Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"hMSC"”.
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Interaktionen von humanen mesenchymalen Stromazellen (hMSC) mit Plattenepithelkarzinomzellen des Oropharynx in indirekter Kokultur
Maligne Tumorzellen interagieren auf vielfältige Weise mit dem benachbarten Tumorstroma mesenchymalen Ursprungs, wodurch grundlegende Eigenschaften hinsichtlich Invasivität und Metastasierungsverhalten gesteuert werden können. So wird z.B. bei hepatozellulären Karzinomen oder bei Zellen der …
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Calibration and Validation of an in Vitro Ultrasound Device to Deliver Targeted Thermal Enhancement of hMSC Osteogenesis
… our prior work, the effects of thermal dosing on hMSC cultures induced to osteogenesis was explored, and it was determined that thermal dosing via heat shocking in an incubator for one hour upregulates alkaline phosphatase (ALP) activity and calcium deposition, indicators of bone formation. In …
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Dreidimensionales epidermis-ähnliches Wachstum humaner mesenchymaler Stammzellen auf dermalen Äquivalenten : Einfluss der experimentellen Kulturbedingungen auf Differenzierung, Migration und funktionelles Verhalten
Human mesenchymal stem cells (hMSC) are able to differentiate into mature cells of various mesenchymal tissues. Recent studies have reported that hMSC may even give rise to cells of ectodermal origin. This indication of plasticity makes hMSC a promising donor source for cell-based therapies. This …
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Proteomic Characterization of Human Multipotent Stromal Cells Secreted Proteins with Therapeutic Potential for β-cell Regeneration
… using human multipotent stromal cells (hMSC). However, the secretory factors responsible for initiating endogenous regeneration remain unknown. Successful large-scale proteomic applications to address these questions have been limited in part by difficulties in correctly selecting the …
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Charakterisierung von humanen mesenchymalen Stammzellen und Zellen der osteoblastären Differenzierungskaskade
… eine eindeutige Identifikation undifferenzierter hMSC noch eine Abgrenzung von hMSC zu anderen Reifungsstufen der osteoblastären Kaskade. Das Ziel dieser Untersuchung war es daher, über die Erstellung eines immunzytochemischen Färbeprofils mehrerer Marker gleichzeitig, undifferenzierte hMSC …
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Analysis of Therapeutic Effect after Human Mesenchymal Stem Cell Transplantation in Ischemic Stroke Rat
… of biochemical and physiological changes of hMSC-treated MCAo rat, I performed proteomic analysis of sham (n=3), tMCAo-only group (n=3) and hMSC-treated tMCAo rat group (n=3). Using 2-dimensinal electrophoresis (2-DE) and matrix-assisted laser desorption/ionization-time of flight-mass …
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Development of methods for the tissue engineering of cardiac valves using mesenchymal stem cells
… biochemicals. The phenotype of the human MSC (hMSC) was then examined by FACS analysis. A previously developed decellularised porcine aortic valve matrix was biochemically characterised to ensure that the major matrix components had not been removed by the decellularisation procedure. …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… available. Human Mesenchymal Stromal Cells (hMSCs) are a promising candidate therapy which are currently being investigated in clinical trials for ARDS. However their mechanisms of effects in lung injury are not fully elucidated. A fuller understanding of these mechanisms may highlight novel …
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Vergleich der Differenzierungspotentiale humaner mesenchymaler Stammzellen aus dem Knochenmark und aus der Nabelschnur auf kollagenen Matrices
… molecular biology via RT-PCR. However, the BM-hMSC showed a stronger osteogenic transformation under two-dimensional culture conditions, whereas the UC-hMSC with contact to the collagenous matrix were superior to extracellular mineralisation and synthesis of extracellular matrix. In addition …
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Mesenchymal Stem Cells Therapy in Progressive Rat Model of Parkinson's Disease
… the effect of human mesenchymal stem cells (hMSCs) therapy in vitro and progressive SD rat model of PD using MG-132, proteasome inhibitor. Immunocytochemical analyses in primary mesencephalic culture revealed that hMSC treatment increased dopaminergic neuronal survival compared to …
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Elucidating Cause-Effect Relationships between Extracellular Matrix Signaling and Mesenchymal Stem Cell Differentiation
… of integrin ?1 and ?2 binding on human MSC (hMSC) osteogenesis was investigated toward the goal of deconvoluting the impact of integrin-based interactions on associated cell behavior. In terms of the osteoinductivity of select ECM components, the results showed that both FG and LN enhanced …
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Proteomic Analysis of Human Mesenchymal Stem Cell Aging during serial sub-culture
"Human mesenchymal stem cells (hMSCs) hold great potential for clinical applications in regenerative medicine. However, hMSCs occur at a very low frequency in bone marrow so the clinical use as cellular therapeutics requires suitable techniques for isolation and expansion. Furthermore, these cells …
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Untersuchungen zur Bedeutung mesenchymaler Stammzellen in der Geweberegeneration
Mesenchymal stem cells (hMSC) are suitable for applications in tissue regeneration and tissue engineering. The combination of mesenchymal stem cells with biomaterials requires extensive knowledge about biological (concerning the cells) and technical (concerning the biomaterial) basics. New …
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Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
… bone marrow-derived multipotent stromal cells (hMSC) generated conditioned media (CM) that promoted β-cell regeneration in streptozotocin-treated mice. Ductal-derived endocrine progenitors, which have been shown to generate β-cells following pancreatic injury, represent a candidate for the …
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Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
Human mesenchymal stem cell (hMSC) is an attractive source of adult stem cells for the therapeutic use in regenerative medicine. These cells are usually culture expanded prior to their application. However, their proliferation and differentiation potential were gradually decreased during in vitro …
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Neuroprotective effect of mesenchymal stem cells in neurodegenerative disease : focusing on Parkinsonian disease
… studies demonstrating neuroprotective effect of hMSCs in Parkinson’s disease, we extended our investigations into other parkinsonian disease in addition to properties of hMSCs on blood-brain barrier. . PART A. Human mesenchymal stem cells exerts neuroprotection in an animal model of double …
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Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… marrow-derived human mesenchymal stem cells (hMSCs) offer a viable alternative to enhance therapeutic delivery – one that overcomes current limitations. hMSCs are a population of cells with the capability of self-renewal and multilineage differentiation that can be safely isolated in routine …
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Control of proliferation in human mesenchymal stem cells by Secreted Frizzled Related Protein 1
Human mesenchymal stem cell (hMSC) is adult stem cell that is useful tool for a various disease. However, it has limitations that lost proliferation and differentiation ability in long-term in vitro culture and occurred senescence. This study would like to confirm the relationship between Wnt …
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Comprehensive Proteomic Analysis and Characterization of Human Bone Marrow Mesenchymal Stem/Stromal Derived Extracellular Vesicles
… by human mesenchymal stromal/stem cells (hMSCs). As the hMSC-EV regenerative capacity is mainly ascribed to the transfer of proteins and RNA composing the EV cargo and to the activity attributed by the protein surface markers, we sought to profile the protein composition of hBM-MSC-EVs …
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Protective effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Apoptosis Induced Human Neuroblastoma SH-SY5Y Cells
… bone marrow-derived mesenchymal stem cells (hMSCs) is an attractive tool to alleviate neurological disease We investigate whether culture media of hMSCs and coculted hMSC using by transwell have effects against apoptosis induced SH-SY5Ys. SH-ST5Ys were treated with 0.25??M Stausrosporine(STS) …
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