Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 472 for “"half-life"”.
-
High-Precision Half-Life Measurement of Oxygen-14
… (CKM) quark-mixing matrix. A high precision half-life measurement for one of these superallowed emitters,14O, has been performed in 2017 at the Isotope Separator and Accelerator (ISAC) facility at TRIUMF. The half-life of 14O was deduced using a 4π gas-filled proportional counter and fast …
-
A test of the half-life of Rb87
Thesis. (M.S.)--Massachusetts Institute of Technology, Dept. of Geology and Geophysics, 1957.
-
The Determination of the Half-Life of Si-32 and Time Varying Nuclear Decay
… work is to make an accurate determination of the half-life of $^{32}$Si as well as to investigate reported variations in nuclear decay rates. Primarily, we focus on a previous experiment at Brookhaven National Lab (BNL) \cite{BNL}, which measured the ratio of interwoven $^{32}$Si and $^{36}$Cl …
-
Study of unsuspected gamma ray energy peaks observed during the determination of the half-life of activated aluminium
In the experimental determination of the half-life of the decay of a radioactive element, an aluminium cylinder is activated through immersion in a thermal neutron bath. The decay of the irradiated aluminium cylinder is then measured to determine the half-life of the resultant 28Al. During the …
-
Characterization of AG10, a potent stabilizer of transthyretin, and its application in enhancing in vivo half-life of therapeutic peptides
… harnessing TTR as a platform to enhance in vivo half-life of therapeutic peptides. The tremendous therapeutic potential of peptides has not yet been realized, mainly owing to their short in vivo half-life. Although conjugation to macromolecules has been a mainstay approach for enhancing protein …
-
Cationic amphiphilic drug-induced autophagosome accumulation is due to autophagosome sequestration within vimentin intermediate filament networks resulting in prolonged autophagosome half-life
… U18666A or clozapine had an</p> <p>estimated half-life of ~0.7, 2.5, 29 and 26 h, respectively. Shifting U18666A treated cultures to leucine-starvation media enhanced autophagosome</p> <p>clearance (half-life ~2.6 h), without effecting non-esterified cholesterol content</p> <p>suggesting …
-
Synergistic anti-tumor immune response to combination immunotherapy consisting of anti-tumor antibodies, extended half-life Interleukin-2, and other immunomodulatory agents
Cancer immunotherapies under development have generally focused on either stimulating T-cell immunity or driving antibody-directed effector functions of the innate immune system such as antibody-dependent cell-mediated cytotoxicity (ADCC). However, as our understanding of antitumor immune responses …
-
Molecular mechanism of action of the glucocorticoid receptor:Role of ligand-dependent receptor phosphorylation and half-life in determination of ligand-specific transcriptional activity. : Contents Pages
… both ligand-selective GR phosphorylation and half-life were found to correlate with efficacy for transactivation and transrepression of model synthetic reporter genes, where agonists resulted in the greatest extent of phosphorylation and the fastest vii rate of GR turnover, suggesting a link …
-
Measurement of the double beta decay half-life of ^{100}Mo to the 0^{+}_{1} excited state, and ^{48}Ca to the ground state in the NEMO 3 experiment
… to the ground state of ^{48}Ti. The two neutrino half-life measurement for ^{100}Mo is found to be T^{2\upsilon}_{1/2}(O^+\rightarrow O^{+}_1}) = 5.70^{+1.15}_{-0.82} (stat) \pm 0.77 (syst.) \times 10^{20} yrs. This being the first result where all the final states have been measured. For ^{48}Ca, …
-
The relationship between journal use in a medical library and citation use
… impact factor, citation age and citation half-life were obtained from Journal Citation Reports (JCR) 1993 microfiche edition. Only 835 journals which were in JCR and in the library were compared. The correlation between use frequency and citation frequency and between use frequency and …
-
Development and Characterization of a Novel Protein Stability Probe
… of gene transcription, (MYC) modulates cell proliferation, growth, and metabolism. The deregulation of c-MYC (MYC) drives over 50% of cancers, making it a promising therapeutic target. Unfortunately, traditional approaches to target MYC have been unsuccessful. MYC turnover is tightly regulated, …
-
Medical Isotope Production of Actinium 225 By Linear Accelerator Photon Irradiation of Radium 226
… method utilizes the alpha-decay of both Ac-225 (half-life 10 days) and Bi-213 (half-life 46 min) to kill cancerous cells on a localized basis. Maximum energy is delivered to the cancer cells thereby greatly minimizing healthy tissue damage. This research proposes a production method using a …
-
ΜΕΛΕΤΗ ΤΗΣ ΒΙΟΙΣΟΔΥΝΑΜΙΑΣ ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ ΠΟΥ ΚΥΚΛΟΦΟΡΟΥΝ ΣΤΗΝ ΕΛΛΑΔΑ
… ), MAXIMUM CONCENTRATION (T MAX), ABSORPTION HALF LIFE (T 1/2/ KA) AND ELIMINATION HALF LIFE (T 1/2 /KE). IT WAS PROVED THAT (1) NONE OF THE ABOVE PRODUCTS EXHIBITS SIGNIFICANT PHARMACOKINETIC DIFFERENCES COMPARED TO THE OTHERS, (2) ALL THE PRODUCTS STUDIED CONTAINED THE PRESCRIBED AMOUNT OF …
-
The Development of Methods for Generating Fc-Conjugates and Antibody-Drug Conjugates
… characteristics, such as a long circulation half-life, the ability to target tumours and engaging the immune system; therefore, antibodies can be exploited as therapeutics by attaching small molecules or peptide drugs. Section I of this thesis describes the design, synthesis, and …
-
Antibody engineering for tumor immunotherapy
… also quite stable, with a cell-surface shedding half-life of approximately 7 days. Directed evolution methodology has been utilized to design an antibody fragment with properties that would improve tumor retention. Specifically, antibody engineering methods were used to produce a humanized, …
-
Double-Beta Decay of 96Zr and Double-Electron Capture of 156Dy to Excited Final States
… years of data with 17.91 g of enriched 96Zr, half-life limits at the level of 10^20 yr were produced. Measurements of this decay are important to test neutrinoless double-beta decay nuclear matrix element calculations, which are necessary to extract the neutrino mass from a measurement of the …
-
The Effect of Microwave Energy on Sintering
… radioactive actinides which have an average half-life of several thousand years (e.g. Plutonium-239 with a half-life of 24,000 years, and Americium-243 with a half-life of 7,360 years). Several multinational organizations are making an attempt to extract the energetic value out of these …
-
The Characterization of Cx31 in Keratinocytes and its Link to Erythrokeratodermia Variabilis et Progressiva
… variabilis et progressiva. We investigated the life-cycle of Cx31 and its interplay with co-expressed Cx26, Cx30 and Cx43 in rat epidermal keratinocytes. We demonstrated that the apparent half-life of Cx31 was extended compared to Cx43, and that Cx31 gap junctions persisted longer at the cell …
-
Dependence of transuranic content in spent fuel on fuel burnup
… in unit mass. The net result is that the half-life of high burnup fuels is greatly increased in comparison to low burnup fuels for the first decade of life. Beginning from day 14 after shutdown and until 10 years later, the 100 MWD/kg fuel has a half-life of 129 days while the 30 MWD/kg …
-
Pharmacokinetics of a high-concentration formulation of buprenorphine (Simbadol®) in male dogs
… and 5.7 (61) mL minute−1 kg−1. The absorption half-life for the fast absorption phase was 8.9 minutes with a 0.7 (103) minute delay. The absorption half-life for the slow absorption phase was 347 minutes with a 226 (42) minutes delay. Median (range) bioavailability calculated from …
Page 1 of 24