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Showing 1 to 20 of 37 for “"haematopoietic stem cell"”.
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The Effects of Methyltransferase Genes on Human Haematopoietic Stem Cell Function
The highly structured and hierarchical haematopoietic system is defined by the existence of a pool of haematopoietic stem cells (HSCs) at the apex, which possess both multipotent differentiation and self-renewal properties. The HSC pool is heterogenous in terms of self-renewal and differentiation …
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Interactions between the haematopoietic stem cell and the myeloid microenvironment in aplastic anaemia
… abnormalities in the marrow stroma or the stem cell have been postulated. To define the relative contribution of each of the latter, the integrity of the bone marrow from sixteen patients that responded to anti-lymphocyte globulin and high dose methyl prednisolone was compared to normal …
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Immunotolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for multiple sclerosis
… an autoimmune disease of the central nervous system (CNS). Autologous haematopoietic stem cell transplantation (AHSCT) has received increasing attention in recent years as a therapeutic option for treatment refractory MS. AHSCT has been proposed to induce long-term remission by initiating an …
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Neuronal regulation of haematopoietic stem cell ageing and age-related blood disorders through the microenvironment
Haematopoietic stem cells (HSCs) give rise to all blood and immune cells in our body. Residing in the bone marrow (BM), HSCs are surrounded by numerous cell types and the associated extracellular matrix, which form a unique microenvironment known as ‘’HSC niche’’. Sympathetic neurons are important …
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Characterisation of human Haematopoietic Stem Cell differentiation and exit from quiescence at single cell resolution
… by a set of functionally heterogeneous haematopoietic stem cell (HSC) compartments both in mouse and in human. However, how this diversity is regulated at the cellular and molecular level and when HSC multipotency is lost is still not known, in particular in humans. Quiescence is an …
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Functional and Transcriptional Heterogeneity of the Human Haematopoietic Stem Cell Pool at Steady-State and Under Inflammation
… a functionally heterogeneous pool of multipotent haematopoietic stem cells (HSCs), downstream of which lineage-restricted progenitors are generated. The advent of single cell technologies has changed our view of the haematopoiesis to a dynamic continuum. Understanding the early differentiation …
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Identification of Novel Drivers of Haematopoietic Stem Cell Fate Using Low Cell Number Proteomics and Single Cell Profiling
The abrogation and de-regulation of cellular decisions in adult haematopoietic stem cells (HSCs) have been widely recognised as key contributing factors in ageing and disease. In particular, acquired mutations altering HSC self-renewal contribute to the formation of pre-leukaemic disorders, such as …
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Novel insights into megakaryopoiesis, thrombopoiesis and acute coronary thrombosis: transcriptome profiling of the haematopoietic stem cell, megakaryocyte and platelet
… was to investigate the transcriptome of human haematopoietic stem cells (HSCs), megakaryocytes and platelets to gain insights into steady state and accelerated thrombopoiesis that occurs in states of haemostatic demand and in thrombosis by applying these findings to the pathological setting of …
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Role of Lymphocyte Populations Following Allogeneic Haematopoietic Stem Cell Transplantation // Роля на лимфоцитните популации след алогенна трансплантация на хемопоетични стволови клетки
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an established therapeutic approach for a range of malignant and benign haematological disorders. Despite significant advances in the field of transplantation medicine, this method remains associated with a number of complications – …
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"It really kind of like cuts my existence into two": an interpretative phenomenological analysis of the experience of adults with sickle cell disease receiving curative Haematopoietic Stem Cell Transplantation (HSCT)
Background: Sickle cell disease (SCD) is the most common single gene disorder in England. At present, Haematopoietic Stem Cell Transplantation (HSCT) is the only cure, and as of 2020, these have been funded for adults with SCD by the National Health Service (NHS) in England. Rationale: The …
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The Role of Gata3 in Blood Stem Cell Emergence
The first definitive haematopoietic stem cells (HSCs) produced during embryonic development are generated from a specialised subset of endothelial cells known as haemogenic endothelium. Recently, it was reported that Gata3 plays a dual role in the development of sympathetic nervous system and …
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Single-cell Protein-Transcriptome Atlas of Haematopoiesis across the Human Lifespan
The haematopoietic system is responsible for the continuous production of stem and progenitor cells, which divide and mature to produce a wide variety of specialised circulating blood cells. Proper regulation of lineage decisions is key to ensure the right balance between the generation of …
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Cell separation and cryopreservation of cord blood fractions for immunotherapeutic applications
… umbilical cord blood (CB) bank (Anthony Nolan Cell Therapy Centre, ANCTC) in which CB is stored for haematopoietic stem cell (HSC) transplantation. Due to strict quality thresholds, the majority of units are not suitable for transplantation. Therefore, ANCTC aims to create a Biobank allowing …
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Clonal dynamics of haematopoiesis across the human lifespan
The haematopoietic system manifests several age-associated phenotypes including anaemia; loss of regenerative capacity, especially in the face of insults such as infection, chemotherapy or blood loss; and increased risk of clonal haematopoiesis and blood cancers. The cellular alterations that …
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Characterising the MLL complex: epigenetic regulation of Hoxa genes
… to gene regulation in a functionally relevant cell background. To assess dynamic processes involved, we developed a haematopoietic Stem Cell (hSC) -based system, in which Hoxa genes are down-regulated in a differentiation- induced manner. I characterised the histone modification distribution on …
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A genomic investigation into gastrointestinal antimicrobial resistance and clinical infection in patients undergoing transplantation
… recipients – Small Bowel Transplantation and Haematopoietic Stem Cell Transplantation; and 3) illustrate the longitudinal evolution of AMR in these transplant cohorts. Using genomic data, I developed high-throughput screening strategies to aid in the monitoring and mitigation of …
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A comparison of health technology adoption in four countries (Japan, Korea, the UK, and the US)
… reproductive technologies, cochlear implants, haematopoietic stem cell transplantations, caesarean section deliveries, Gamma knife units and kidney transplants in four countries: Japan, Korea, the UK and the US. The interactions between the micro factors of health technologies and the macro …
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Understanding the role of extrinsic regulators in normal and malignant haematopoiesis
… in key molecules can directly modulate haematopoietic stem cell (HSC) fate, implicating noncell intrinsic mechanisms for both maintaining homeostasis and for driving disease development. This thesis spans both normal and malignant haematopoiesis, assessing the impact of extrinsic …
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Immunological evaluation of HIV-negative invasive fungal disease at Groote Schuur Hospital, Cape Town, South Africa
… with another secondary immunodeficiency e.g. haematopoietic stem cell transplant. After excluding secondary immunodeficiency, a detailed immune work-up can lead to a diagnosis of primary immunodeficiency. Objective To detail an appropriate step-wise immunological work-up for a series of …
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Development of a novel approach to expand umbilical cord blood-derived haematopoietic stem/progenitor cells ex vivo for clinical transplantation
… is a well established alternative source of haematopoietic stem/progenitor cells (HSPC) for haematopoietic stem cell transplantation (HSCT). One factor limiting the wider use of UCB for transplantation is the relatively low cell dose from a UCB unit compared to bone marrow (BM) and peripheral …
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