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Showing 1 to 6 of 6 for “"heart preservation"”.
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Donor heart preservation for heart transplantation
Heart transplantation has enjoyed a spectacular success over the past 25 years. Prior to 1980 less than 350 operations were carried out with an overall one year survival of less than 60%. In 1995 more than 3,000 transplants were performed with a one year survival of 83%. However, growth and …
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Pharmacological activation of pro-survival pathways as a strategy for improving donor heart preservation
… the development and use of specialised cardiac preservation solutions, the quality of the donor heart may still be compromised by its obligatory exposure to periods of ischaemia (both cold and warm) followed by reperfusion upon reintroduction of the recipient circulation. This is reflected in …
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In-Silico design and verification of an extracorporeal normothermic cardiac perfusion system for use during heart transplantation procedures
Heart transplantation relies on effective donor organ preservation to ensure successful graft viability. Since the first human heart transplant in 1967 by Christiaan Barnard, organ preservation techniques have evolved from static cold storage with cardioplegic arrest to continuous blood perfusion, …
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In-Silico design and verification of an extracorporeal normothermic cardiac perfusion system for use during heart transplantation procedures
Heart transplantation relies on effective donor organ preservation to ensure successful graft viability. Since the first human heart transplant in 1967 by Christiaan Barnard, organ preservation techniques have evolved from static cold storage with cardioplegic arrest to continuous blood perfusion, …
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Enhancing Metabolism of Donor Hearts for Cardiac Transplantation
Congestive heart failure is a major health problem that affects millions of patients and represents a major cost to the health care system. Heart transplantation remains the most effective treatment for end-stage heart failure. However, transplantation can only be offered to a small fraction of …
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Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model.
… cardioplegic storage, or in the future during preservation of donor hearts by perfusion, monitoring of the donor heart before transplantation may be of benefit. We hypothesized, that myocardial microdialysate glycerol will reflect progressive damage. As the first step in pursuing this, in the …