Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"gray platelet syndrome"”.
-
The role of Nbeal2 in the homeostasis and retention of granules in haematopoietic cells
Gray platelet syndrome (GPS) is a rare disorder primarily characterised by the absence of α-granules in platelets. Typical clinical features of GPS include macrothrombocytopenia, abnormal or excessive bleeding, splenomegaly, and bone marrow fibrosis. GPS is caused by biallelic mutations in the …
-
Genetic and functional studies in inherited platelet disorders
Platelets are anucleate blood cells containing secretory granules, which play a critical role in haemostasis, atherogenesis, thrombosis, and wound healing. Platelet number, volume, and function are genetically regulated, and genome wide association studies have identified more than 1000 loci …