Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"guanine adducts"”.
-
Homology-Directed Repair of Dna Lesions Generated by the Mismatch Repair Dependent Processing of Cytotoxic Guanine Adducts
… dacarbazine, and temozolomide generate O6-MeG adducts, while a thiopurine antimetabolite 6-thioguanine (6-thioG) generates S6-MeG DNA adducts. Instead of pairing with cytosine, these modified guanines mispair with thymine during DNA replication. The Mismatch repair (MMR) pathway rectifies base …