Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"hOgg1"”.
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REPAIR AND EFFECTS OF THE 8-OXOG LESION IN DNA
… investigated. Base excision of 8-oxoG by Fpg and hOGG1 indicated that: i) the position of the lesion 8-oxoG in naked DNA can influence BER activity; ii) nucleosomal formation decreases the activity of these BER enzymes by as much as 2.5 fold with a rotational dependence exhibiting increased …
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REPAIR AND EFFECTS OF THE 8-OXOG LESION IN DNA
… investigated. Base excision of 8-oxoG by Fpg and hOGG1 indicated that: i) the position of the lesion 8-oxoG in naked DNA can influence BER activity; ii) nucleosomal formation decreases the activity of these BER enzymes by as much as 2.5 fold with a rotational dependence exhibiting increased …
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Altered DNA Repair, Antioxidant and Cellular Proliferation Status as Determinants of Susceptibility to Methylmercury Toxicity in Vitro
… fibroblasts (MEFs); and, (2) human Ogg1 (hOgg1)- or formamidopyrimidine glycosylase (Fpg)-expressing human embryonic kidney (HEK) cells; reciprocal in vitro cellular models with deficient and enhanced ability to repair oxidatively damaged DNA respectively. When spontaneously-immortalized …
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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite
… response to changes in glutathione, changes in hOgg1 transcription occur similar to genes regulated by the transcription factor Nrf2. It was determined that positions - 47 to - 44 in the hOgg1 promoter are necessary for basal transcription of Ogg1 determined by site-directed deletion. This …
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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite
… response to changes in glutathione, changes in hOgg1 transcription occur similar to genes regulated by the transcription factor Nrf2. It was determined that positions - 47 to - 44 in the hOgg1 promoter are necessary for basal transcription of Ogg1 determined by site-directed deletion. This …
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More evidence for H2O2-mediated oxidative stress in vitiligo-increased epidermal DNA damage / repair.
… develop effective DNA repair machinery via hOgg1, APE1 and DNA polymeraseß. Taking into consideration that these patients do not have an increased prevalence for solar-induced skin cancers, our data suggest that BER is a major player in the hierarchy to combat H2O2-mediated oxidative stress …
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H2O2-mediated oxidation and nitration enhances DNA binding capacity / DNA repair via up-regulated epidermal wild-type p53 in vitiligo.
… a powerful machinery to mediate DNA repair via hOgg1, APE1 and DNA polymerase ß (Shalbaf 2009). On this basis it is tempting to conclude that DNArepair is the overriding mechanism to combat oxidative stress in this disease.