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Showing 1 to 9 of 9 for “"hair follicle stem cells"”.
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Specification And Function Of Early Hair Follicle Stem Cells
<p>In adult skin, multipotent epithelial stem cells (SCs) reside in a quiescent niche associated with each hair follicle termed the "bulge" and are essential for cyclic bouts of hair growth. Bulge stem cells can also contribute to sebaceous glands and the intefollicular epidermis when it is …
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Serine Metabolism Leverages the Integrated Stress Response to Direct Stem Cell Fate During Tissue Regeneration
<p>Epidermal stem cells constantly rejuvenate the skin's barrier, which excludes harmful microbes and prevents dehydration. While hair follicle stem cells (HFSCs) normally regenerate hair, they must also reconstruct and thereafter maintain the overlying epidermis upon a barrier breach, such as a …
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Pioneer Factors Compete for Epigenetic Factors in Switching Stem Cell Fates
<p>During development, progenitor cells can activate one cell fate while simultaneously silencing another, a process that is tightly regulated in adult tissues. However, this process is often derailed in diseases such as cancers, leading to uncontrolled growth and malignancy. At the crossroads of …
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Molecular Regulation of Hair Follicle Morphogenesis
… from a single uniform layer of multipotent cells during embryogenesis. Morphogenesis of hair follicles is initiated when a series of reciprocal interactions between this undifferentiated ectoderm and its underlying mesenchyme leads to a localized invagination of epithelial cells. As hair …
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Coordinating Stem Cell Behavior in the Hair Follicle
<p>Tissue stem cells perform important functions throughout an organism's life. They generate new cells to replenish cells that are lost during normal wear and tear or in response to acute injury. Remarkably, hair follicles naturally undergo repetitive cycles of regeneration and degeneration, a …
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Transcriptional functions of the corepressor Sin3A in skin
Upon activation in epidermal stem cells, the proto-oncogene c-Myc triggers their exit from the stem cell compartment resulting in an increase in progenitor cell proliferation and an induction in terminal differentiation. Whether c-Myc plays a direct transcriptional role in epidermal stem cell …
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Home Sweet Home: Epigenetic Paths of Stem Cells In and Out of Their Niche
<p>Adult stem cells reside in niches, which control their long-term ability to selfrenew and produce the differentiated cell lineages necessary to regenerate and repair their tissues. Following injury, culture or transplantation, stem cells outside their niche often acquire broader plasticity in …
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Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration
<p>Adult stem cells are endowed with the remarkable ability to maintain, regenerate and repair tissues throughout the lifetime of the organism. Whether parsimonious utilization of adult stem cells is necessary to preserve their long-term potential has not been fully explored. I investigated this …
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Unravelling novel molecular targets for photobiomodulation in human hair follicle towards the development of more effective light-based therapies for hair growth
… time and optical properties of tissue and cells. Last decade experienced a growing rise of commercial devices for management of hair growth, where all of them are based on low levels of light resulting into photobiological, non-thermal interaction of photons with cells, a process that …