Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"gut hormone"”.
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Generation and use of new tools for the characterisation of gut hormone receptors
Enteroendocrine hormones released from the intestine following food intake have several roles in the control of metabolism, some of which are exploited therapeutically for the treatment of type 2 diabetes. Within this thesis, focus has been on the receptors of the gut hormones glucagon-like …
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The metabolic sequelae of oesophago-gastric resection
… symptoms. By profiling and challenging the gut hormone axis in healthy volunteers and patients who had undergone total or subtotal gastrectomy, or oesophagectomy, this thesis explores the possible causative mechanisms for the challenges faced by this patient population. In the surgical …
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Quantitation of enteroendocrine hormones as metabolic disease biomarkers in human biological matrices by liquid chromatography tandem mass spectrometry
… both for disease and system regulation. Many gut hormone peptides are secreted by enteroendocrine cells (EECs) and some, known as incretins, are released after a meal to control blood glucose and stimulate neuronal satiety. These are being studied as novel targets for treatment of metabolic …
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Neuroepithelial Signalling in the Colon
… that non-neuronal cells such as those of the gut mucosa may also contribute to TRPV4-mediated nociceptor stimulation. Several gut hormone receptors are also expressed including cholecystokinin (CCK) which is associated with a worsening of postprandial abdominal pain and visceral …
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Characterisation of human enteroendocrine cells in organoid models
Gut hormones secreted by enteroendocrine cells (EECs) coordinate the postprandial response to a meal by regulating digestion, absorption, circulating nutrient availability and satiety. EECs are specialised endocrine cells scattered throughout the gastrointestinal epithelium that release hormones in …
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Effect of progesterone on secretagogue-evoked secretory responses in the isolated pancreas
… of the neurotransmitter acetylcholine (ACh), the gut hormone, cholecystokinin-octapeptide (CCK-8) and the steroid hormone, progesterone on amylase release and preliminary data on ion (potassium (K), sodium (Nat), magnesium (Mg 2+) and calcium (Ca 2+) transport in the isolated pancreas of both male …
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Interactions of islet hormones with acetylcholine and cholecystokinin-octapeptide in the isolated pancreas of normal and diabetic rats
… polypeptide (VIP) and galanin, the islet hormones insulin, glucagon and somatostatin, the neurotransmitter acetyicholine (ACh), the gut hormone cholecystokinin octapeptide (CCK-8), sodium nitroprusside (SNIP), 8-Bromo guanosine 3'5' cyclic monophosphate (8-Br cOMP) and nerve stimulation on …
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Self-assembled peptide as a long-acting drug formulation
… with worldwide rising prevalence [1]. The gut hormone Oxyntomodulin induces satiety and normalizes hyperglycaemia without risk of hypoglycaemic excursions [2]. However, native incretin hormones are quickly degraded by peptidases and renally excreted, which has so far impaired pharmaceutical …
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Neurobiological and metabolic mechanisms of binge-eating in anorexia and bulimia nervosa
… the impact of acute, psychological stress on gut hormones, endocrine responses, and inhibitory control in women acutely ill with the binge-eating and purging subtype of anorexia nervosa, bulimia nervosa and matched controls. Chapters 3 through 5 report the results of this study. Chapter 3 …
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Optimising the management of new-onset prediabetes/diabetes after acute pancreatitis
… part includes studies that investigated the gut hormone profile after a mixed-meal test to identify a distinguishing biomarker for NOPAP/NODAP (comparator groups - type 2 prediabetes/diabetes and health), and the factors associated with that biomarker. The second part includes studies that …
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A peptidomic investigation into enteroendocrine cells and islets of humans and mice
… of the blood and responding by secreting peptide hormones to control various physiological functions. This thesis focuses on characterising the peptidome of EECs and islets by utilising liquid-chromatography coupled to mass spectrometry (LC-MS). Due to their ability to control food intake and …
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The effects of metformin on the gastrointestinal tract
… intestinal cells. GDF-15 is a stress activated hormone that acts on its cognate receptor GFRAL expressed almost exclusively in the brainstem to elicit an inhibition of food intake. GDF-15 was one of the serum biomarkers identified in T2DM patients associated with metformin use. In a …
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Mechanisms underlying monosaccharide stimulated incretin hormone secretion from the intestine
… prevalence worldwide. Drugs which mimic the gut hormone glucagon-like peptide-1 (GLP-1), e.g. Semaglutide, are currently the most effective obesity and T2D therapeutics, activating GLP-1 receptors in the pancreas and brain to improve blood glucose and appetite control. Due to the therapeutic …
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Mechanism of exocrine pancreatic insufficiency during diabetes mellitus
… to investigate the interaction of the islet hormone insulin with the cholinergic neurotransmitter acetylcholine (ACh) and the gut hormone cholecystokinin-octapeptide (CCK-8), measuring the amylase output, intracellular free calcium concentration ([Ca2i), intracellular free magnesium …
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Study of Receptor Binding and Growth Effect of Gastrin Gene Products
… development. Gastrin, a heptadecapeptide, is a gut hormone produced by the G cells in the gastric antrum and functions primarily in stimulating acid secretion from the parietal cells. Besides its role as an acid secretagogue in the stomach, gastrin has also been reported to act as growth factor …
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
The gut is the largest endocrine organ in our body thanks to the presence of hormone-releasing enteroendocrine cells (EECs), which represent only around 1% of the total gut epithelium. Gut hormones are released in response to cues of different natures to regulate several physiological events, such …
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Aib(2)oxyntomodulin Peptide Molecular Self-Assembly: Smart Nanostructures Toward Long Acting Formulation for Obesity and Diabetes Type 2
… Previous studies have revealed that dual agonist gut hormone, oxyntomodulin (Oxm), has a promising beneficial role to treat obesity and T2DM through suppressing the food intake, raising the energy expenditure, and increasing insulin secretion to maintain the normal blood glucose level in the body. …
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A novel nutritional approach to the management of type 2 diabetes: effects of nutritional preloads on postprandial blood glucose and gastric emptying in type 2 diabetes mellitus
… intestine, mediated in part by the secretion of gut hormones. Gastric emptying is often disordered in people with type 2 diabetes; the emptying of solids and/or nutrient liquids is abnormally delayed in up to 30-50% with patients with longstanding type 2 diabetes, while gastric emptying may be …
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Physiological studies of whey protein in older people, with a focus on feeding behaviour, nutrition, obesity, type 2 diabetes mellitus and post-prandial blood pressure
… outcomes assessed were appetite; food intake; gut hormone release; gastric emptying rate; circulating glucose, glucagon and insulin concentrations; BP and heart rate (HR). Chapter 1: Introduction focusses on rising burden of ageing in Australia and other developed countries; nutritional …