Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 284 for “"gut microbiota"”.
-
The gut microbiota in depression
The accruing data linking the gut microbiota to the development and function of the central nervous system has been proposed as a paradigm shift in neuroscience. Neuroimmune, neuroendocrine and neural communication pathways exist between host and microbe. These pathways are components of the …
-
Towards engineering the gut microbiota
… organisms in successional states in the human gut, and identify host- and diet-derived metabolites as environmental signals mediating the growth and colonization of these organisms. In the second study, I examined the potential for using targeted manipulations of diet to favor selective growth …
-
Examining the gut microbiota in aging
The human gut microbiome, comprised primarily of bacteria, plays a crucial role in overall health and physiology by regulating metabolism, immunity, and behavior through the microbiota-gut-brain axis (MGBA). Key functions include fermenting complex carbohydrates into short-chain fatty acids (SCFAs) …
-
Antibiotic resistance in the gut microbiota
… understanding the effects of antibiotics on the gut microbiota, as well as the potential for such populations to act as a reservoir for resistance genes, is imperative. This thesis set out to investigate the gut microbiota of antibiotic treated infants compared to untreated controls using …
-
Cystic fibrosis and the gut microbiota
The role of the gut microbiota in host health has been established in recent years and has been shown to be altered in numerous disease states, including Cystic Fibrosis (CF) cohorts. This thesis investigates the gut microbiota and microbiome in CF persons and how it may be manipulated through …
-
CNS Remyelination and the Gut Microbiota
… of the immune system depend on signals from the microbiota, and we know that a well-coordinated immune response is a key determinant of the success of remyelination. This thesis explores how the microbiome can influence CNS remyelination. To do so, I have studied remyelination in three murine …
-
Gut Microbiota Regulation of SLE Pathogenesis
… the intricate connection between SLE and the gut microbiota. A literature review offered a comprehensive analysis of current research, with a particular emphasis on potential interactions between bacterial flagellin and Toll-Like Receptor 5 (TLR5) on immune cells. These interactions garnered …
-
Understanding the development of gut microbiota and effect of Salmonella Typhimurium infection on gut microbiota in layers
In the last two decades, the focus on chicken gut microbiota has increased exponentially due to its critical role in digestion, nutrient absorption, modulation of immunity, and protection against enteric pathogens. Thus, understanding its role in food-producing animals like chickens is essential …
-
Gut Microbiota of Migratory Passerines at Stopover
<p>Although the gut microbiota provides many beneficial functions to animal hosts, relatively little is known about the gut microbiota of passerines. It is likely that gut microbes are especially important during the migratory phase; however gut atrophy experienced during prolonged migratory flight …
-
The gut microbiota in immune-mediated disorders
The human gut microbiota is a diverse community of microbes residing in the intestine. Evidence from various animal models and human studies have highlighted its potential role in health, metabolic and immune-associated conditions such as osteoporosis, inflammatory arthritis, inflammatory bowel …
-
Establishment and development of infant gut microbiota
The nascent gut microbiota at birth is established in concert with numerous developmental parameters. Here, in the INFAMTET study, we chronicled the impact of some factors which are key determinants of the infant gut microbiota, namely; mode of birth, gestational age, and type of feeding. We …
-
Habitual gardening and the human gut microbiota
The student, Marina Brown, submitted this Thesis for approval on 2021-07-20 at 14:08.
-
Effects of Brassica on the human gut microbiota
… humans. Glucosinolates are metabolised in the gut by members of the gut microbiota, producing biologically active breakdown products, such as isothiocyanates. The effects of consuming Brassica on the composition of the gut microbiota, and the bacterial mechanisms employed for glucosinolate …
-
Probiotic Supplementation, The Gut Microbiota, and Cardiovascular Health
… of death in the United States. Recently, the gut microbiota has been implicated in the pathophysiology and progression of CVD. Experimental evidence suggests that high fat feeding alters the functional composition of the gut microbiota (dysbiosis); leading to increased translocation of the …
-
Aromatic Amino Acid Metabolome In The Human Gut Microbiota
… common substrates are key candidates for host-microbiota crosstalk due to the potential for convergent biosynthetic pathways. Several human signaling molecules are simple structures derived from aromatic amino acids (phenylalanine, tryptophan, and tyrosine). In this thesis, I employed targeted …
-
The bi-directional relationship between gut microbiota and autoimmunity
… serve as a major reservoir for a vast number of microbiota. These microbes have evolved symbiotic relationships with humans due to their close proximity with their host. As a result, the immune system adapts to the microbiota thus modulating immunological function. Autoimmunity is a state in …
-
Influence of gut microbiota on immune system in infants
Background and Methods: Microbiota play many significant, direct or indirect, beneficial and detrimental roles in humans. Microbiome development is established at infancy where diet plays a directive role in the proliferation of gut microbes. It has been shown that the presence of a defined set of …
-
The role of gut microbiota in systemic lupus erythematosus
… have been implicated in the disease mechanisms. Gut microbiota as an environmental factor and the immune system interact to maintain tissue homeostasis, but whether this interaction is involved in the pathogenesis of SLE is unclear. In a classical model of lupus nephritis, MRL/lpr, we found …
-
Nutritional aspects and gut microbiota in paediatric inflammatory bowel disease
… for a mechanism of action mediated through gut rest, and protein/energy reconstitution have not been established. On the other hand the strong evidence for the role of the indigenous microbiota and micronutrients in disease aetiology and mucosal injury, challenged the researcher to explore …
Page 1 of 15