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Showing 1 to 20 of 38 for “"haematopoietic stem cells"”.
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Mobilisation, Isolation and Coculture of Haematopoietic Stem Cells
Since decades, hematopoietic stem cell transplantation (HSCT) has become a well established treatment modality for hematological malignancies and non-malignant disorders. Autologous and allogeneic hematopoietic stem cells (HSCs) mobilized into the peripheral blood (PB) have been used as a preferred …
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Extrinsic regulation of fate choice in mouse haematopoietic stem cells
Extrinsic regulation of fate choice in mouse haematopoietic stem cells The mechanisms regulating stem cell self-renewal, proliferation, and differentiation are still not fully understood. Improving our knowledge of these processes will not only provide greater insight into stem cell biology but …
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Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells
… molecular mechanisms driving disease in mouse haematopoietic stem cells (HSCs), using JAK2 V617F mutant myeloproliferative neoplasms (MPNs) as a model. This study utilises single-cell gene expression and functional assays to identify a subset of JAK2 V617F mutant HSCs that display defective …
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MOLECULAR CHARACTERISATION OF EXPANDED MOUSE HAEMATOPOIETIC STEM CELLS USING A NOVEL IN VITRO REPORTER STRATEGY
Haematopoietic stem cells (HSCs) are responsible for the lifelong maintenance of the blood forming system which produces trillions of blood cells daily. They are able to achieve this because of two defining properties: 1) they can give rise to progeny which eventually form all of the blood cell …
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The Impact of Clinically Relevant Culture on Human Haematopoietic Stem Cells: A Kinetic Analysis at Single Cell Resolution
Haematopoietic stem cell (HSC) ex vivo gene therapy is now successfully used to treat an in-creasing number of monogenic disorders affecting the blood system. The ultimate efficacy of this therapy depends upon successful targeting of long-term haematopoietic stem cells (LT-HSCs), which are …
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Computational analyses of blood cells: somatic evolution and morphology
… process of blood cell production, carried out by haematopoietic stem cells in the bone marrow. Over the human lifespan, it generates quadrillions of cells which participate in essential bodily functions such as immunity (whiteblood cells), oxygen distribution (red blood cells) and blood …
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The Role of Gata3 in Blood Stem Cell Emergence
The first definitive haematopoietic stem cells (HSCs) produced during embryonic development are generated from a specialised subset of endothelial cells known as haemogenic endothelium. Recently, it was reported that Gata3 plays a dual role in the development of sympathetic nervous system and …
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The role of the Dnmt3aR882H mutation in the evolution of clonal haematopoiesis.
… genetic events during the development of haematopoietic malignancies. Individuals with CHIP, in spite of having a normal full blood count are at increased risk of cardiovascular and pulmonary diseases as well as haematological neoplasms. Somatic mutations in DNMT3A are drivers of CHIP, but …
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Regulation of flt3 gene expression in haematopoietic and leukaemic stem cells
… leads to signalling during the commitment of haematopoietic stem cells (HSCs). Constitutive activation of the Flt3/FL pathway is a key factor in enhanced survival and expansion in acute myeloid leukaemia (AML). Although there is extensive knowledge regarding mutations leading to the …
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The expression profile of cytoglobin in human fibrotic lung, and the protective role of cytoglobin in hypoxia and oxidative stress in vitro
… here is evidence of CYGB expression within cells of fibrotic lesions taken from patients with Idiopathic Pulmonary Fibrosis (IPF) and Chronic Obstructive Pulmonary Disease (COPD). CYGB staining was observed in fibroblasts, endothelial cells, type II pneumocytes, type I pneumocytes, …
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Molecular events governing hematopoietic stem cell recruitment in Vivo in murine liver following Ischemia-reperfusion injury
Evidence suggests haematopoietic stem cells (HSCs) can migrate to injured liver and influence tissue repair. However, the molecular adhesive mechanisms governing HSC recruitment to injured hepatic microcirculation are poorly understood. These mechanisms were investigated in vivo following murine …
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Cholinergic signals promote the quiescence of normal or leukaemic stem cells through the activation of the α7-nicotinic receptor in bone marrow mesenchymal stromal cells
The sympathetic nervous system has evolved to respond to stress and activates haematopoietic stem cells (HSCs) using noradrenergic signals. However, the pathways that maintain HSC quiescence and maintenance during proliferative stress are not well understood. This study has investigated the role of …
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Deciphering Leukaemogenic Mechanisms through System-Scale Analysis of Single-Cell RNA Sequencing Data
Haematopoietic stem cells are responsible for producing and sustaining the diverse array of cell types present in the adult blood system. This complex process requires the strict regulation of haematopoietic fate decisions and differentiation trajectories in order to maintain a healthy state. …
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Neuronal regulation of haematopoietic stem cell ageing and age-related blood disorders through the microenvironment
Haematopoietic stem cells (HSCs) give rise to all blood and immune cells in our body. Residing in the bone marrow (BM), HSCs are surrounded by numerous cell types and the associated extracellular matrix, which form a unique microenvironment known as ‘’HSC niche’’. Sympathetic neurons are important …
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Novel insights into megakaryopoiesis, thrombopoiesis and acute coronary thrombosis: transcriptome profiling of the haematopoietic stem cell, megakaryocyte and platelet
… was to investigate the transcriptome of human haematopoietic stem cells (HSCs), megakaryocytes and platelets to gain insights into steady state and accelerated thrombopoiesis that occurs in states of haemostatic demand and in thrombosis by applying these findings to the pathological setting of …
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Role of the cell cycle during human endothelial-to-haematopoietic transition
Haematopoietic stem cells (HSC) are responsible for the maintenance of blood homeostasis and are of fundamental importance for the treatment of a variety of life-threatening diseases. However, their scarce availability constitutes a major obstacle. Thus, understanding their embryonic specification …
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The analysis of Bcr-Abl—Nox signalling in chronic myeloid leukaemia
… characterised by increased proliferation of haematopoietic stem cells. CML results following generation of the chimeric protein Bcr-Abl, a constitutively active tyrosine kinase which induces oncogenesis in part by promoting increased cell survival and proliferation. Since the development of …
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Somatic evolution in human blood and colon
All cancers were once normal cells. They became cancerous through the chance acquisition of particular somatic mutations that gave them a selective advantage over their neighbours. Thus, the mutations that initiate cancer occur in normal cells, and the normal clonal dynamics of the tissue determine …
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