offspring heart in response to maternal obesity may help to explain the different outcomes observed in male and female risk of developing cardiovascular disease. Chapter 4 shows that maternal obesity induced sex-specific changes in the lipidome of the fetal …