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Showing 1 to 5 of 5 for “"hairpin ribozyme"”.
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Dynamics of Hairpin Ribozyme
… molecule spectroscopy to study the dynamics of hairpin ribozyme---an enzymatic RNA molecule capable of cleaving phosphodiester linkage. RNA controls key processes of gene expression. Ribozymes can catalytically edit precursor RNA message transcribed from DNA, the edited RNA then carries the …
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Single molecule fluorescence and force spectroscopy of hairpin ribozyme
Submitted by Elizabeth Kent (eckent2@illinois.edu) on 2012-06-07T18:47:11Z No. of bitstreams: 1 2006_nahas.pdf: 5361832 bytes, checksum: 0d81d12a930597d8c5ce651d401a9bd7 (MD5)
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Laser-assisted single-molecule refolding
… trapped RNAs. The application of LASR to kissing hairpins has allowed us, for the first time, to drive a molecular reaction and monitor the process at the single molecule level. The melting curve for the dissociation and dimerization was used to estimate the thermodynamic properties of the …
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Exploring Novel Techniques for the Single Molecule Toolkit: Vesicle Encapsulation and Immobilization
… of the local surface. A striking example is the hairpin ribozyme which was shown---in our lab---to exhibit two orders of magnitude variation in folding/unfolding kinetics between molecules. Moreover, a DNA with a sequence of human telomeric repeat exhibited extreme conformational diversity among …
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Enhancement of anti-HIV-1 Ribozyme Activities by Rev Binding and Multimerization
<p>To effectively apply hammerhead ribozymes as therapeutic agents it is necessary to co-localize them with the desired target. Human immunodeficiency virus type1 (HIV- 1) infectivity is dependent on <em>env</em> gene expression. HIV-1 Rev protein binds to a higher ordered RNA structure within the …