Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"growth suppression"”.
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Growth Suppression in Simulated Compressible Turbulent Mixing Layers
Direct numerical simulations of turbulent flows require numerical schemes with high resolution and grid flexibility. Resolution properties of B-spline and compact finite-difference schemes are evaluated using Fourier analysis in periodic domains, and tests based on solution of the wave and heat …
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Androgen receptor-mediated growth suppression and apoptosis of human prostate epithelial cells
… (AR) signaling is crucial to the development, growth, and homeostasis of the prostate gland, and its dysregulation mediates common prostate pathologies, including benign and malignant forms of neoplasia. Prostate cancer is the second most prevalent cancer and the sixth leading cause of cancer …
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The molecular basis for tumor growth suppression by tRNA methyltransferase 9-like (TRM9L)
… has an important function in suppressing tumor growth in colorectal cancer. Loss of heterozygosity events on the Chromosome 8p22 loci, where TRM9L is located, are overrepresented in a wide variety of cancers, including prostate cancer, breast carcinoma, and hepatocellular carcinoma; …
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Il-2 Regulation of Il-24 Expression Leads to Growth Suppression of Melanoma Cells
… tumors and subsequent IL-24 mediated tumor growth suppression. Five melanoma cell lines were treated with high dose recombinant hIL-2 at 1000U/ml. Three of the cell lines (A375, WM1341, WM793) showed statistically significant increases in their levels of IL-24 protein when measured by …
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A Stress-Induced TRNA Depletion Response Mediates Codon-Based Translational Repression and Growth Suppression
… in its cognate tyrosine codons, comprising growth and metabolic genes. Consistent with these affected pathways, depletion of tyrosyl tRNAGUA or its downstream targets, EPCAM, SCD, or USP3, repressed growth—revealing a tRNA-dependent growth suppressive pathway for oxidative stress response. A …
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Secreted Factors from CD36+ Fibroblasts Induce Tumor Suppression in Subtypes of Breast Cancer
… autonomous. They are dependent on nutrients and growth-promoting signals provided by stromal cells. In order to instruct the surrounding cells to provide essential growth factors, cancer cells co-opt normal signaling molecules and mechanisms. To inhibit or potentially reverse tumor growth, our …
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Type II Estrogen Binding-Site Agonist: The Synthesis and Biological Evaluation of the Enantiomers of Methyl-Para-Hydroxyphenyllactate (MeHPLA)
… MeHPLA has been observed to suppress the growth of rat uteri in vivo. The high affinity of MeHPLA for the type II EBS suggests that this interaction is responsible for the observed suppression of cell growth. If this interaction is the mode of cell growth suppression, then the chiral …
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Chemical Vapor Deposition of Transition Metal Diborides From Borohydride Precursors
… improved further when an additional flux of a growth suppressor was added during deposition. Super-conformal CrB2 films were deposited by using atomic hydrogen, produced in a remote plasma source, as the suppressor. Growth suppression by atomic nitrogen enabled bottom-up filling of a 19:1 …
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Combination of Dietary Tomato and Broccoli Powders Are Effective Growth Inhibitors of Dunning R3327-H Prostate Adenocarcinomas
Tumor growth suppression was associated with reduced proliferation and increased apoptosis, as quantified by Proliferating Cell Nuclear Antigen (PCNA) immunohistochemistry and the ApoptagRTM assay, respectively. Utilizing real time polymerase chain reactions (RT-PCR) and the SYBR Green assay, mRNA …
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Understanding the Role of Gravity in the Crystallization Suppression of ZBLAN Glass
… processing leads to suppressed crystal growth in ZBLAN glass, which can lead to lower transmission loss in the desired mid-IR range. However, the mechanism governing crystal growth suppression has not been thoroughly investigated. In the present research multiple ZBLAN samples were …
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Differential gene expression in Behcet's disease and differential anti-tumor effects of Tim3 pathway blocking molecules
… increases anti-tumor immunity leading to tumor growth suppression. In this study, I evaluated the tumor suppressive effect of three different molecules blocking Tim3 pathway: Tim3 IgV like domain alone (Tim3V), fusion protein of Tim3V with mouse immunoglobulin CH2CH3 (Tim3VmIg) and its dimer …
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ROLE OF SPARC IN DORMANCY OF PROSTATE CANCER IN THE BONE
… grew rapidly in the bone in vivo, while the growth rates of both cells in culture were similar, suggesting the role of tumor microenvironment in regulation of dormancy and recurrence. Indolent cell was found to secrete a high level of SPARC which significantly stimulated the expression of …
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Action of Allelochemicals on Algal Growth and Photosystem Ii Efficiency
… chemical classes was tested on unicellular algal growth and photosystem II (PSII) efficiency. Chlorella pyrenoidosa Chick and Selenastrum capricornutum Printz were the bioassay species. Fourteen of the 15 allelochemicals investigated resulted in a significant decrease in C. pyrenoidosa growth; 7 …
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Effect of Minimum Suppression and Maximum Release Years on Compression Parallel to Grain Strength and Specific Gravity for Small-sized Yellow-poplar (Liriodendron tulipifera L.) Specimens
… between specific gravity and ring width or growth rate in yellow-poplar (Liriodendron tulipifera L.). Because most mechanical properties of wood are also closely related to specific gravity, it would thus be of interest to learn how minimum suppression and maximum release years' evidence …
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ROLE OF AUTOPHAGY IN RADIOSENSITIZATION OF BREAST TUMOR CELLS
… with autophagy induced by radiation resulted in growth suppression and/or cell killing (primarily by apoptosis). The hormonally active form of vitamin D, 1,25D3, also promoted autophagy in irradiated MCF-7 cells, sensitized the cells to radiation and suppressed the proliferative recovery that …
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Therapeutic Efficacy of P53 Restoration In Mdm2-Overexpressing Tumors
… of wild-type <em>p53</em> has led to tumor growth suppression in various types of tumors lacking p53. Other mechanisms, <em>e.g.</em> upregulation of Mdm2 levels, exist in tumors to inactivate the p53 pathway. Mdm2, an E3 ubiquitin-ligase that targets p53 for proteasomal degradation, is …
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Differential mechanisms by which the aryl hydrocarbon receptor attenuates liver regeneration
… organogenesis and cell cycle control. This growth suppression suggests that AhR modulates critical signaling processes of the regenerative program. In particular, the regeneration process is initiated by both cytokines and matrix enzymes and propagated by the potent mitogenic activity of two …
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Creg1 And Its Enhancement Of P16ink4a-Induced Senescence
<p>Bypassing cellular senescence, an irreversible growth arrest of cells that is activated in normal cells to become immortal is one of the prerequisites for carcinogenesis. Cellular senescence can be triggered by shortening of telomeres and certain cellular stresses. Using spontaneously …
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Drug Delivery to Solid Tumors via Polymeric Nanoparticles
… LMWC and PEG-coated NPs in terms of tumor growth suppression and tumor accumulation. While the exact reason behind the poor in vitro-in vivo correlation remain be confirmed, it is hypothesized to be premature drug release or protein corona formation.
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Synergistic growth inhibition and enhancement of cell death by combination of Melanoma Differentiation Associated gene-7 (MDA-7/IL-24) and cisplatin in ovarian cancer cell lines
… has anti-cancer efficacy by suppressing cell growth and inducing apoptosis in a broad range of tumor cells and does not induce any toxicity in normal cells, thus, making it a potentially effective therapeutic gene for ovarian cancer. The purpose of this study was to evaluate the potential …
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