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Showing 1 to 12 of 12 for “"hIAPP"”.
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Insulin based inhibitors of human islet amyloid polypeptide (hIAPP) and their effect on hIAPP- mediated membrane damage in type 2 diabetes mellitus
… 2 diabetes. Insulin has been found to inhibit hIAPP (Human Islet Amyloid Polypeptide) aggregation. The HLVEALYLVC amino acid region of insulin contacts hIAPP near the N-terminus. Truncated and modified analogs of insulin containing the binding region (VEALYLV, VEALFLV and EALYLV) were …
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Insulin based inhibitors of human islet amyloid polypeptide (hIAPP) and their effect on aggregation of hIAPP in the treatment of type II diabetes
<p>Human islet amyloid polypeptide protein (hIAPP) is secreted by the pancreas along with insulin and is assumed to play a role in pathological development of type II diabetes. It has 37 amino acids in its sequence. Amyloid is formed due to misfolding of the protein, which is cytotoxic to beta …
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Role of aromatic pi-stacking on the aggregation of human islet amyloid polypeptide (hIAPP)
<p>Human islet amyloid polypeptide (hIAPP) is secreted in the β-cells of the pancreas, which also secretes insulin. In type 2 diabetes mellitus, hIAPP undergoes self-aggregation, forming fibrils. This self-aggregation is cytotoxic and is thought to be linked to type 2 diabetes mellitus by causing …
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Insulin based analogs HLVEALYLV and LVEALYLV to inhibit the formation of amyloid fibrils in beta cells
<p>Human islet amyloid polypetide (hIAPP) is a 37 amino acid peptide, co-secreted along with insulin in the islets of Langerhans of pancreatic beta cells. Aggregation of hIAPP fibrils is believed to be toxic to beta cells and responsible for beta cell dysfunction and death associated with type 2 …
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Experimental simulation of human islet amyloid polypeptide (hIAPP)-pancreatic beta cell membrane interactions: Inferences and implications in the etiopathogenesis of diabetes mellitus type II
… likely by human islet amyloid polypeptide (hIAPP) that is co-secreted with insulin. Increasing health care costs, coupled with the World Health Organization’s prediction of a worldwide diabetic epidemic by year 2030, make experimental diabetes research a crucial prologue to future clinical …
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Membrane fragmentation by a 20-29 fragment of human islet amyloid polypeptide and rat amyloid polypeptide
… amyloidogenic human Islet Amyloid Polypeptide (hIAPP, also known as human amylin) is believed to play a crucial role in this biological process. Previous studies have shown that hIAPP forms small aggregates that kill β-cells by disrupting the cellular membrane. In this study we report membrane …
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Synthesis and dye leakage assay of human and rat islet amyloid polypeptide 10-19 and insulin 14-18
… During type 2 diabetes mellitus, human IAPP (hIAPP) fibrilizes to form amyloid deposits that are found post-mortem in more than 95% of people with the disease. Rodents do not suffer from type 2 diabetes mellitus as their IAPP (rIAPP) does not undergo self-aggregation. Although the amyloid …
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Unzipping Amyloid Fibrils: How a Novel Calcium-Binding Protein, NUCB1, Prevents the Formation of Amyloid Fibrils
… amyloidogenic human Islet Amyloid PolyPeptide (hIAPP) and Amyloid-β 42 (Aβ42) peptides, as relevant to Type-2 Diabetes and Alzheimer's disease. In addition, we also show that Ca<sup>2+</sup>-free sNUCB1 can effectively dissociate amyloid fibrils formed by both hIAPP and Aβ42. Interestingly, …
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Fluorescence fluctuation spectroscopy and microscopy : application to cellular molecular dynamics and organization
… to imaging FCS data in order to resolve hIAPP-induced microdomain spatial organization and temporal dynamics in the cell membrane. Our analysis resolved the temporal evolution of multiple diffusing species in the spatially heterogeneous cell membrane, lending support to the "carpet model" …
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Linking Environmental Toxicant Exposure To Diabetes Susceptibility
… and increased β-cell compensation. And in hIAPP transgenic mice we demonstrated that Pb exposure, in combination with a high fat diet, caused the development of fasting hyperglycemia and glucose intolerance as well as Pb-induced islet hyperplasia and striking pancreatic amyloid plaque …
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Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes
Human islet amyloid polypeptide (hIAPP), also known as amylin, is the main constituent of the amyloid deposits present in approximately 95% of people with type 2 diabetes. Amylin aggregates into oligo-/polymeric sheet structures which are considered to be cytotoxic to pancreatic -cells. Inhibiting …
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USING B-STRAND AND B-HAIRPIN PEPTIDOMIMETICS INDUCED BY CONSTRAINED AMINO ACIDS TO MODULATE THE AGGREGATION OF THE MICROTUBULE ASSOCIATED PROTEIN TAU: DESIGN, SYNTHESIS AND EVALUATION
… show no activity on the other amyloid protein hIAPP. These compounds were designed either on Tau PPIs, by mimicking its self-interaction in NFTs or its physiological interaction with MTs; or on small sequences of the chaperone protein Hsp90, which is a physiological Tau aggregation inhibitor: …