Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"growth retardation"”.
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The Cellular Basis for Skeletal Muscle Growth Retardation (Undernutrition)
Attempts to explain the basis for permanent growth retardations often focus on the cell number/cell size hypothesis. According to this hypothesis, undernutrition produces irreversible effects if and only if it occurs during the time of rapid DNA accretion. If tissue DNA contents are used to …
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The cellular and molecular mechanisms of glucocorticoid-induced growth retardation
… effects. Long-term use of GCs can result in growth retardation during childhood due to their actions on growth plate chondrocytes, although the exact mechanisms involved are unclear. The work of this thesis has investigated the cellular and molecular mechanisms involved in mediating GC …
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A semiquantitative and qualitative histopathologic assessment of the effect of type II intrauterine growth retardation on the structure of the carotid bodies in fetuses and neonates
… body of foetuses. Clinically, intrauterine growth retardation has been ascribed, amongst other causes, to placental insufficiency that results in chronic hypoxia in the fetus. Intrauterine growth retardation can be divided into two types: - Type I (symmetrical) and type II (asymmetrical). In …
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Cellular subversion: towards a complete repertoire of type-III secretion system effectors in enterohaemorrhagic Escherichia coli O157:H7
… fibres in transfected HeLa cells and caused growth retardation when expressed in yeast. A number of NleG effectors also caused growth retardation and morphological changes when expressed in yeast. Growth retardation caused by the effector NleG8-2 was shown to be dependent on three conserved …
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Die Evaluierung der Dopplersonographie der Aa. uterinae in der 19.-24. Woche zur Vorhersage von Schwangerschaftskomplikationen
… pregnancy induced hypertension, intrauterine growth retardation below 5th centile and preterm delivery before 34 weeks of gestation. Different cutoff values for bilateral RI as 70th, 80th, 90th and 95th centile were examined for the best sensitivity and the lowest false- positive rate at the …
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Untersuchungen zur Rolle genetischer Veränderungen in der chromosomalen Region 11p15 bei der Entstehung des Silver-Russell-Syndroms
… syndrome, associated with pre- and postnatal growth retardation, cranial dysmorphisms, clinodactyly of the fifth finger, skeletal asymmetry and relative macrocephaly. The syndrome usually occurs sporadically, but in some cases a familial accumulation can be observed. 10% of the SRS-Patients …
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Statistical analysis of facial landmark data for optimisation of Fetal Alcohol Syndrome diagnosis
… Diagnosis of FAS depends on evidence of growth retardation, CNS neurodevelopment abnormalities, and a characteristic pattern of facial anomalies, specifically a short palpebral fissure length, smooth philtrum, flat upper lip and flat midface. The unique facial appearance associated with …
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Biochemical studies of targeted and bimodal analogues of the natural anticancer compounds combretastatin A-4 and illudin M
… origin, monitoring their specificity, re-growth retardation and mechanism of apoptosis induction. The proposed drug uptake was analysed using specific inhibitors to disable certain transporters/carriers. Changes in the shapes of cellular and sub-cellular components resulting from drug …
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ANALYSIS OF B LYMPHOCYTES IN MOUSE MODEL LIGASE IV WITH HYPOMORPHIC MUTATION IN VDJ RECOMBINATION ASSOCIATED WITH GROWTH DEFECT
… and may include varying degrees of lymphopenia, growth retardation and microcephaly. The phenotypic effects of the impaired repair of non programmed DNA damage are more diverse and difficult to study. Although such defects in cell survival and proliferation are likely to have an impact on the …
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Early life origins of the insulin resistance syndrome in the aged guinea pig.
In human populations, perturbed growth in early life and ageing have been identified as risk factors for the development of Insulin resistance syndrome (IRS). The consequences of restricted prenatal growth on postnatal function have been investigated using numerous experimental models of …
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The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms
… circulation in hypertension and intrauterine growth retardation (IUGR). 2. The biokinetics of nifedipine and a review of the experiments that have been performed using the drug in human and animal models. 3. The principles of Doppler ultrasound and the literature pertaining to its use in the …
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Untersuchung zu (epi)genetischen Veränderungen auf Chromosom 11p15 und ihre funktionelle Relevanz bei Patienten mit Silver-Russell-Syndrom
… with severe intrauterine and postnatal growth retardation. Typical facial dysmorphisms and further characteristic symptoms can additionally be observed. So far the clinical diagnosis can not be confirmed in all patients with SRS. ~38-63% of SRS patients carry (epi)genetic mutations in …
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Potential roles for Elf3 in fetal alcohol spectrum disorder and development
… is characterized by craniofacial abnormalities, growth retardation, central nervous system defects, learning disabilities and a variety of other minor defects. Even though it affects 2-5% of individuals born every year, very little is known about the mechanisms that cause it. The zebrafish (Danio …
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Availability of zinc from an amino acid chelate in Zn depleted pigs
… body Zn stores, and to cause parakeratosis and growth retardation. Serum Zn concentrations and serum ALP-activities of depleted pigs dramatically decreased (P < .01) during the first 14 d of Zn depletion. At the end of Zn depletion, Zn contents in liver, kidney, pancreas, brain, and small …
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FATTY ACID SYNTHASE MODULATES MAMMARY GLAND LACTATION AND PROSTATE CANCER PROGRESSION IN VIVO
… decreased and nursing pups experienced growth retardation and perished prior to weaning, which was rescued by cross-fostering with a wild-type mother. Chapter III demonstrates the requirement of FASN for the pathological progression of prostate cancer. Prostates from Pten knockout mice …
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Insights into the Functional Link between MtHsp40:MtHsp70 Network and Mitochondrial Homeostasis
… fragmented mitochondria, which resulted in cell-growth retardation. Collectively, we propose that perturbations of mtHsp40:mtHsp70 network might reduce their own activity, which causes OPA1 cleavage and mitochondrial fragmentation depending on DRP1 located in mitochondria, leading to …
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PERINATAL CELLS AS A TREATMENT FOR INFLAMMATORY LUNG DISEASES
… associated with serious adverse events such as growth retardation, and often presents challenges to establish precise doses in patients. Thus, therapeutic regimens provide symptom management in an attempt to slow the progression of the disease however; it is the repeated cycles of inflammation, …
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Perspectives On Ethanol Toxicity In Medaka Embryogenesis And Possible Protection By Asian Ginseng (Panax Ginseng): Histological And Biochemical Analysis
… facial dysmorphogenesis, mental dysfunction, growth retardation, and cardiovascular and limb defects. Due to ethical constraints, human studies of FASD are very limited. Therefore our current understanding of FASD is mainly based on several animal models (vertebrate and invertebrate). The fish …
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The role of the PWWP domain in the DNA methyltransferase 3A targeting to the genome
… the D329A mutation causes dominant postnatal growth retardation in mice. At the molecular level, it results in aberrant progressive acquisition of DNA methylation across domains marked by H3K27me3 and bivalent chromatin in multiple adult tissues. These domains characteristically contain …
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