Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"hMSCs"”.
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Protective effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Apoptosis Induced Human Neuroblastoma SH-SY5Y Cells
… bone marrow-derived mesenchymal stem cells (hMSCs) is an attractive tool to alleviate neurological disease We investigate whether culture media of hMSCs and coculted hMSC using by transwell have effects against apoptosis induced SH-SY5Ys. SH-ST5Ys were treated with 0.25？？M Stausrosporine(STS) …
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Neuroprotective Effect of Human Mesenchymal Stem Cell on Dopaminergic Neurons by Anti-inflammatory Action
… human bone marrow-derived mesenchymal stem cell (hMSCs) on modulation of neuroinflammation. We used lipopolysaccharide (LPS)-induced in vitro and in vivo inflammation models to investigate whether hMSCs have a protective effect on the dopaminergic system through anti-inflammatory mechanism. hMSCs …
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Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… marrow-derived human mesenchymal stem cells (hMSCs) offer a viable alternative to enhance therapeutic delivery – one that overcomes current limitations. hMSCs are a population of cells with the capability of self-renewal and multilineage differentiation that can be safely isolated in routine …
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Control of proliferation in human mesenchymal stem cells by Secreted Frizzled Related Protein 1
… between Wnt signaling and proliferation of hMSCs. When checked mRNA expression of various genes that were related to Wnt signaling, most of genes were decreased gradually as follow passages, except Wnt11. Especially, gene expression of sFRP1, an antagonist of Wnt signaling, was also …
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Neuroprotective effect of mesenchymal stem cells in neurodegenerative disease : focusing on Parkinsonian disease
… studies demonstrating neuroprotective effect of hMSCs in Parkinson’s disease, we extended our investigations into other parkinsonian disease in addition to properties of hMSCs on blood-brain barrier. . PART A. Human mesenchymal stem cells exerts neuroprotection in an animal model of double …
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Mesenchymal Stem Cells Therapy in Progressive Rat Model of Parkinson's Disease
… the effect of human mesenchymal stem cells (hMSCs) therapy in vitro and progressive SD rat model of PD using MG-132, proteasome inhibitor. Immunocytochemical analyses in primary mesencephalic culture revealed that hMSC treatment increased dopaminergic neuronal survival compared to …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… available. Human Mesenchymal Stromal Cells (hMSCs) are a promising candidate therapy which are currently being investigated in clinical trials for ARDS. However their mechanisms of effects in lung injury are not fully elucidated. A fuller understanding of these mechanisms may highlight novel …
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Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
… development, but the role in proliferation of hMSCs is not well known. In this study, we investigated the effect of Wnt signaling molecules on the proliferation of hMSCs. The relative expression of secreted frizzled-related protein 1, an inhibitor for canonical Wnt signaling, was declined with …
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SVILUPPO DI TECNICHE PER L'ISOLAMENTO, LA CARATTERIZZAZIONE E IL DIFFERENZIAMENTO DI CELLULE STAMINALI MESENCHIMALI PER UN USO IN MEDICINA RIGENERATIVA
… prevent any problem of graft rejection. The hMSCs can be found in the bone marrow and the adipose tissue. In this case, they are called Adipose-like stem cells (hASCs), and share common characteristics with the hMSCs as it has already been described in the literature and in my project too: …
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APPLICATION OF POLYETHYLENE-GLYCOL LINKED MULTI-WALLED CARBON NANOTUBES FOR IMPROVED STEM CELL DIFFERENTIATION
… DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS (HMSCS), EVEN IN THE ABSENCE OF MYOGENIC INDUCTION FACTORS. TO ENHANCE THE MYOGENIC DIFFERENTIATION OF HMSCS, WE DESIGNED AND FABRICATED A PEG-CNTS COATED POLY-ACRYLAMIDE HYDROGEL WITH CLOSE STIFFNESS TO HUMAN MUSCLE (CNT-PA-M) AND SPONTANEOUS …
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Proteomic Analysis of Human Mesenchymal Stem Cell Aging during serial sub-culture
"Human mesenchymal stem cells (hMSCs) hold great potential for clinical applications in regenerative medicine. However, hMSCs occur at a very low frequency in bone marrow so the clinical use as cellular therapeutics requires suitable techniques for isolation and expansion. Furthermore, these cells …
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Therapeutic Effects of Human Mesenchymal Stem Cells on Traumatic Brain Injury in Rats: Secretion of Neurotrophic Factors and Inhibition of Apoptosis
… bone marrow-derived mesenchymal stem cells (hMSCs) in the rat model of TBI, we analyzed the neurological functions and in vivo growth factor production. Male Sprague-Dawley rats were injured with a CCI device and divided into two experimental groups: those which received hMSCs intravenously …
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Characterisation of STRO-1 expression on human mesenchymal stem cells and identification of putative cancer stem cells in osteosarcoma: prevention by micronutrients
… culture expanded human mesenchymal stem cells (hMSCs) in regenerative medicine due to their low incidence in vivo. However, their successful application is hampered by a lack of selective markers to positively identify the expanded multipotent cells. This study aimed to characterise STRO-1 …
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Calibration and Validation of an in Vitro Ultrasound Device to Deliver Targeted Thermal Enhancement of hMSC Osteogenesis
… the coupling of the two effects of ultrasound on hMSCs in a preliminary investigation based on our prior work that focused on thermal effects alone. The aim of this thesis is to create and calibrate an ultrasound stimulation device compatible with standard cuboidal ultrasonic transducers for in …
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A MULTISCALE APPROACH TO STEM CELL-BASED CHONDROGENESIS FOR CARTILAGE REPAIR
… soft-lithography. Human mesenchymal stem cells (hMSCs) were selectively seeded in these channels. The chondrogenic potential of hMSCs seeded in these channels was investigated. We demonstrate selective seeding of viable hMSCs within the channels. hMSC aligned and produced mature collagen fibrils …
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The synergistic effect of pulsed electromagnetic fields and demineralized bone matrix on the osteogenic differentiation of mesenchymal stem cells
… the present study human mesenchymal stem cells (hMSCs) were seeded on DBM scaffolds in the presence of PEMF to determine if an increased osteogenic response could be induced. hMSCs were harvested from scaffolds at 5, 7, 14, and 21 days and osteogenic differentiation was assessed by testing for …
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Modulation of mesenchymal stem cell invasion into decellularized engineered tissues
… and ascorbic acid promote the invasion of hMSCs into decellularized engineered tissues. We speculate that this is due to an increase in motility and proliferation of hMSCs when exposed to these factors. Furthermore, hMSC invasion into aligned and non-aligned matrices was not different, …
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Comprehensive Proteomic Analysis and Characterization of Human Bone Marrow Mesenchymal Stem/Stromal Derived Extracellular Vesicles
… by human mesenchymal stromal/stem cells (hMSCs). As the hMSC-EV regenerative capacity is mainly ascribed to the transfer of proteins and RNA composing the EV cargo and to the activity attributed by the protein surface markers, we sought to profile the protein composition of hBM-MSC-EVs …
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Direct-write assembly of 3D microperiodic scaffolds for tissue engineering applications
… are cultured with human mesenchymal stem cells (hMSCs) and support cell adhesion, growth, and chondrogenic differentiation. To produce 3D silk scaffolds at larger length scales for bone tissue engineering, hydroxyapatite (HA) nanoparticles are added to the silk fibroin inks to form a HA-filled …
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Mechanistic and Clinical Studies of Platelet Rich Plasma: A Simple Clinical Method for Enhancing Bone and Soft Tissue Healing
… study utilizing human mesenchymal stem cells (hMSCs) to provide a mechanistic basis for bone formation following PRP use. Enhanced proliferation and inducement of differentiation of hMSCs were found to the possible explanations for the clinical successes reported with PRP use.</p><p> A …
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