Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"granzyme"”.
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Einfluß körperlicher Ausdauerbelastung auf Perforin und Granzyme-B exprimierende Lymphozytenpopulationen
In dieser Studie wurden die Auswirkungen von Ausdauertraining auf submaximalen Belastungsstufen auf Lymphozyten des peripheren Blutes untersucht. In zahlreichen Studien konnte nachgewiesen werden, daß die durch Belastung induzierten Veränderungen immunologischer Parameter eng mit hormonellen und …
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Investigation of the role of HSP70 in the uptake of Granzyme B by Malaria parasite-infected erythrocytes
… bound Hsp70 is thought to recruit NK cells and Granzyme B (GrB) via its 14 amino acid sequence, TKDNNLLGRFELSG, known as the TKD motif. Both PfHsp70-x and human Hsp70 (hHsp70) contain the TKD motif. Thus, this study sought to investigate the role of Hsp70 in facilitating the selective targeting …
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Expression of perforin and granzyme variants in adult rat testes after ethylene dimethane sulfonate (EDS)-induced testosterone depletion
… we investigated the relationship between granzyme and perforin, and germ cell apoptosis. To confirm effects of testosterone depletion, EDS-treated rats were compared with testosterone-replaced and testosterone-supplemented rats. At 5 and 7 days post-EDS treatment, rats were euthanized for …
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Granzyme B- und Perforin-positive Lymphozyten in der bronchoalveolären Lavage und dem perpheren Blut bei Patienten mit Asthma bronchiale
… bestimmt, dann wurde intrazellulär Granzyme B bzw. Perforin mit Antikörper markiert. Gemessen wurde mittels FACS. Weiterhin wurden die Veränderungen nach Kultivierung oder Stimulation mit PMA und Ca-Ionophore bzw mit anti-CD3 bestimmt.
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Dissociated expression of granzyme B and IFN-gamma by T lymphocytes in HIV-1 infected individuals and its implications for Tc1 effector diversity
… two effector function of CD8+ cells are linked. Granzyme B (GzB) is stored in cytolytic granules of CD8+ cells and its secretion is induced by antigen recognition of these cells. Following entry into the cytosol GzB induces apoptosis in the target cells. It was measured whether GzB release by …
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The Role of Serine Protease Inhibitors in Regulating Hepatotoxicity During Viral Infection
… cells by two major pathways, the perforin/granzyme pathway and the Fas and/or TNF death receptor pathways. In contrast to other target cells, virally infected hepatocytes are resistant to killing by perforin and granzyme-dependent cytotoxic effector pathways. This results in a more …
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Die Bedeutung von Granzym A, B, K und Perforin bei gesunden Personen und in der Pathogenese chronischer Lungenerkrankungen
Granzyme sind Serinproteasen, die in Vesikeln zytotoxischer Lymphozyten gespeichert werden. Durch ihre Fähigkeit zum Schneiden intra- wie extrazellulärer Substrate und zur Induktion von Apoptose sind sie gemeinsam mit Perforin bei der Abwehr von Infektionen, Tumorzellen, transplantiertem …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… of Fas on splenic CD4+ lymphocytes and granzyme B in hepatic CD8+ lymphocytes, and decreased the expression of CD40 on APCs. Surprisingly, absence of CD40L did not result in decreased pathology as indicated by similar serum TNF-alpha concentrations, organ bacterial burdens, and liver …
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Crosstalk between natural killer cells and cancer associated fibroblasts in the tumour microenvironment
… functions such as tumour killing capacity and granzyme B secretion. *In vivo*, targeting this crosstalk by blocking PGE2 receptors EP2 and EP4 with antagonists reduced tumour growth and restored NK and T cell derived granzyme B. This work revealed unknown and contrasting roles for CAF …
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Heat shock protein 27 inhibition of the caspase cascade in human breast cancer cells
… c, the caspase cascade was reactivated. Granzyme B activated caspase 3 even in the presence of HSP 27. This suggests the conclusion that HSP 27 is a novel inhibitor of apoptosis by binding to cytochrome c.
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Generating memory cytotoxic T lymphocytes through repetitive peptide boosting
… by decreased interferon-gamma but increased granzyme B production. These results are independent of the specific adjuvant applied and are observed in both transgenic and endogenous models. Overall, our findings have important implications for future vaccine development, as they suggest that …
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Comparing high-throughput methods to measure antibody dependent cellular cytotoxicity during HIV infection
… cytotoxicity. The individual with the highest granzyme B and caspase activity against K562 cells was chosen as the universal NK cell donor for this study.
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Influenza Viral Protein Interaction Detecting Methods Development and A.M1-host Interplay Network Investigation
… aldosterone signaling in epithelia cells and granzyme B signaling. And mechanism of viral exit from host cells, DNA double-stain break repair by non-homologous end joining and granzyme B signaling are top three abundant pathways been identified.</p>
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Reprogramming the immune environment in breast cancer via dendritic cells.
… These CD8+ T cells, which produce higher IFN-γ, Granzyme A and Granzyme B, accumulate in the tumors leading to enhanced tumor necrosis in vivo. DC reprogramming by β-glucan is dependent upon dectin-1 engagement. The ligand of TLR7/8 (CL075) and TLR3 (polyI:C) show the same effect in Th2 response …
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Cholesterol-Dependent Cytolysins and Perforin: Similar Pore-Forming Mechanisms in Pathogenic Attack and Human Immune Defense
… involved in the apoptotic pathway facilitating Granzyme release. In the literature, two possible configurations of CDCs and Perforin pores are proposed: ring and arc structures that could have different implications on the biological mechanism of action of these pore-forming proteins. By …
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Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine
… cells and expression of effector molecules like granzyme B and perforin in vivo. Simultaneously, mSOT201 promoted the establishment of CD44hi CD122hi CD8+ long-lived memory T cell subset that mounted rapid recall responses upon antigen restimulation ex vivo. A single dose of mSOT201 completely …
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How TCR signal strength controls CTL polarisation for target killing
… of the cytolytic components, perforin and granzyme, from modified lysosomes to kill the target cell. My PhD has utilised amino acid substitutions in the target peptide to alter its signal strength and shown this alters the subsequent killing efficiency of a target population. I developed …
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The potential of exosome-based gene therapy to eradicate glioblastoma cells
… combination gene therapy encoding the cytotoxins Granzyme B and Diphtheria toxin fragment A.
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Effects of TGF-β Inhibitor on Chemoresistance in Ovarian Cancer Models
… (EMT) and immune evasion via suppression of Granzyme B (Gzmb) and Perforin (Prf1) expression in cytotoxic T cells. We hypothesized that treatments of HGSC models with TGFβR1 inhibitor galunisertib (LY) would increase sensitivity to chemotherapy drugs such as doxorubicin (Dox). Using several …
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