Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 281 for “"growth factor receptor"”.
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Regulation of hepatocyte growth factor receptor endocytic trafficking
The Hepatocyte Growth Factor Receptor (HGFR/cMet) is a receptor tyrosine kinase that is essential for multiple cell responses, including cell proliferation, survival, motility and branching morphogenesis. Normal HGFR signaling regulates embryonic development, organ regeneration and wound healing, …
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Characterizing and engineering antibodies against the epidermal growth factor receptor
Epidermal growth factor receptor (EGFR) signaling leads to cellular proliferation and migration, and thus EGFR dysregulation can significantly contribute to the survival of tumor cells. Aberrant EGFR signaling due to receptor overexpression, mutation, or autocrine ligand has been observed in a wide …
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Design and applications of antibody mimics against epidermal growth factor receptor
<p>Antibodies have been widely used as reagents, homing devices, diagnostics and as therapeutic agents against different targets in clinic and research. Recently a number of monoclonal antibodies and their drug conjugates have been approved as therapeutic agents. While these molecules have great …
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The Symptom Experience of Patients Receiving Epidermal Growth Factor Receptor Inhibitors
… experience of patients receiving epidermal growth factor receptor inhibitors (EGFRIs) for breast, colon, head and neck, and colon cancer. EGFRIs are targeted therapies used at various points along the treatment continuum for these solid tumors, and may be first, second or third-line agents …
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Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer
… of intricate signaling pathways, such as the Growth Factor Receptor Network (GFRN), which contributes to complex lung tumor heterogeneity allowing for drug resistance development. In this study, gene expression signatures of six GFRN oncogenes overexpressed in human mammary epithelial cells …
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Differential effects of epidermal growth factor receptor inhibitors on glioblastoma multiforme
… overexpression and/or mutation of the epidermal growth factor receptor (EGFR). Also common to this subtype of GBM is the loss of crucial tumor suppressor genes Ink4A/ARF and PTEN, which contribute to the invasive nature and unregulated proliferation that underlie the GBM pathology. The high rate …
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Multiscale Monte Carlo study of epidermal growth factor receptor diffusion and dimerization
The ErbB family of receptors is dysregulated in a number of cancers, and the signaling pathway of this receptor family is a critical target for several anti-cancer drugs. Therefore, a detailed understanding of the mechanisms of receptors activation is critical. However, despite a plethora of …
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Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development
… the main activating ligand of the Epidermal growth factor receptor (Egfr). The experiments presented show that modulation of Egfr activity causes defects in ommatidial rotation and implicate the Raf/MAPK/Pointed cascade as well as the Ras binding protein Canoe as downstream effectors of …
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Insulin-like growth factor receptor activity in cancer biology & therapy responses
The Insulin-like Growth Factor 1 Receptor (IGF-1R) has an essential function in normal cell growth and in cancer progression. However, anti-IGF-1R therapies have mostly been withdrawn from clinical trials owing to a lack of efficacy and predictive biomarkers. IGF-1R activity and signalling in …
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Characterization and informed design of downregulating anti-epidermal growth factor receptor antibodies
… extensive characterization of its role in tumor growth, epidermal growth factor receptor (EGFR) has long been an attractive target for monoclonal antibodies. Intense research has culminated in the approval of two antibody-based drugs against EGFR for cancer treatment, with numerous others in …
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Experimental and computational analysis of epidermal growth factor receptor pathway phosphorylation dynamics
The epidermal growth factor receptor (EGFR, also known as ErbB 1) is a prototypical receptor tyrosine kinase (RTK) that activates multi-kinase phosphorylation cascades to regulate diverse cellular processes, including proliferation, migration and differentiation. ErbB 1 heterooligomerizes with …
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The Ubiquitin Ligase Ube4B Is Required For Efficient Epidermal Growth Factor Receptor Degradation
… back to the plasma membrane. In the case of receptor tyrosine kinases (RTKs), such as epidermal growth factor (EGF) receptor, this important sorting step determines whether a protein returns to the surface to participate in signaling, or whether its signaling properties are inactivated …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
The epidermal growth factor receptor (EGFR) plays a pivotal role in physiological cellular processes, but its aberrant activation is linked to cancer progression. Endocytosis is a critical regulator of EGFR activity. We have previously identified a novel endocytic route of the EGFR, non-clathrin …
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Contribution of Ectodomain Mutations In Epidermal Growth Factor Receptor to Signaling In Glioblastoma Multiforme
… OF ECTODOMAIN MUTATIONS IN EPIDERMAL GROWTH FACTOR RECEPTOR TO SIGNALING IN GLIOBLASTOMA MULTIFORME</strong></p> <p><strong>Publication No._________</strong></p> <p><strong>Marta Rojas, M.S. </strong></p> <p><strong>Supervisory Professor: Oliver Bögler, Ph.D.</strong></p> …
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Epidermal growth factor receptor is an essential component in E-cadherin force-transduction complexes
… proliferation. I also studied how the hetero receptor regulates epithelial proliferation. Results revealed that E-cadherin mutants that uncouple EGFR displayed less effective inhibition of EGFR at confluency when treated with EGF. Notably, WT E-cadherin expressing cells displayed …
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Epidermal Growth Factor Receptor Induces Fyn Expression Via Up-Regulation of P47Phox In Glioblastoma Multiforme
… Since activating mutations in the epidermal growth factor receptor (EGFR) are commonly occurring in GBM, we examined whether EGFR could induce Fyn expression. Here, we found that wild-type EGFR, and to a greater extent hyper-activating EGFR mutants, EGFRΔIII and R108K, induce a substantial …
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Quantitative mass spectrometry analysis of the early signaling dynamics of the epidermal growth factor receptor
… proteins in biology is the Epidermal Growth Factor Receptor (EGFR), which has long been associated with diseases including cancer. Despite development of several EGFR inhibitors, the clinical efficacy of targeting this receptor has been minimal. This shortcoming is attributable …
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The Role of Type I Insulin-Like Growth Factor Receptor Signaling In Breast Cancer Brain Metastasis
… remain largely unknown. The type I insulin-like growth factor receptor (IGF- IR) is known to play a role in the progression of breast cancer and is currently being investigated in the clinical setting for various types of cancer. The present study demonstrates that the IGF-IR signaling axis is …
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