Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"granzyme B"”.
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Einfluß körperlicher Ausdauerbelastung auf Perforin und Granzyme-B exprimierende Lymphozytenpopulationen
In dieser Studie wurden die Auswirkungen von Ausdauertraining auf submaximalen Belastungsstufen auf Lymphozyten des peripheren Blutes untersucht. In zahlreichen Studien konnte nachgewiesen werden, daß die durch Belastung induzierten Veränderungen immunologischer Parameter eng mit hormonellen und …
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Investigation of the role of HSP70 in the uptake of Granzyme B by Malaria parasite-infected erythrocytes
… bound Hsp70 is thought to recruit NK cells and Granzyme B (GrB) via its 14 amino acid sequence, TKDNNLLGRFELSG, known as the TKD motif. Both PfHsp70-x and human Hsp70 (hHsp70) contain the TKD motif. Thus, this study sought to investigate the role of Hsp70 in facilitating the selective targeting …
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Granzyme B- und Perforin-positive Lymphozyten in der bronchoalveolären Lavage und dem perpheren Blut bei Patienten mit Asthma bronchiale
… bestimmt, dann wurde intrazellulär Granzyme B bzw. Perforin mit Antikörper markiert. Gemessen wurde mittels FACS. Weiterhin wurden die Veränderungen nach Kultivierung oder Stimulation mit PMA und Ca-Ionophore bzw mit anti-CD3 bestimmt.
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Dissociated expression of granzyme B and IFN-gamma by T lymphocytes in HIV-1 infected individuals and its implications for Tc1 effector diversity
… two effector function of CD8+ cells are linked. Granzyme B (GzB) is stored in cytolytic granules of CD8+ cells and its secretion is induced by antigen recognition of these cells. Following entry into the cytosol GzB induces apoptosis in the target cells. It was measured whether GzB release by …
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The Role of Serine Protease Inhibitors in Regulating Hepatotoxicity During Viral Infection
… cells by two major pathways, the perforin/granzyme pathway and the Fas and/or TNF death receptor pathways. In contrast to other target cells, virally infected hepatocytes are resistant to killing by perforin and granzyme-dependent cytotoxic effector pathways. This results in a more …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… of Fas on splenic CD4+ lymphocytes and granzyme B in hepatic CD8+ lymphocytes, and decreased the expression of CD40 on APCs. Surprisingly, absence of CD40L did not result in decreased pathology as indicated by similar serum TNF-alpha concentrations, organ bacterial burdens, and liver …
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Crosstalk between natural killer cells and cancer associated fibroblasts in the tumour microenvironment
… functions such as tumour killing capacity and granzyme B secretion. *In vivo*, targeting this crosstalk by blocking PGE2 receptors EP2 and EP4 with antagonists reduced tumour growth and restored NK and T cell derived granzyme B. This work revealed unknown and contrasting roles for CAF …
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Heat shock protein 27 inhibition of the caspase cascade in human breast cancer cells
… c, the caspase cascade was reactivated. Granzyme B activated caspase 3 even in the presence of HSP 27. This suggests the conclusion that HSP 27 is a novel inhibitor of apoptosis by binding to cytochrome c.
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Generating memory cytotoxic T lymphocytes through repetitive peptide boosting
… by decreased interferon-gamma but increased granzyme B production. These results are independent of the specific adjuvant applied and are observed in both transgenic and endogenous models. Overall, our findings have important implications for future vaccine development, as they suggest that …
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Comparing high-throughput methods to measure antibody dependent cellular cytotoxicity during HIV infection
… cytotoxicity. The individual with the highest granzyme B and caspase activity against K562 cells was chosen as the universal NK cell donor for this study.
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Influenza Viral Protein Interaction Detecting Methods Development and A.M1-host Interplay Network Investigation
… aldosterone signaling in epithelia cells and granzyme B signaling. And mechanism of viral exit from host cells, DNA double-stain break repair by non-homologous end joining and granzyme B signaling are top three abundant pathways been identified.</p>
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Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine
… cells and expression of effector molecules like granzyme B and perforin in vivo. Simultaneously, mSOT201 promoted the establishment of CD44hi CD122hi CD8+ long-lived memory T cell subset that mounted rapid recall responses upon antigen restimulation ex vivo. A single dose of mSOT201 completely …
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The potential of exosome-based gene therapy to eradicate glioblastoma cells
… combination gene therapy encoding the cytotoxins Granzyme B and Diphtheria toxin fragment A.
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Selective allodepletion to improve anti-viral and anti-leukaemic responses after haploidentical transplantation
… be redirected to recognize and secrete IFN-γ and granzyme B in response to CD19 cell lines and primary ALL blasts through lentiviral transfer of a chimeric αCD19ζ TCR. This strategy may facilitate immunotherapy with larger doses of allodepleted T-cells after haplo-SCT, enhancing graft versus …
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Elucidation of Mechanisms of Host Immunity against Orientia tsutsugamushi in a Newly Developed Murine Model
… than those in WT mice. Interferon-γ (IFN-γ) and granzyme B mRNA levels in the liver of CD8-/- and MHC I-/- mice were significantly greater than in WT mice. In addition, more severe histopathologic lesions were observed in CD8-/- mice. Finally, adoptive transfer confirmed a major role of activated …
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Effects of TGF-β Inhibitor on Chemoresistance in Ovarian Cancer Models
… (EMT) and immune evasion via suppression of Granzyme B (Gzmb) and Perforin (Prf1) expression in cytotoxic T cells. We hypothesized that treatments of HGSC models with TGFβR1 inhibitor galunisertib (LY) would increase sensitivity to chemotherapy drugs such as doxorubicin (Dox). Using several …
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Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression
… anti-tumor immunity, including the expression of granzyme B (GzmB) and other cytolytic effectors in CD8+ T cells. To address this challenge, we established a simplified co-culture model of the HGSC TME to test immunotherapies and combination strategies capable of overcoming a high-TGF-β …
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Congenital Chagas Murine Model Development and Nanovaccine Efficacy Against Maternal-fetal Trypanosoma cruzi Pathogenesis
… production of interferon gamma, perforin and granzyme B that exhibit cytolytic activities against the infected cells. Further, nanovaccine immunized pregnant mice exhibited effective control of the parasite burden in maternal tissues and inflammatory infiltrate, necrosis, and fibrosis in …
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Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… local and systemicimmune activation, improving Granzyme B+ cell infiltration, boosting collagen deposition, reducing immunosuppressive cytokine signaling, and promoting anabscopal response in distant, untreated tumors. In accordance with these results, RFA may help the immune system to overcome …
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