Global ETD Search
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Showing 1 to 6 of 6 for “"haloduracin"”.
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Biosynthesis of the Polycyclic Antimicrobial Peptides Lacticin 481, Haloduracin, and Cinnamycin
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.
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Investigation of the Enzymes Involved in Lantibiotic Biosynthesis: Lacticin 481 and Haloduracin
Finally, removal of the leader peptide from the modified precursor peptides is the final step in the maturation of lantibiotics, and is required for achievement of full biological activity. In lacticin 481 maturation, this peptide cleavage reaction is performed by the N-terminal protease domain of …
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Biosynthesis and mode of action of ribosomally synthesized and post-translationally modified antimicrobial peptides
… peptides. In Chapter 2, it is demonstrated that haloduracin, a recently discovered two-peptide lantibiotic, possesses nanomolar antimicrobial activity against a panel of bacteria strains. The potency of haloduracin rivals that of nisin, an economically and therapeutically relevant lantibiotic, …
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Biosynthesis and engineering of lanthipeptide natural products for novel applications
… in Chapter 5 focus on the mode of action of haloduracin (Halα and Halβ), a two-component lanthipeptide bacteriocin (termed lantibiotic) that act in synergy to exhibit antimicrobial activity. It was previously proposed for the two-component lantibiotics that the α and β peptides recognize …
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The biosynthesis and discovery of lanthipeptides
Natural products and their derivatives have been significant resources for the development of therapeutic compounds. They attracted interests from both academia and industry because of their high structural diversity and potential applications. Lanthipeptides are one class of natural products that …
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New chemical and biosynthetic methodologies for the study of lanthipeptides
Recent genome sequencing efforts have revealed that a common biosynthetic route to peptide natural products involves ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the largest classes of RiPPs is the lanthionine-containing peptides (lanthipeptides), which are …