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Showing 1 to 13 of 13 for “"heart regeneration"”.
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Heart Regeneration: An Evolutionary Tale
… pre-existing cardiomyocytes. The adult mammalian heart lacks any meaningful endogenous regenerative response following injury. However, embryonic mammalian cardiomyocytes are proliferative and exit the cell cycle shortly after birth. The question of whether the mammalian heart lacks this …
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Organ-Level Communication During Heart Regeneration In Zebrafish.
<p>Tissue regeneration has been primarily investigated as local remodeling events in response to tissue damage or loss. Recent studies, however, indicate that uninjured structures can respond to distant tissue trauma and, in some cases, regulate tissue regeneration. One of the key questions that …
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Transcriptional Regulation of Neonatal Heart Regeneration and Direct Cardiac Reprogramming
The adult mammalian heart has limited capacity for regeneration following injury, whereas the neonatal heart can readily regenerate within a short period after birth. Deciphering the molecular underpinnings of neonatal heart regeneration and the blockade to regeneration in later life may provide …
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Investigating the role of macrophages in larval zebrafish heart regeneration
… in the left ventricle. Unfortunately, the human heart is unable to replace these lost cardiomyocytes, and this can lead to heart failure. In contrast, zebrafish can completely regenerate their hearts after cardiac injury via dedifferentiation and proliferation of surviving cardiomyocytes. …
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Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules
… strategies aimed at inducing myocardial regeneration after cardiac damage. Previous high throughput screening studies in our laboratory identified a series of microRNAs able to trigger cardiomyocyte proliferation and stimulate cardiac regeneration after myocardial infarction. In the first …
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Danio rerio (Hamilton, 1822) širdies ir kraujagyslių sistemos vystymosi ir regeneracinių mechanizmų tyrimai /
… investigation of cardiovascular development and regeneration. However, conditional mutagenesis, which is essential for dissecting a role of developmental genes in regeneration, has not been demonstrated in the adult zebrafish. This remains a main disadvantage of D. rerio model system. The main …
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Studying the mechanisms of cardiovascular development and regeneration in Danio rerio (Hamilton, 1822) /
… investigation of cardiovascular development and regeneration. However, conditional mutagenesis, which is essential for dissecting a role of developmental genes in regeneration, has not been demonstrated in the adult zebrafish. This remains a main disadvantage of D. rerio model system. The main …
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Functional analysis of tcf21 and tbx20 in zebrafish
… opposed to mammals, are able to regenerate new heart cells without significant scar tissue. Heart attacks, a leading cause of death in the United States, leave behind substantial scar tissue that weakens the heart and leads to a greater chance of a repeated cardiac event. Many genes and major …
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miR-322/503 Cluster Drives Cardiac Differentiation by Inhibiting CUG-binding Protein 1
… may lead to better approaches in promoting heart regeneration after injury. MicroRNAs (miRNAs) involved in the process are particularly interesting due to their small profile and relatively shorter path to clinic. With Mesp1 as the marker, we used a Mesp1-Cre/Rosa-EYFP reporter system to …
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BNC1 Regulates Human Epicardial Heterogeneity and Function
… heterogeneous cell layer covering the heart, crucial to correct cardiovascular development. Following epithelial-to-mesenchymal transition (EMT), epicardial cells migrate into myocardium, form coronary smooth muscle cells and cardiac fibroblasts, and instruct cardiomyocytes to …
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Investigating CDK9 inhibitor treatment during the innate inflammatory and regenerative response in a zebrafish model of cardiac injury
… however, their effects on cardiac repair/regeneration are unknown. Unlike adult mammalian hearts, zebrafish hearts regenerate following injury via cardiomyocyte proliferation. Prolonged neutrophil retention has been shown to impair cardiomyocyte proliferation and myocardial wound …
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Blood plasma-mediated effects on regenerative features of a novel adult human cardiac stem cell population
… to a progressive decline in organ function and regeneration considered as the ageing process. Several age-associated diseases such as cardiovascular- and neurodegenerative diseases or cancer are described along with their cellular pathologies. Although tissue regeneration substantially relies on …
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Cellular and Molecular Mechanisms of Cardiac Chamber Maturation in Zebrafish
<p>The formation of the heart is a critical part of development that, if defective, can lead to congenital malformations incompatible with life. An improved understanding of the cellular and molecular processes that build the heart is essential to elucidate the causes of congenital defects and to …