Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"gut microbes"”.
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Gut microbes and brain function
The gut-brain-microbiota axis comprises an extensive communication network between the brain, the gut, and the microbiota residing there. If the composition or the diversity of the gut microbiota is impaired, this can have negative consequences for host health and has been associated with disorders …
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Signatures of gut microbes in human diseases
The human body constitutes a complex ecosystem inhabited by a vast and diverse community of microorganisms. Through evolution, host-microbe interactions have been shaped toward mutually beneficial relationships that support host health. Consequently, perturbations of the microbial compartment are …
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Gut microbes and serum metabolomics in canine with diabetes mellitus
… transplantation (FMT) may help improve gut function and glycemic control of diabetic dogs. The results presented herein are part of a larger prospective randomized, place-controlled, double blinded clinical study that evaluated the effects of FMT on diabetic dogs compared to placebo …
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Identification and characterization of thiamine biosynthesis, transport, and regulation elements among bacteroides species
… adverse neurological effects. However, the role gut microbes play in modulating thiamine availability is poorly understood. In addition, little is known about how thiamine, the Bacteroidetes ability to biosynthesize and transport thiamine, or the regulation of biosynthesis and transport impacts …
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Investigating the host-microbe dialogue in aging
This thesis aimed to investigate the role of the gut microbiota and their associated functionality in the context of aging and life stage related diseases. The focus was maintained on key inter-kingdom signalling molecules, host produced but bacterially modified Bile acids (BAs) and on dietary …
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Microbial glucosinolate metabolism: Characterization of Enterococcus faecalis XL1 and functional analysis of a GH4 enzyme
… plant myrosinases are inactivated by cooking, gut microbes become the primary contributors to ITC formation. However, the microbial enzymes and pathways responsible for GSL metabolism remain poorly understood. This dissertation investigates the bacterial mechanisms underlying GSL hydrolysis, …
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Gut Microbiota of Migratory Passerines at Stopover
<p>Although the gut microbiota provides many beneficial functions to animal hosts, relatively little is known about the gut microbiota of passerines. It is likely that gut microbes are especially important during the migratory phase; however gut atrophy experienced during prolonged migratory flight …
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Investigating the longitudinal dynamics of the human gut microbiome and immune system
… of two human-associated biological systems: the gut microbiome and the adaptive immune system. These two systems are closely intertwined, and engage in significant crosstalk with each other and with the rest of the body. Advances in recent years in high-throughput sequencing technologies have …
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Gut-associated microbial symbionts of the marsh fiddler crab, Uca pugnax
… the ecology and genetic diversity of resident gut microbes to advance our understanding of their interactions with their host, the marsh fiddler crab, Uca pugnax. Furthermore, we assessed whether microbes benefit the host by contributing extracellular enzymes along the digestive tract. This is …
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Variability in fecal microbial drug deglucuronidation
The gut microbiota is a diverse community of various microorganisms that are responsible of numerous essential functions within the human body, including the biotransformation of endogenous compounds and xenobiotics, such as drugs. Several intestinal bacteria produce various β-glucuronidase …
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THE EVOLUTIONARY ECOLOGY OF HOST-MICROBIOME SYMBIOSIS IN ONTHOPHAGUS DUNG BEETLES
… pass to their offspring a conserved group of gut microbes, and that these vertically inherited microbes enhance offspring growth, development, and survival, especially under stress. In the first three chapters of my dissertation, I employed a manipulative method which allowed for the exchange …
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Harnessing the bacteriocin-producing capacity of the gut with a view to controlling microorganisms that have been associated with obesity and related metabolic disorders
… of serious implications for human health. The gut microbiota in obesity and related metabolic conditions has received considerable attention. The aim of this project was to (1) harness the bacteriocin-producing capacity of the gut and (2) develop a bacteriocin-producing probiotic that can …
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Application of bacterial ligninase enzymes from rynchophorus ferrugineus’s gut consortium in agropulp biodelignification
… bacteria isolated within the gut of wood feeding insect, Rynchophorus ferrugineus. In this study, four bacterial species capable of depolymerising lignin were isolated, identified and characterised as Klebsiella pneumoniae, Pseudomonas citronellolis, Enterobacter oryzae, and …
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A seasonal comparison of the gut microbiome of the Southern Lesser Galago Galago moholi (A.Smith 1836)
… chances of sharing harmful pathogens. The gut microbiome has been shown to contribute substantially to the health of its host. The composition of gut microbes is strongly affected by the diet of the host. The diet of the Southern Lesser Galago (Galago moholi) shows vast changes throughout …
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The gut microbiome of the wild great tit (Parus major): drivers and fitness consequences
The gut microbiome plays a vital role in its host’s ecology. Clinical studies have shown gut microbes increase host health and fitness by providing digestive and immune functions, as well as aiding development. Natural variation in the microbiome is widely believed to affect host fitness in the …
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The Metabolic Fate of Glucoraphanin in F344 Rats
… consume cooked broccoli they are dependent on gut microbes to hydrolyze GP to reap the health beneficial effects of SF. Relatively little is known about the hydrolysis products formed as results of bacterial action on GP and the factors that affect the conversion of GP to bioactive sulforaphane …
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Synthesis and translation of novel gram-negative antibacterial agents
… clinical pathogens while sparing healthy gut microbes. The phenyl-thiazolylurea-sulfonamides were largely unsuccessful in achieving wild-type gram-negative activity; however, they largely accumulate to a higher extent, reinforcing the predictive power of the permeation guidelines. Dozens …
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Analysis of the ammonium assimilation pathways of the human colonic bacterium, bacteroides thetaiotaomicron
… thetaiotaomicron, a model organism for human gut Bacteroidetes, encodes genes for the capture of ammonium through the two primary pathways, the glutamate dehydrogenase (GDH) pathway and the glutamine synthetase/glutamate synthase (GS/GOGAT) pathway. To gain insight into the genomic features …
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Characterization of Human Gut Microbiota Dynamics Using Model Communities in Gnotobiotic Mice
<p>The human gut is colonized by a diverse array of microbes, collectively referred to as the microbiota. The microbiota's complexity poses significant challenges in characterizing the rules dictating its assembly, inferring the functional roles of its component species, and understanding how …
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