Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"haloperidol"”.
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Mechanism of Action of Antipsychotics, Haloperidol and Olanzapine in vitro
… 1-1.5% of people in the United States alone. Haloperidol (HP), a butyrophenone and a typical antipsychotic, has been used as an antipsychotic drug in human. Unfortunately, the therapeutic effects of HP also come with severe extrapyramidal side effects, resulting in movement disorders in …
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Psychomotorische Leistungsfähigkeit und Fahrtauglichkeit bei schizophrenen Patienten unter Risperidon versus Haloperidol
… untersucht. Es wurden jeweils 20 Patienten mit Haloperidol bzw. Risperidon Monotherapie mit einer gesunden Kontrollgruppe verglichen. Anhand standardisierter Tests wurde die visuelle Wahrnehmungsfähigkeit, Aufmerksamkeitsleistung, Reaktionszeit, reaktive Dauerbelastbarkeit, Aufnahme- und …
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Studies on the metabolic bioactivation of haloperidol (HP) and its tetrahydropyridine dehydration product
Haloperidol (HP), a member of the butyrophenone class of neuroleptics and a first choice for the treatment of schizophrenia, causes severe extrapyramidal side effects including acute dystonic reactions, akathisia, drug-induced parkinsonism and, following chronic treatment, tardive dyskinesias (TD). …
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Haloperidol-Environment Interaction Modulates Expression of c-Fos Proteins in the Basal Ganglia in Rats
… in the Paired group (n = 10) were injected with haloperidol (0.25 mg/kg) and initially descended almost immediately but over days descent latencies grew longer. Control rats were tested daily and received haloperidol (Unpaired group, n = 9) or saline (Saline group, n = 10) later in their home …
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EFFECTS OF REPEATED ARIPIPRAZOLE TREATMENT ON THE cAMP AND AKT PATHWAYS IN THE DORSAL STRIATUM OF PREADOLESCENT AND ADULT RATS
… First-generation antipsychotics, such as haloperidol, are D2-like antagonists that can cause severe extrapyramidal effects. Aripiprazole, a dopamine and serotonin partial agonist, has fewer side effects, making it tolerable for adults and children. Extrapyramidal effects (e.g. …
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Erhebung pharmakokinetischer Daten von Cisaprid, SC-72393, Haloperidol, Linezolid, Methotrexat und Ketoprofen nach Methodenentwicklung und Validierung durch LC-MS/MS-Detektion
… wurden für die Wirkstoffe Cisaprid, SC-72393, Haloperidol, Linezolid, Methotrexat und Ketoprofen LC-MS/MS-Methoden entwickelt oder via unabhängiger Laborvalidierung auf die lokalen Gegebenheiten transferiert und zur Bestimmung pharmakokinetischer Parameter zur Anwendung gebracht. Ziel der …
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Dopamine D1-Like, D2 and D3 Receptor Subtypes in Catalepsy Sensitization and Conditioning in Rats: Implications for Motor Function, Motivation and Learning
… dose of the D2 receptor-preferring antagonist haloperidol do not initially exhibit catalepsy, a response quantified by time spent on a horizontal bar without active movement. However, with repeated drug-environment pairings animals show a reduction in exploration and increases in catalepsy. The …
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Behavioral and Electromyographic Comparisons of Neuroleptic and Opiate Catalepsy in Rats
My experiments demonstrate that morphine and haloperidol produce two distinct and contrasting behavioral states, which can be thought of as exaggerated, isolated, and simplified forms of organized adaptive behavioral states functioning as components of normal motivated behavior. Haloperidol ca
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Pharmacological Intervention Reduces Hippocampal Hyperactivity in a Mouse Model of Psychosis
… used in these studies. The drugs used were haloperidol - a classic antipsychotic, and levetiracetam - anticonvulsant with proven pro-cognitive effect, but experimental in the field of psychosis. In Chapter 4, I have examined the effects of subchronic Compound 21 administration one week after …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΚΕΤΑΜΙΝΗΣ ΣΤΟ ΜΕΛΑΙΝΟΡΑΒΔΩΤΟ ΝΤΟΠΑΜΙΝΕΡΓΙΚΟ ΣΥΣΤΗΜΑ ΤΟΥ ΕΓΚΕΦΑΛΟΥ
… AMPHETAMINE (2 MG/KG), APOMORPHINE (0,5 MG/KG), HALOPERIDOL (0,5 MG/KG), ATROPINE (1 MG/KG), AMPHETAMINE+KETAMINE, APOMORPHINE+KETAMINE, HALOPERIDOL +KETAMINE, ATROPINE+KETAMINE. KETAMINE AND AMPHETAMINE, AS WELL AS THEIR COMBINATION, INDUCED IPSIVERSIVE TURNING, WHILE APOMORPHINE, HALOPERIDOL …
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The Prevalence Of Metabolic Disorders And Their Associated Risk Factors In Forensic Patients With Schizophrenia Spectrum Disorders On Clozapine Compared To Haloperidol At Valkenberg Hospital
… clozapine (study group) compared to patients on haloperidol (control group). Methods: It is a retrospective, folder review of forensic male adult patients at Valkenberg Hospital, Observatory Cape Town. Results: There were 45 patients in the study group and 23 patients in the control group. Eight …
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The Nursing Experience of Chemical Sedation in the Elderly
… they chemically sedate an elderly patient with haloperidol. Eight experienced registered nurses with interviewed with open-ended questions that asked them to describe a behavioral crisis in an elderly patient and it’s culmination in giving haloperidol intramuscularly. They were then asked to …
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Antipsychotic drugs for the treatment of acute schizophrenia after the first episode
… for weight gain (p=0.03), olanzapine and haloperidol for weight gain (p<0.001) and akathisia (p=0.0003), haloperidol and quetiapine for akathisia (p=0.02), haloperidol and ziprasidone for weight gain (p=0.03) and olanzapine and ziprasidone weight gain (p<0.001). Total discontinuation after …
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Serotonergic and dopaminergic systems as targets for exogenous neurotoxins causing a parkinsonian syndrome
… and compared it to the mechanism of action of haloperidol metabolites, some of which are found in schizophrenic patients. Experiments assessed the effects of these compounds on several aspects of amine uptake in mouse brain synaptosomes. Both MPTP and MPP⁺ were inhibitors of labeled …
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Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area
… 2017 for the cash price of a 30-day supply of haloperidol 10 milligrams (30 tablets), risperidone 4mg (30 tablets), olanzapine 20mg (30 tablets), quetiapine 300mg (60 tablets), ziprasidone 80mg (60 tablets), and aripiprazole 20mg (30 tablets). Each pharmacy was then classified as being either a …
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A Dual Approach of Salt Formation and Amorphous Solid Dispersion for Improved Oral Drug Delivery
… class II drugs, clofazimine, aripiprazole, and haloperidol, were selected as model drugs. Ten salts of each drug were prepared with counterions with ΔpKa> 3 using a rotary evaporator and characterized for thermal analysis, structural analysis, and equilibrium drug solubility. Clofazimine …
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Modulación de la respuesta de sobresalto por factores asociativos y emocionales
… efecto de agonista -anfetamina- y antagonista -haloperidol- dopaminérgicos con un contexto determinado. Este tipo de estudio se dividió en dos experimentos. En el primero de ellos se les inyectó a las ratas anfetamina junto al haloperidol, a continuación, eran introducidas en una caja …
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