Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 70 for “"haemolytic activity"”.
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Host-defence peptides from frog skin secretions: identification and bioactivity evaluation and optimisation
… hainanensis) with broad spectrum antimicrobial activity, anti-proliferative activity, and strong haemolytic activity. Two analogues were designed based on the secondary structure. Results revealed that the helical structure is critical for antimicrobial activity and haemolytic activity of …
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Discovery and functional evaluation of a host defense peptide from Rana amurensis
… Fmoc synthesis, and its antibacterial activity, antiproliferative activity and haemolytic activity were tested. QUB-2566 was found to inhibit the growth of S. aureus and E. coli from a peptide concentration of 1µM; however, it required higher peptide concentration to completely inhibit …
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QUB-1453: A Bioactive Peptide from the Defensive Skin Secretion of Rana amurensis
… peptides (AMPs) which have potent bioactivity and pharmaceutical value for new drug development. In this thesis, QUB-1452, an AMP, was isolated and characterised from the skin secretion of Rana amurensis. The peptide is composed of 13 amino acid residues, FLPVLISLIGRLL, and is …
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Discovery and functional study of a bioactive peptide QUB-1892 from the defensive skin secretion of The Edible Frog (Pelophylax eculentus)
… functions such as seen in their antimicrobial activity. In this thesis, a novel Kunitz-like trypsin inhibitor was isolated from the skin secretion of Pelophylax kl esculentus and was named QUB-1892. The mature peptide was synthesised by solid-phase peptide synthesis (SPPS). RP-HPLC and …
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Analysis of a novel antimicrobial peptide QUB-1746 from the skin secretion of the frog, Kassina senegalensis
… by using different micro-organisms and its haemolytic activity was tested by using horse red blood cells. MTT assay tested two human lung cancer cell lines, H23 and H157, for effects. The results of antimicrobial experiments showed that QUB-1746 was active only against the Gram-positive …
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A novel bioactive peptide from the skin secretion of Rana chensinensis
… QUB1735 exhibited potent antimicrobial activity against the growth of Gram-positive bacteria, S. aureus, Gram-negative bacteria, E.coli and the yeast C. albicans with the MIC of 8, 256, 32 µM, respectively. In addition, it also exhibited inhibitory activity against U251MG and H157 cells …
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The discovery of a novel bioactive peptide, QUB-2575, from the defensive skin secretion of Pelophylax kl. esculentus
… QUB-2575 showed antimicrobial and anticancer activity but also had haemolytic activity. The minimal inhibitory concentrations (MICs) of QUB-2575 against three tested microorganisms, S. aureus, E. coli, and C. albicans, were 2 μM, 8 μM, and 4 μM, respectively. The half inhibitory concentrations …
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The discovery of a novel peptide, QUB-2274, from the defensive skin secretion of Rana amurensis
… quantity of a peptide replicate for bioactivity testing, was synthesised by solid-phase peptide synthesis (SPPS). <br/><br/>After these tests, QUB-2274 was found to exhibit differential growth-inhibitory activity towards the Gram-positive bacterium S.aureus, the Gram-negative bacterium …
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A novel dermaseptin peptide from the defensive skin secretion of Phyllomedusa camba
… frogs and they all possess strong an-timicrobial activity with little or no haemolytic activity, which made it possible for the dermaseptin peptides to be considered for clinical development. Phyllomedusa frog skins and their secretions have been researched in the quest for novel peptides like the …
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Assessing bioactivity of a peptide from the skin secretion of Rana amurensis
… that have been evaluated include antimicrobial activity, anticancer activity and haemolytic activity.<br/><br/>Using the technique of ‘shot gun’ cloning, the peptide (FVSLLTNLLGLL.NH2) was found encoded by cloned skin secretion-derived cDNA. The peptide was then synthesised by solid-phase …
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The discovery and bioactivity evaluation of a novel peptide, QUB-1925, and its modified analogue, QUB-2067, from the defensive skin secretion of the frog, Phyllomedusa coelestis
… replicate of QUB-1925 was subjected to bioactivity and toxicity tests. Finally, QUB-1925 was found to have no potent antimicrobial activity against tested microorganisms but to have haemolytic activity at high concentrations. Thus, QUB-1925 was structurally modified to create an analogue …
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Identification, characterization and bioevaluation of a bioactive peptide from the skin secretion of the Chinese forest frog
… Through the study of structure and biological activity, it was found that QUB-1735 was a helical peptide belonging to the Temporin family, and possessed good anti-Gram-positive bacteria activity through the mechanism of membrane destruction. However, its strong haemolytic ability and …
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A bioactive peptide from the skin of the Chinese Torrent Frog, <i>Amolops wuyiensis</i>
… bioactive function of Lividin-AW, a series of bioactivity assays, including antimicrobial assays, cell viability assays, a trypsin inhibition assay and a haemolysis assay, were conducted and the results showed that Lividin-AW exhibited weak antimicrobial activity against Candida albicans …
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Identification, isolation and bioactivity assessment of a novel peptide from the skin of Heilongjiang Brown Frog (Rana amurensis)
… peptide synthesis. Antimicrobial assays and haemolytic assays were operated to investigate its antimicrobial activity, anticancer activity and haemolytic activity.<br/>Synthetic QUB-2207 possesses a potent antimicrobial activity against S. aureus and C. albicans but showed low efficiency …
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The discovery of a novel bioactive peptide, QUB-1036, from the defensive skin secretion of Pelophylax kl. esculentus
… chemical synthesis, QUB-1036 was subjected to bioactivity tests. As a result, QUB-1036 was observed to have no inhibition against microbial growth and was completely devoid of haemolytic activity. It is noteworthy that the novel peptide, QUB-1036, was found to be a bradykinin receptor agonist on …
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A bioactive peptide QUB3009 from the defensive skin secretion of the frog, Phyllomedusa tomopterna
… display vital broad-spectrum antimicrobial activity and have been promoted for the research of novel chemical drugs.<br/><br/>In this thesis, an antimicrobial peptide from the defensive skin secretion of the tiger leg monkey tree frog (Phyllomedusa tomopterna), …
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The functional evaluation of a bioactive peptide, QUB-1998, discovered from the skin secretion of the frog, Pelophylax nigromaculata
… (MIC = 32 µM; MBC = 32 µM).<br/>Meanwhile, its haemolytic activity on horse erythrocytes was lower than 20% at 16 µM. The selective antimicrobial effects that observed indicated that QUB-1998 might deserve further exploration.<br/>
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A bioactive peptide QUB2177 from the defensive skin secretion of the frog, <i>Odorrana livida</i>
… possessed neither significant antimicrobial nor haemolytic activity on horse erythrocytes. Besides, similar negative results were also found in the assessments of anti-cancer activity, trypsin inhibitory activity and smooth muscle-relaxing activity. The biological actions of this peptide thus …
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QUB-1383, a novel bioactive peptide from the defensive skin secretion of the edible frog (Pelophylax kl. esculentus)
… bioassays including antimicrobial assays, haemolytic assays and trypsin inhibitor assays were conducted to ascertain its bioactivities. The synthetic QUB-1383 not only possessed potent antimicrobial activity against C.albicans, S. aureus and E. coli with minimal inhibitory concentrations at …
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The discovery and evaluation of a novel bioactive peptide, QUB-3112, from the defensive skin secretion of Hylarana guentheri
… and was found to possess strong antimicrobial activity, slight anticancer activity and a relatively weak haemolytic activity. <br/>The experiments carried out in this study only involved a narrow and superficial range of bioactivity identifications. To obtain clearer knowledge about this novel …
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