Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"halogenases"”.
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Crystallographic studies on enzymatic halogenation of natural products
… solve structures of enzymes from two classes of halogenases, the flavin-dependent halogenases and the non-heme iron dependent halogenases. Structures of the flavin-dependent tryptophan 7-halogenase RebH from Lechevalieria aerocolonigenes, involved in rebeccamycin biosynthesis, were solved by …
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Computational Investigation of the Catalytic and Structural Roles of Metals in Metalloenzymes
… halogenation catalyzed by non-heme iron halogenases. Demonstrating the utility of this protocol, our simulations provide essential insights on the interplay between strategic substrate positioning, active-site configurational isomerization, and protein dynamics in halogenases SyrB2, WelO5 …
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Two versatile cofactors, flavin adenine dinucleotide and non-heme iron, involved in DNA repair and natural product halogenation
… perform halogenation chemistry. Flavin-dependent halogenasess perform halogenation reactions on aromatic substrates, while non-heme iron-dependent halogenases perform halogenations reactions on unactivated aliphatic substrates. I is a flavin-dependent halogenase that catalyzes the chlorination of …
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Reprogramming alkaloid biosynthesis in Catharanthus roseus : synthetic biology in plants
… ability to produce halogenated compounds. These halogenases function within the context of the plant cell to generate halogenated precursor, which is then shuttled into MIA metabolism to yield halogenated alkaloids. Altogether, a new functional group-an organohalide-was introduced into plant …
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Interplay of Transition Metals and Noncovalent Interactions in C–H Activation Catalysis
… complex (TMC) active sites in non-heme iron halogenases and hydroxylases. Due to the fleeting nature of the ferryl intermediate, experimentalists tend to use vanadyl mimics in order to better understand the ferryl intermediate. However, these metals exhibit distinct electronic structure, …
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Halogenasen aus Actinomyceten : funktionelle und phylogenetische Studien
Actinomyceten produzieren eine enorme Vielfalt unterschiedlichster biologisch aktiver Sekundärmetabolite, die für die Suche nach neuen Medikamenten eingesetzt werden können. Die Nutzung dieser Ressource im Wirkstofffindungsprozess ist jedoch nicht trivial und meist recht aufwendig. Daher ist trotz …
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A Convenient Synthesis of Pyrrolnitrin and Related Halogenated Phenylpyrroles
This thesis details a straightforward synthetic route to the antifungal compound pyrrolnitrin 1.2, along with several analogous halogenated phenylpyrroles. The proposed synthetic protocol involved the Suzuki-Miyaura cross-coupling of appropriately halogenated pyrrole pinacolboronate esters and aryl …