Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1606 for “"growth factor"”.
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Post-Transfer Outcomes in Cultured Bovine Embryos Supplemented with Epidermal Growth Factor, Fibroblast Growth Factor 2, and Insulin-Like Growth Factor 1
… gain for production traits. An uterine paracrine factor cocktail containing epidermal growth factor (EGF), fibroblast growth factor 2 (FGF2), and insulin-like growth factor 1 (IGF1) (collectively termed EFI) was recently identified as a means for improving in vitro derived bovine embryo …
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Characterizing the motogenic response of human keratinocytes to epidermal growth factor and transforming growth factor-alpha
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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Expression Of Growth Factor Inducible Genes
… strategy, and full length cDNA clones for the growth factor inducible genes TIMP, MRP, MEP and calcyclin were isolated, and used to study the temporal and spatial patterns of expression of these genes. The TIMP and MRP cDNAs were used to express the murine proteins in E. coli. The native …
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Connective Tissue Growth Factor in Pancreatitis
… reveal an important role for connective tissue growth factor (CTGF/CCN2) in pancreatic inflammation and fibrosis in a new model of experimental pancreatitis. Progress in studying alcohol pancreatitis has been hampered by the lack of a cost-effective, reproducible and efficient model in mice, …
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Epidermal growth factor and Transforming growth factor α motogenic activities are mediated by Epidermal growth factor receptor : Identification of signalling pathways involved in head and neck cancer
<b> Background</b>: The alteration of Epidermal Growth Factor Receptor (EGFR) plays a major role in the development of Head and Neck cancer. However, the only FDA approved EGFR target for this neoplasm is the drug Cetuximab. Cetuximab can only be used where there is an over-expression of EGFR. …
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Transforming Growth Factor Beta1 und Platelet Derived Growth Factor im Serum und in bronchoalveolärer Lavage bei idioapthischen Lungenfibrosen
… Spiegel der profibrotische Zytokine Transformig Growth Factor ß1 (TGF ß1) und Platelet Derived Growth Factor AB (PDGF-AB) im Serum und in der Bronchoalveolären Lavagenflüssigkeit (BALF) von 87 Patienten mit ILD mittels ELISAs. Dann suchten wir nach Korrelationen zu klinischen Parametern. Bei der …
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
… presence of several members of the fibroblast growth factor signaling axis. In particular acidic fibroblast growth factor (<em>FGF1</em>) has been demonstrated to be one of the driving genes in mediating the observed prognostic effect of the amplicon in ovarian cancer patients. This study seeks …
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Anti-vascular endothelial growth factor in ophthalmology
Vascular endothelial growth factor, secreted by the neurovascular retina, acts as an essential regulator in vasculogenesis, angiogenesis, and increased vascular permeability, which plays a critical role in the pathophysiology of ischemia-related retinal illnesses, inducing aberrant …
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Metabolic Regulation by Fibroblast Growth Factor 21
Fibroblast growth factor 21 (FGF21) is a secreted hormone that can beneficially regulate glucose and lipid homeostasis. Through a reverse endocrinology approach, we uncovered that FGF21 expression is transcriptionally regulated by the peroxisome proliferator activated-receptor alpha (PPARa) in …
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Vascular Endothelial Growth Factor In Cortical Development
… each other and intimately linked.</p> <p>Many growth factors and transcription factors have roles in both angiogenesis and neurogenesis. Members of both the Notch and Inhibitor of DNA binding (Id) family of proteins have been shown to guide differentiation in neural stem cells, as well as to …
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CONNECTIVE TISSUE GROWTH FACTOR IS REQUIRED FOR CHONDROGENESIS
Connective tissue growth factor (CTGF, CCN2) is expressed by mesenchymal cells during development. Mice genetically deficient in CCN2 display severe bone defects and die immediately after birth. The molecular basis of this defect is not known. We've used in vitro models of chondrogenesis to show …
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Regulation of hepatocyte growth factor receptor endocytic trafficking
The Hepatocyte Growth Factor Receptor (HGFR/cMet) is a receptor tyrosine kinase that is essential for multiple cell responses, including cell proliferation, survival, motility and branching morphogenesis. Normal HGFR signaling regulates embryonic development, organ regeneration and wound healing, …
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hepatocyte growth factor inhibits glial scar formation and
Formation of glial scars physically impedes growth of regenerating axons following CNS injuries such as spinal cord trauma. Glial scars also produce various species of chondroitin sulfate proteoglycans (CSPGs) that act as a potent inhibitor of axon growth. Thus, inhibition of glial scar formation …
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Glycosaminoglycan-protein interactions : the fibroblast growth factor paradigm
… such as anticoagulation, angiogenesis and growth factor activation. The specificity involved in the HSGAG-protein interactions stems from the structural heterogeneity of HSGAGs, which are highly acidic biopolymers associated on the cell surface and in the extracellular matrix. It is …
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Identification of novel components in fibroblast growth factor signalling
Fibroblast growth factor receptors play many roles in development, cell proliferation and differentiation. They possess intrinsic tyrosine kinase activity which enables activation of other signalling proteins, formation of multiprotein signalling complexes and activation of downstream cascades. The …
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