Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"guanosine"”.
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Guanosine 5'-diphosphate 3'-diphosphate (ppGpp), guanosine 5'-diphosphate 3'-monophosphate (ppGp) and antibiotic production in Streptomyces clavuligerus
… batch culture. Low levels of intracellular guanosine 5'-diphosphate 3'-diphosphate (ppGpp) were detected at D= 0.02 h' in continuous culture in all media. Low levels of intracellular guanosine 5 '-diphosphate 3 '-monophosphate (ppGp) were detected at D=0.02 if' in carbon- and nitrogen- …
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Synthetic Ion Channels From Lipophilic Guanosine Derivatives
… molecular devices. In this thesis, lipophilic guanosine derivatives that combine both "molecular recognition" and "membrane soluble" features are utilized for the development of the self-assembled synthetic ion channels. The potential of lipophilic G-quadruplexes to function as synthetic ion …
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Benzobisoxazole Cruciforms and Guanosine Derivatives: Syntheses, Structural Analyses, and Optical Properties
… the unsaturated center, and the other is that of guanosine derivatives. Chapter One. This chapter summarizes the previous work on molecular cruciforms: tetrakis(arylethynyl)benzenes, distyrylbis(arylethynyl)benzenes, tetrakis(aryl-vinyl)benzenes, and tetraethynylethenes. Chapter Two. The …
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Guanosine tetra and pentaphosphate metabolism in a slo mutant of Escherichia coli
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Nitrosative guanosine deamination : pyrimidine ring opening implications of effects in homogeneous solution as well as anisotropic environments
… dissertation mainly focuses on the mechanism of guanosine deamination in homogenous as well as ss-DNA and anisotropic environment of ds-DNA by [superscript 17]O- and [superscript 18]O-labeling studies. On the basis of chemistry of primary amine, it was believed that guanosine deamination involves …
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OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION
Oxidation of the guanosine (G) moiety, yielding the oxidized lesion 8-hydroxy-2'-deoxyguanosine (oxo82dG), in DNA has become a hallmark biomarker in assessing cellular outcomes induced by oxidative stress. It is well established that the guanosine nucleotide triphosphate pool is also susceptible to …
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OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION
Oxidation of the guanosine (G) moiety, yielding the oxidized lesion 8-hydroxy-2'-deoxyguanosine (oxo82dG), in DNA has become a hallmark biomarker in assessing cellular outcomes induced by oxidative stress. It is well established that the guanosine nucleotide triphosphate pool is also susceptible to …
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Immunohistochemistry for studying cyclic nucleotides in the central nervous system, with particular reference to guanosine 3',5'-monophosphate
An immunofluorescent technique has been developed with the aim of histochemically localizing cyclic AMP and cyclic GMP in the C.N.S., and determining the cellular sites where biochemical changes in tissue levels occur. Initial experiments revealed that the inmunoglobulin fraction of non -immune …
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The Possible Roles of Cyclic Guanosine 3',5'-Monophosphate in Controlling of The Permeability of The Vertebrate Photoreceptor
Made available in DSpace on 2014-12-14T05:40:46Z (GMT). No. of bitstreams: 1 8009073.pdf: 3823370 bytes, checksum: a8e6d6b6ddd7c699e837ef59d1ebac86 (MD5) Previous issue date: 1979
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Synthesis and Complexation Studies of Heterocyclic Compounds With Two or Three Contiguous Hydrogen Bonding Sites
… to mimic the hydrogen bond functionality of guanosine. A guanosine receptor was developed to ascertain the negative steric interactions inherent in Hamilton's guanosine receptor.
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Fluorescent Modifications of Transfer Ribonucleic Acids
… of RNA molecules. 1,N('2)-(2-Methylallylidene)guanosine ((mu)-guanosine) is the product of MMDA and guanosine. This compound has been characterized by ultraviolet, fluorescence, and nuclear magnetic resonance spectroscopy. We have shown that reaction of MMDA with E. coli tRNA('Phe) occurs and …
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IDENTIFICATION OF HCMV UL97 IN GBM CELL LINES AND A POSSIBLE ROLE FOR GANCICLOVIR
… that has the ability to phosphorylate guanosine analogues, creating a guanosine triphosphate that inhibits DNA elongation and replication. Ganciclovir, a guanosine analogue, was used to treat GBM cell lines and our results demonstrate that it significantly decreases cellular …
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Direct bromine-80 or bromine-82 labelling of biomolecules via excitation labelling methods: preparation of radiopharmaceuticals
… molecules, such as deoxyuridine, L-tyrosine, guanosine, deoxycytodine, phenylalanine and acetic acid, to gaseous CF₃<sup>82m</sup>Br (or CF₃<sup>80m</sup>Br) was studied. The radiochemical yields of the brominated products are relatively small and range from 1% in the case of …
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Supramolecular hybrid organic-inorganic multicomponent architectures in solution and on surface
… materials built through the selfassembly of guanosine, in the absence or in the presence of a cation, in solution and on the surface. By appropriate manipulation of intermolecular non-covalent interactions the spatial (structural) and temporal (dynamic) features of these supramolecular …
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Development of chemical probes for intracellular nucleotide delivery, profiling of the metabolic fate(s) of nucleoside monoester phosphoramidates, and a nucleotide mimetic inhibitor of eIF4E
… intracellular delivery of 7-Chlorophenoxyethyl guanosine monophosphate, as a chemical tool for translational control of protein synthesis. Furthermore, in Chapter 3 we provide another proof-of-concept application of the new pronucleotide strategy for intracellular delivery of 2´-C-β-Methyl …
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Studies relating to fecapentaene-12
… the various putative polyenal metabolites and guanosine, cytosine, or thymidine. A model epoxy ether did react with a guanosine derivative, however, indicating that an epoxy ether derivative of FP-12, if formed, would be capable of reacting with DNA.
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Cell cycle-dependent regulation of the human RNA cap methyltransferase (RNMT)
<br/>The N-7 methylguanosine cap structure is conserved from yeast to man. It is essential for cell proliferation as it influences several steps in eukaryotic gene expression including transcription, pre-mRNA processing, RNA export and translation. The N-7 methylguanosine cap is added …
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Studies on the mechanism of action of thyroid hormones
… nucleotides, adenosine monophosphate (AMP) and guanosine monophosphate (GMP)e through DEAE-Scphacex, and the reaction IMP~ XMP is catalyzed by: IMP dehydrogenase which was purified in a manner similar to adenylosuccinate synthetase. Adenylosuccinate synthetase of rat liver is stimulated …
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Interaction of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase with group I intron RNAs
… the binding site for the splicing co-factor guanosine. My results show that CYT-18 can suppress numerous mutations that impair the self-splicing of the td intron, including mutations that disrupt base-pairing within the P7 region. CYT-18 suppressed mutations of phylogenetically conserved …
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