Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 77 for “"grey matter"”.
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Grey matter morphological changes in late life using magnetic resonance imaging technique
This PhD thesis examines grey matter (GM) morphological changes in an elderly non‐demented population, and is divided into three broad topic areas. While a few structural MRI studies have examined the relationship between cognitive function and brain morphology using regions of interest …
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The Effect of C-Section Birth on Attention Task Performance and Cortical Grey Matter Integrity
… potential effects of C-section birth on cortical grey-matter integrity. Findings suggest that there is an effect of C-section birth on top-down attention but were not significant for other hypotheses in the experiment and MRI analysis.
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Mechanical characterisation of rodent spinal cord tissue in health, trauma and disease
… affected the measured stiffness of healthy grey and white matter in the rat. I found that even though increasing these parameters generally led to an increase in the measured stiffness, grey and white matter were affected to a different degree. This led to a decrease in the ratio of grey to …
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Morphological alterations in frontotemporal dementia:
… measuring morphological alterations in the white matter by diffusion tensor imaging (DTI)- MRI, compared with the more commonly used assessment of grey matter thickness and volume. DTI-MRI was better at separating FTD cases from controls than grey matter parameters, and may thus be a promising …
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Genetic influence on brain volumes in psychosis.
… the first analysis I compared grey, white and whole brain volumes between patients and healthy controls (Chapter 5). Patients with schizophrenia spectrum psychoses showed smaller grey matter and larger white matter volume, and smaller whole brain volume than healthy controls. …
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Behavioural, genetic and epigenetic determinants of white matter pathology in a new mouse model of chronic cerebral hypoperfusion
Recent clinical studies suggest that white matter pathology rather than grey matter abnormality is the major neurobiological substrate of age- related cognitive decline during “healthy” aging. According to this hypothesis, cerebrovascular (e.g. chronic cerebral hypoperfusion) and molecular (e.g. …
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On the neurobiology of apathy and depression in cerebral small vessel disease
… in SVD. We show that apathy is related to focal grey matter damage and distributed white matter microstructural change. These microstructural changes underlie large-scale white matter network disruption, which is related to apathy, but not depression. We then show that depression, as a construct, …
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FMRI guided DTI at the grey-white matter interface : with application to a connectivity analysis of the default mode network in Urbach-Wiethe disease
… cerebral cortex is composed of a thin layer of Grey Matter (GM), functionally subdivided into discrete regions which are connected in a large scale network via White Matter (WM) tracts. With fMRI (Functional Magnetic Resonance Imaging) it is possible to identify cortical regions involved in …
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Development of a voxel-based meta-analytic method for neuroimaging studies
… such as the separate analyses of positive (e.g. grey matter volume increases) and negative (e.g. grey matter volume reductions) findings, not accounting for the effect size, not taking sample size, intra-study variance or between-study heterogeneity into account, and not allowing combination of …
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Understanding mechanisms related to psychosis in Motor Neurone Disease
… Using a Freesurfer regions-of-interest approach, grey matter volume correlated inversely with CBI-R psychosis index in the caudate, amygdala, cingulate and hippocampus. Using tract-based spatial statistics, increased mean diffusivity (MD) of diffusion weighted imaging correlated with the CBI-R …
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Lexical-semantic parameters as robust endophenotypes of abnormal cognitive decline in ageing
… competency in aMCI carriers as an endophenotype, grey matter volume loss in aMCI ε4 carriers/non-carriers and in controls was compared and the residual volume correlated with allele burden and with age of acquisition values for words produced in a category fluency task. Direct group comparisons …
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Investigating the Use of [18-F] tau-PET Imaging as a Biomarker of tau Pathology in Retired Athletes at Risk of Neurodegeneration
… We found an association between higher cortical grey matter tau burden as seen with flortaucipir and the APOE4 allele in former athletes. APOE4 allele may be a risk factor for tau accumulation in former contact sports athletes at high risk of neurodegeneration. Next, we investigated the use of …
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Amygdala and Prefrontal Cortex Macrostructure and White Matter Microstructure Development in Typical and Atypical Children and Adolescents
… Brain development is region-dependent, with deep grey matter structures such as the amygdala plateauing developmentally before the PFC. The developmental mismatch hypothesis proposes that this difference, or mismatch, in maturational timing underlies elevated adolescent sensation-seeking …
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Neural correlates of deficits in affect regulation in methamphetamine abusers with and without a history of psychosis
… tensor imaging were employed to determine grey matter and white matter structural abnormalities, respectively, and to correlate findings with the presence/absence of affect dysregulation and psychotic symptoms. Both methamphetamine-dependent groups showed deficits in emotion regulation …
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Blushing and gaze avoidance in social anxiety disorder : a structural neuroanatomical investigation
… with brain volumes, controlling for total grey matter volume, age and level of education. Results: Anxiety, blushing propensity and gaze fear and avoidance symptoms were all significantly higher in SAD patients (p<0.001). Brainstem volumes were increased for higher blushing scores a …
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BRAIN STRUCTURE AND FUNCTION ASSOCIATED WITH EMOTION DYSREGULATION IN TYPICAL DEVELOPMENT AND NEURODEVELOPMENTAL DISORDERS
… employed to explore the association of ED with grey matter volume (GMV) and resting state functional connectivity (FC) in TD (study 1), and in boys with ADHD, ASD, and ADHD comorbid ASD (study 2). In study 1, gender moderated the association of ED with both GMV and FC in insula and inferior …
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The role of retinoids in the regeneration of the axolotl spinal cord
… the pia and dura mater meningeal layers, in gray matter neurons (including their axonal processes), and the ependymal cell radial processes that produce the glia limitans, 2) CRABP 2 is expressed in the arachnoid and/or dura mater meningeal layers surrounding the spinal cord, and 3) RALDH 2 is …
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Subacute measles encephalitis: The neurological sequelae of the measles outbreak in South Africa
… (MRI) Brain demonstrated superficial and deep grey matter abnormalities in the majority of patients with contiguous cortical spread over weeks documented in one patient. Electroencephalograms (EEGs) showed periodic epileptiform discharges in seven patients. Diagnosis was confirmed by brain …
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Neural Mechanisms Supporting Default Mode Network Regulation of Pain Sensitivity
… employed to determine the relationship between grey matter density across the whole brain and inter-individual differences in pain sensitivity. Additionally, psychophysiological interaction (PPI) analyses were employed to determine the FC of DMN regions during pain and how functional connections …
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