Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"granzyme A"”.
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Biochemical Characterization of IpaH E3 Ubiquitin Ligase Effector Proteins and Their Host Substrates
… activity of Natural Killer cells by suppressing Granzyme-A mediated activation of GSDMB. In contrast to the canonical function of most Gasdermin-family members, GSDMB does not inhibit Shigella by lysing infected cells. Rather, GSDMB exhibits direct microbiocidal activity through recognition of …
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Reprogramming the immune environment in breast cancer via dendritic cells.
… These CD8+ T cells, which produce higher IFN-γ, Granzyme A and Granzyme B, accumulate in the tumors leading to enhanced tumor necrosis in vivo. DC reprogramming by β-glucan is dependent upon dectin-1 engagement. The ligand of TLR7/8 (CL075) and TLR3 (polyI:C) show the same effect in Th2 response …
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The TREX1 3' Exonuclease and Autoimmune Disease: Structural and Biochemical Analysis of Disease Mutants Involved in Autoimmune Dysfunction
… degradation of nicked genomic DNA during the granzyme A cell death pathway, disposing of single-stranded DNA aberrant replication intermediates, and degrading DNA derived from endogenous retroelements. Four conserved acidic residues (D18, E20, D130, D200) coordinate two divalent cations within …
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Untersuchungen zur Rolle von zytotoxischen Molekülen bei der Immunabwehr gegen Retroviren
… weisen auf neue molekulare Mechanismen von Granzymen bei der Virusabwehr hin. In Gegensatz zur Abwehr des pathogenen FV Komplex benutzten CD8+ T-Zellen nicht den Exozytoseweg zur Abwehr von apathogenen Retroviren. Eine Infektion von Mäusen mit dem nicht-pathogenen F-MuLV induzierte keine …
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Improvement of the Capripoxvirus, lumpy skin disease virus for use as a vaccine vector
… in the unique expression of 36 genes, including granzyme A and Poly (ADP-ribose) polymerase (Parp 9). Herbivac upregulated genes associated with pathogen pattern recognition, interferon response, immune response and cell death. More Gene ontology (GO) processes were enriched after Herbivac …
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The Role and Immunogenicity of CBFA2T3-GLIS2 in Pediatric Acute Megakaryoblastic Leukemia
… responses correlating with an increase in granzyme A production and a decrease in TCR diversity; consistent with a potential clonal expansion of leukemia-specific effector CD8+ T cells. Single TCR expressing stable cell lines will be generated for the top expanded clones and used to assess …