Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"haemolysis activity"”.
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QUB-3170: a novel peptide with antimicrobial activities from the skin secretion of Phyllomedusa tarsius
… Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi, viruses, bacteria, and even tumour cells. On the other hand, antimicrobial peptides are considered as an essential product of amphibian skin secretions, the skin secretion of amphibian is a rich source of …
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Identification and functional study of a novel bioactive peptide QUB-1761 from the venom of the Brazilian yellow scorpion, Tityus serrulatus
… the haemolytic assays, QUB-1761 showed about 30% haemolysis activity at 64 µM and more than 50% at 128 µM. Nonetheless, QUB-1761 has the potential to be used in the design of drugs to treat bacterial infections or cancer if optimised.<br/><br/><i>Thesis embargoed until 31 December 2026</i>.
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Identification and functional study of a bioactive peptide QUB-2413 from the skin secretion of the Red-Eyed Tree Frog, Agalychnis callidryas
… from 10 -6 M to 10 -4 M. With regard to haemolysis assay, QUB-2413 had no more than 10% haemolysis activity at 512 µM. Although the biological activities of QUB-2413 are not ideal, it is still expected to become a safe anti-positive bacteria drugs in the future after its antimicrobial …
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Assessing bioactivity of a peptide from the skin secretion of the central American red-eyed leaf Frog, Agalychnis callidryas
… did not possess broad-spectrum antimicrobial activity against the Gram-positive bacterium, Staphylococcus aureus, the Gram-negative bacterium, Escherichia coli and the yeast, Candida albicans. However, the peptide had activity against PC-3 and H157 human cancer cell lines at a range of …
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The Discovery and Functional Evaluation of a Novel Bioactive Peptide, QUB-3411, from the Frog Skin Secretion of Hylarana guentheri
… indicating selective antiproliferative activity. Besides, QUB-3411 showed relatively low haemolysis activity against horse erythrocytes but the therapeutic window was narrow. The discovery of the novel peptide QUB-3411 is a complementary of peptide research and further studies are needed …
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Identification and functional study of the bioactive peptide QUB-2830 from the skin secretion of the blue-side leaf frog, Agalychnis annae
… QUB-2830 showed significant antimicrobial activity against a Gram-negative bacterium, Escherichia coli (E. coli ATCC CRM8739), a Gram-positive bacterium, Staphylococcus aureus (S. aureus ATCC CRM6538), and a yeast, Candida albicans (C. albicans ATCC CRM10231). For S. aureus, the minimum …
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A novel bioactive peptide from the skin secretion of the Chinese brown frog, Rana chensinensis
… kinds of cancer cell lines, and haemolytic activity assay using horse red blood cells. The resultsobtained from three individual experiments showed that QUB-1463 did not exhibit antimicrobial activity against S. aureus, E. coli and C. albicans even at the highest concentration and the MIC of …
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Assessment of antimicrobial and antiproliferative activities of a bioactive peptide from the skin secretion of white-lined leaf frog
… subject to antimicrobial, antiproliferative and haemolysis tests to ascertain its bioactivities. This peptide was found to exhibit antimicrobial activity against S. aureus, E. coli and C. albicans with MIC values of 2 µM, 2 µM and 64 µM, respectively. Also, this peptide possessed an …
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Functional genomic study and bioinformatic analysis on natural bioactive peptides
… muscle preparations. It also showed vasorelaxant activity on rat tail artery smooth muscle. In addition, the peptide was modified by substituting the penultimate amino acid in the amino terminus from phenylalanine to leucine. Theanalogue completely abolished parental peptide activity, but showed …
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Molecular cloning, structural characterisation and functional study of peptides from amphibian skin secretion
… were tested. In addition, the antimicrobial activity and antibiofilm activity of AMPs were assessed and their haemolysis activity was also tested. Apart from these, the relationship between structure and function of AMPs was determined by means of CD experiments and secondary structure …
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Discovery and bioactivity assessment of a novel peptide from the skin secretion of the Senegal running frog Kassina senegalens
… properties and mechanisms of biological activity, have been discovered and widely reported. In this study, a novel peptide named QUB-1923 was identified from the skin secretion of the Senegal running frog, Kassina senegalensis. The sequence of the mature peptide (FYHLSALIHGIKQRLK) was …