Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 123 for “"hair cells"”.
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Light Stimulation of Sensory Hair Cells
<p>Hair cells are the mechanosensory detectors that underlie our senses of audition and balance. Their mechanosensitivity arises from direct gating of force-sensitive ion channels by the tension in tip links located at the tops of the stereocilia. The study of hair cells and their mechanically …
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Sodium entry pathways in isolated goldfish hair cells
Hair cells are the exquisitely-sensitive mechanosensory transducers of the inner ear. While the electrophysiology of hair cells has been extensively studied, little is known about the vital background processes that maintain the steady-state intracellular ionic environment. This study explored …
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The Role of Pkd1 in Mouse Inner Ear Hair Cells
… transduction (MET) channel in inner ear hair cells based on PC-1 role of fluid flow sensing and calcium uptake into renal epithelial cells. However, two independent mouse lines with PC-1 mutations exhibit normal MET channel function despite hearing loss and ultra-structural abnormalities …
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Membrane tether formation from outer hair cells with optical tweezers
The mechanical properties of the outer hair cells (OHCs) lateral wall are essential to elucidate the mechanism of OHC electromotility. Optical tweezers were used to characterize the mechanical properties of OHC plasma membrane (PM) by pulling tethers. A greater force was required for tether …
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A computational approach for understanding adaptation in vertebrate hair cells
Vertebrate hair cells respond to mechanical stimuli with an inward current that is carried by extracellular cations through mechanically-gated transmembrane ion channels called transduction channels, located in the hair cell's specialized apical surface called the stereocilia. The current is …
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Airflow sensing with arrays of hydrogel supported artificial hair cells
Arrays of fully hydrogel-supported, artificial hair cell (AHC) sensors based on bilayer membrane mechanotransduction are designed and characterized to determine sensitivity to multiple stimuli. The work draws upon key engineering design principles inspired by the characteristics of biological hair …
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Gentamicin and FM1-43 enter sensory hair cells through mechanosensory transduction channel
… aminoglycoside antibiotic drugs, into sensory hair cells: permeation through the transduction channels. Both gentamicin, an aminoglycoside, and FM1-43, a styryl pyridinium dye, rapidly and selectively enter hair cells. The hair cell transduction channel passes monovalent cations, but is …
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Frequency Selectivity of Synaptic Exocytosis in Hair Cells of the Bullfrog's Amphibian Papilla
… membrane, the flexible structure that houses hair cells, the auditory receptors. However, in non-mammalian vertebrates, the basilar membrane does not conduct a traveling wave. In some animals, the membrane is absent entirely. Yet auditory fibers from these animals display comparable sharpness …
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Design and Characterization of Biomimetic Artificial Hair Cells in an Artificial Cochlear Environment
… of a new biomimetic artificial inner hair cell sensor in an artificial cochlear environment. Designed to mimic the fluid flows around the inner hair cells of the human cochlea, the artificial cochlear environment produces controlled, linear sinusoidal fluid flows with frequencies …
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The canonical Wnt signaling pathway affects regeneration of mechanosensory hair cells in Danio Rerio
In vertebrates, mechanosensory hair cells are located in the inner ear and mediate hearing. When damage to these specialized cells occur, it leads to irreversible hearing loss. Not only do aquatic vertebrates have inner ear hair cells, but mechanosensory hair cells are also found in the lateral …
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The Reinnervation of Sensory Hair Cells Following Lesion of the Lateral Line Cranial Nerve
… information between the mechanosensitive hair cells of the inner ear and the brain. The restoration of physiologic hearing would require the regeneration of nerve fibers back into the sensory epithelium of the cochlea, followed by the reinnervation of appropriate hair cell targets. Nerve …
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The expression of muscarinc acetylcholine receptors on the avian vestibular hair cells and the modulation effects on KIR2.1
… from the vestibular efferent terminals onto hair cells is acetylcholine (ACh). Two types of acetylcholine receptors (AChRs) have been suggested to be located on hair cells (HCs). They were nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs). Even though pioneering physiological and …
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Gingko biloba extracts protect auditory hair cells from cisplatin-induced ototoxicity by inhibiting perturbation of gap junctional intercellular communication
… and disturbance of GJIC. HEI-OC1 auditory cells were cultured and treated with cisplatin (50μM) and EGb (300μg/ml) for 24 h, and then analyzed by immunocytochemistry (Annexin V/ propidium iodide) and Western blots. The function of GJIC was evaluated by scrape-loading dye transfer (SLDT). …
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Defined populations of inner ear progenitor cells show limited and distinct capacities for differentiation into hair cells, neurons, and glia
Despite the fact that mammalian hair cells and neurons do not naturally regenerate in vivo, progenitor cells exist within the postnatal inner ear that can be manipulated to generate hair cells and neurons. This work reveals the differentiation capabilities of distinct inner ear progenitor …
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THE ROLE OF NOTCH SIGNALING IN THE DIFFERENTIAL ABILITY OF SUPPORTING CELL SUBTYPES TO SPONTANEOUSLY REGENERATE HAIR CELLS IN THE NEONATAL MOUSE COCHLEA
… this loss in hearing is the loss of the sensory hair cells (HCs) within the cochlea. Also in the mammalian cochlea, six major groups of supporting cell (SC) subtypes reside in close proximity to HCs and may have the potential to regenerate HCs after damage. These subtypes include cells of the …
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Development of an Optogenetic Tool for Targeted Sensory Hair Cell Ablation in Zebrafish
Mechanosensory hair cells convert mechanical information into neuronal signals. Mutations in the genes required for hair cell function cause deafness and lead to the degeneration of sensory hair cells. Mammals are unable to regenerate these cells, leading to the permanent loss of hair cells. …
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Regulation of the development and regeneration of the zebrafish posterior lateral line
Mechanosensory hair cells located in the inner ear mediate the sensations of hearing and balance. If damaged, mammalian inner ear hair cells are unable to regenerate, resulting in permanent sensory deficits. Damage to hair cells can arise from multiple factors such as high decibel and prolonged …
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Cochlear hair cell regeneration from neonatal mouse supporting cells
Unlike lower vertebrates, capable of spontaneous hair cell regeneration, mammals experience permanent sensorineural hearing loss following hair cell damage. Although low levels of hair cell regeneration have been demonstrated in the immature mammalian vestibular system, the cochlea has been thought …
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Combination of Compounds A2CE and C18 for Cochlear Hair Cell Regeneration in Adult Mice
… to explore to restore normal hearing function. Hair cells are a specialized cell type in the inner ear that are crucial for transducing sound into electrical signals that our neurons can interpret. They are post-mitotic, which means once they die or are damaged, they do not regenerate. Previous …
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Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin
The hair cell of the inner ear converts mechanical stimuli, such as sound waves, into electrical impulses which are then sent to and interpreted by the brain. Proper organization of the actin and microtubule cytoskeletons is important for establishing the distinct morphology of the hair cell, which …
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