Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 108 for “"hair cell"”.
-
Development of Active Artificial Hair Cell Sensors
… can be detected. In this work, active artificial hair cells (AHC) are proposed and developed which mimic the nonlinear cochlear amplifier. Active AHCs can be used to transduce sound pressures, fluid flow, accelerations, or another form of dynamic input. These nonlinear sensors consist of …
-
Mechanical modeling of vestibular hair cell bundles
Hair cells are transducers found found in the inner ear of vertebrates. They convert a mechanical signal, detected by the deflection of a bundle of cilia extending from their top surface, into an electrochemical signal. This dissertation studies the mechanical influence of the structure and …
-
A feedback analysis of outer hair cell dynamics
Outer hair cells (OHCs) generate active forces in the mammalian cochlea. Acting as cochlear amplifiers, OHCs can counteract viscous drag, generating high gain at characteristic frequencies and allowing for the sharp frequency selectivity and sensitivity observed in mammals. Excitatory displacement …
-
Transfer Properties of the Hair Cell-Afferent Fiber Synapse
… process achieved by the chemical synapses of hair cells in the auditory periphery. Thus, the operation of the hair cell's presynaptic active zone is key to understanding auditory transduction. However, the lack of suitable experimental systems in which to investigate both the presynaptic and …
-
Cochlear hair cell regeneration from neonatal mouse supporting cells
Unlike lower vertebrates, capable of spontaneous hair cell regeneration, mammals experience permanent sensorineural hearing loss following hair cell damage. Although low levels of hair cell regeneration have been demonstrated in the immature mammalian vestibular system, the cochlea has been thought …
-
Regeneration of Hair Cell Epithelia in the Chick and Salamander
… system is characterized by a specific receptor cell type called the sensory hair cell and is found in all vertebrates. There are two types of hair cell sensory epithelia based on location: those of the inner ear, such as the organs for hearing and balance, and the lateral line system located …
-
Decoding Dynamic Gene Regulation in Hair Cell Development and Regeneration
… during the differentiation of specialized cells such as mechanosensory hair cells in vertebrates' inner ears and fishes' lateral lines requires an accurate description of the time-lagged relationships between transcription factors and their target genes. Here I describe <em>De</em>picting …
-
Analysis of Vestibular Hair Cell Bundle Mechanics Using Finite Element Modeling
… canals. Head movement causes deformation of hair cell bundles in these organs, which translate this mechanical stimulus into an electrical response sent to the nervous system. This study consisted of two sections, both utilizing a Fortran-based finite element program to study hair cell bundle …
-
Promotion of Hair Cell Fate by Atoh1 and MicroRNA-183 Family
Hair cells are the mechanoreceptors responsible for hearing and balance in the inner ear. Multiple factors cause hair cell loss including aging, noise exposure and genetic predisposition. A barrier to hearing restoration after hair cell loss is the inability of mammalian auditory hair cells to …
-
Developing Active Artificial Hair Cell Sensors Inspired by the Cochlear Amplifier
… multi-channel and self-sensing active artificial hair cells (AHCs) made of piezoelectric cantilevers and controlled by a cubic damping feedback controller are developed numerically and experimentally. These novel AHCs function near a Hopf bifurcation and amplify or compress the output by a …
-
Auditory Hair Cell Regeneration and Gene Expression in Noise-Exposed Zebrafish (Danio rerio)
Fishes are capable of regenerating sensory hair cells in the inner ear after exposure to excessive noise. However, a time course of auditory hair cell regeneration has not been characterized for zebrafish, nor has gene expression following noise exposure. To establish a time course of hair cell …
-
Characterization of the Key Mouse Cochlear Developmental Genes for Auditory Hair Cell Regeneration
<p>Mammalian inner ear cochlear auditory hair cells (HCs) and adjacent supporting cells (SCs) are believed to derive from the same progenitors during development. However, unlike SCs of nonmammalian vertebrates, mammalian cochlear SCs cannot be converted into functional hair cells (HCs) after …
-
Development of an Optogenetic Tool for Targeted Sensory Hair Cell Ablation in Zebrafish
Mechanosensory hair cells convert mechanical information into neuronal signals. Mutations in the genes required for hair cell function cause deafness and lead to the degeneration of sensory hair cells. Mammals are unable to regenerate these cells, leading to the permanent loss of hair cells. …
-
Patterns of Hair Cell Damage in the Guinea Pig After Intense Auditory Stimulation
Made available in DSpace on 2014-12-08T23:01:55Z (GMT). No. of bitstreams: 1 6910858.pdf: 3490990 bytes, checksum: 34f31bf290776b239cd07f12f5e6bd78 (MD5) Previous issue date: 1968
-
An Open Loop Feed-Forward Control Scheme for Bioinspired Artificial Hair Cell Sensors
… across lipid bilayer membranes in artificial hair cell sensors. Inspired by the human cochlea's non-linear gain phenomenon, whereby the cochlea can increase or decrease the effective gain of the auditory system, this controller is the first step in developing more sophisticated signal …
-
A Computational Study on the Structure, Dynamics and Mechanoelectric Transduction of Vestibular Hair cell
The hair cell, a specialized cell in the inner ear, is responsible for hearing and balance. The hair cell is an exquisite sensor that captures mechanical stimuli and generates neurosensory signals. A theory called gating theory has been developed and widely used to analyze the experimental data of …
-
Combination of Compounds A2CE and C18 for Cochlear Hair Cell Regeneration in Adult Mice
… to explore to restore normal hearing function. Hair cells are a specialized cell type in the inner ear that are crucial for transducing sound into electrical signals that our neurons can interpret. They are post-mitotic, which means once they die or are damaged, they do not regenerate. Previous …
-
Developmental Alterations in the Distribution of Specific Lateral Wall Proteins Modify Outer Hair Cell Mechanical Properties
In the mammalian cochlea, specialized outer hair cells (OHCs) housed within the organ of Corti exhibit nonlinear, mechanical responses to auditory stimulation [1]. These electromotile responses increase hearing sensitivity 100-fold (40 dB) and are responsible for frequency selectivity in the …
-
Genomic Conservation of the Outer Hair Cell Motility Protein, Prestin in the Monotreme: Ornithorhyncus anatinus (Platypus)
The process of outer hair cell (OHC) motility, which enables sound amplification, is an active process that is thought to be unique to mammals. Prestin, the motor protein of these OHCs, is crucial for its function in mammals. Loss of prestin has been found to result in a high-frequency hearing loss …
-
The Role of Peroxiredixin Ⅲ in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cell
… disorders, as well as to tumor promotion. Normal cellular processes that involves oxygen result in the production of reactive oxygen species. Intracellular H2O2 is removed mostly by catalase, glutathione peroxidase, and peroxiredoxin(Prx). The newly identified Prx family of peroxidases includes at …
Page 1 of 6