Global ETD Search

The role of the cytolytic mediators, granulysin and perforin, in tuberculosis

Semple, Patricia LynnDivision of Clinical Immunology2008

… granule-dependent killing of infected cells. Granulysin, an antimicrobial protein, and perforin, a pore-forming molecule, have been found to co-localise in the granules of these two cell types. Granulysin has been shown to be directly cytotoxic to extracellular Mycobacterium tuberculosis …

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Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovis DeltaRD1

Charles Fernando Capinos SchererThe University of Texas Medical Branch2008

… bovine homologues of the antimicrobial protein granulysin (Bo-lysin) and perforin by our group could be used as potential biomarkers for TB vaccination efficacy. In the present study we examined the kinetics of granulysin, perforin, IFNgamma and Fas-L responses to Mycobacterium bovis purified …

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Antigen- und sauerstoffabhängige Steigerung der Expression des antimikrobiellen Peptids Granulysin durch den Hypoxie-induzierten Faktor-1alpha (HIF-1alpha) in humanen T-Lymphozyten

Schercher, EsraUniversität Ulm

ulm-diss Repository record for Antigen- und sauerstoffabhängige Steigerung der Expression des antimikrobiellen Peptids Granulysin durch den Hypoxie-induzierten Faktor-1alpha (HIF-1alpha) in humanen T-Lymphozyten (opens in a new tab)

Isolation und Charakterisierung extrazellulärer Vesikel aus humanen CD8+- und γδ-T-Lymphozyten

Griesel, LisaChristian-Albrechts-Universität zu Kiel

… ebenso das zytotoxische Effektorprotein Granulysin. Um die Proteinzusammensetzung der EV zu untersuchen erfolgte eine vergleichende Proteomanalyse mittels Tandem-Massenspektrometrie. Dabei konnten über 900 Proteine identifiziert und 686 Proteine quantifiziert werden. Die Daten der …

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Using Genetic and Pathogeneses Studies to Develop Antiviral and BVDV Vaccine Targets

Darweesh, Mahmoud2017

… and functional markers, CD2, NKp46, CD25, and granulysin were affected differently by BVDV 1373 than BVDV 28508.5. Both strains reduced NK cell cytotoxicity function. BVDV RNA and E2 protein were detected inside NK cells after exposure to BVDV 1373 with no indication of production of infectious …

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Immune-driven positive and balancing selection in human populations

Kaewert, SarahUniversity of Cambridge2019

… a gene that produces the antimicrobial protein granulysin, in the West Siberian and Island Southeast Asian populations. Another is PGLYRP4, which is a top gene in seven populations and is involved in recognition and defense against Gram-negative and -positive bacteria. In conclusion, as a …

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