Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"growth cones"”.
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Local Protein Turnover As a Regulatory Mechanism of Growth and Collapse of Neuronal Growth Cones
Der axonale Wachstumskegel reagiert außergewöhnlich empfindlich auf chemische und mechanische Umgebungseinflüsse, was lokale, autonome Reaktionen hinsichtlich der Wachstumskegel-Morphologie ermöglicht. Abhängig vom jeweiligen Stimulus kann Wachstum auf der einen Seite, oder Kollaps des …
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Axon Guidance Autonomy and Tensional Requirement for Synaptic Function: Is Learning a Forced Response
… neurons extend multiple processes whose growth cones exhibit different responses to their environment. In culture, detached growth cones display guidance autonomy, contain mRNA for cytoskeletal and other axonal components, and are capable of synthesizing protein locally. However, the …
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Analysis of Growth Cone Signaling During Axon Development in Drosophila Melanogaster
In addition, I demonstrated that growth cones expressing constitutively active Cdc42 that displayed guidance defects exhibited little change in their filopodial activity when compared to wild type, whereas others without guidance defects exhibited a significant increase. Moreover, the Y40C …
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The role of semaphorin 3A signaling underlying learning and memory formation in the postnatal mouse brain
… system through their chemorepulsive action at growth cones. Growth cones are actin-rich structures found at the tips of neurites that eventually form synaptic connections, and semaphorins were shown to trigger collapse and retraction of these growth cones, altering the ability to form synaptic …
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Substrate stiffness tunes the neuronal response to the chemical guidance cue semaphorin3A
… by a sensorimotor apparatus called the neuronal growth cone, located at the tip of the growing axon. Growth cones rely on signals present in their environment to navigate. Previous research has primarily examined how growth cones sense and respond to chemical guidance cues. However, the nervous …
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Quantitative analysis of axon elongation : a novel application of stochastic modeling techniques to long-term, high-resolution time-lapse microscopy of cortical axons
… developed a system for in vitro imaging of axon growth cones with time-lapse fluorescence microscopy. Image tiles are automatically captured and assembled into a mosaic image of a square millimeter region. GFP-expressing mouse cortical neurons can be imaged once every few minutes for up to weeks …
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Elucidation of the Retinoid Signalling Pathway Involved in Axon Guidance in Lymnaea stagnalis and Xenopus laevis
… has been shown to act as a guidance molecule for growth cones of regenerating motorneurons of the pond snail, Lymnaea stagnalis. Our lab has recently shown that RA can induce this morphological response independent of nuclear transcription, however, the role of the retinoid receptors in RA-induced …
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RhoA and Rac1 prenylation: Effects on serine/threonine signaling for actin polymerization
… decrease the actin filament content in neuronal growth cones by altering the location of actin regulating molecules. In particular, it was hypothesized that non-geranylgeranylatable RhoA or Rac1 would decrease the activity of actin filament promoters (i.e association of WAVE with the ARP2/3 …
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Myosin 10 is Required for Spinal Motor Axon Growth and Guidance in Zebrafish Embryos
… grow towards their specific target organs at growth cones, by sensing the environment for molecular cues which reorganizes their cytoskeleton to allow for their growth. Growth cones are actin rich suggesting that actin binding molecules play a vital role in axon guidance. Myosins are a class …
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Von der Form zur Richtung
Growth cones, the terminal structures of elongating neurites are important for development and regeneration. The second messenger cAMP regulates both processes. cAMP is also known to induce growth cone turning. By using time-lapse microscopy and release of cAMP from biological inactive caged …
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Mechanisms of Synapse Formation and Synaptic Plasticity
… course of synaptogenesis, I developed a novel “growth ball” model to study synapse at the level of isolated growth cones. Specifically, I found that functional synapses can reform in isolated growth cones within minutes of contact with their synaptic partner. However, in the absence of the cell …
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Growth Cone Pathfinding and Neuromuscular Synaptogenesis in Drosophila Midline Mutants
… how abnormal midline decisions affect subsequent growth cone pathfinding. Results showed that despite abnormal decisions at the midline, subsequent pathways and synaptic targeting in all cases were the perfect mirror-images of those seen in wildtype. This suggests that a growth cones' particular …
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Filopodial Dynamics and Synapse Specification in the Drosophila Visual System
… subcellular substrate of connectivity: axonal growth cones. To gain access to the details of their dynamic behavior during development, I developed an imaging technique which allows the monitoring of intact, developing fly brains over long periods in high temporal and spatial resolution. Using …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
… to assess the presence of macrophages, Growth Associated Protein (GAP-43), and growth cones as detected through F-actin. The results show that GAP-43, which naturally increases expression during nerve regenerations is precociously activated days earlier than normal when CXB-NE is …
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Retinoic Acid and the Underlying Cellular Mechanisms involved in Neurite Outgrowth and Growth Cone Turning during Regeneration
… as well as tropic effects to guide neurite outgrowth. Cultured neurons of the Lymnaea central nervous system (CNS) have previously been used to investigate the role of RA in neurite outgrowth and growth cone guidance. Recently however, a novel phenomenon has been identified, in which neurite …
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Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
… envelope glycoproteins can act on advancing growth cones in the developing nervous system, leading to derangement of neuronal connectivity. We tested this hypothesis by applying an oligopeptide derived from the envelope glycoprotein of FeLV to the growth cones of cultured neurons and …
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Cellular Interactions During Motor Nerve Regeneration
… axons with factors that stimulate outgrowth, and an adhesive substrate that axons preferentially extend along during regeneration, yet their role in guiding regenerating axons onto their original trajectory is less clear. We show in mutants lacking Schwann cells that axonal growth …
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Axon guidance in the zebrafish visual system: Analysis of Esrom Mutant
… to regulate phosphorylated tuberin within the growth cones. These data suggest that esrom might act as a molecular switch to integrate signal transduction events in axons.
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Building a Consistent Neuronetwork: Defining Molecular Cues Involved in the Synaptic Target Recognition of Drosophila Melanogaster
… disparate, can be summated by individual growth cones based upon the relative amounts of either cue present to arrive at a net synaptic decision. Both of these molecules act at the ultrastructural level to affect the presence of tight membrane-membrane apposition (focal adhesion) between …
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