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Showing 1 to 3 of 3 for “"halofluorination"”.
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Development of Fluorine-18 Halofluorination and Fluorine-18 Fluoride Ion Displacement Reactions for the Synthesis of Fluorine-18 Labeled Radiopharmaceuticals (Spiperone, Spiroperidol, N-Alkylation, Radioactivity)
Two fluorine-18 labeling methods, ('18)F halofluorination and ('18)F fluoride ion displacement reactions, have been developed to assess their potential for labeling molecules with the positron-emitting radionuclide fluorine-18 at the no-carrier-added level.
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I. Facile preparation of ortho-fluorophenols from non-aromatic precursors and investigation of applications to fluorine-18 labeling II. Resin-supported silyl ester precursors for kit-like radiolabeling with fluorine-18
… We have found that α-diazocyclohexenones undergo halofluorination with fluoride ion as fluoride source, and the following hydrohalide elimination and tautomerization afford ortho-fluorophenols rapidly. The translation to F-18 radiolabeling was achieved using organic soluble phase transfer …